Ddx6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ddx6
DEAD-box helicase 6
MGI:104976

29 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ddx6^em1(IMPC)Mbp/Ddx6⁺ C57BL/6N-Ddx6^em1(IMPC)Mbp/Ucd	abnormal kidney morphology	J:211773
	abnormal liver morphology	J:211773
	abnormal neural tube morphology	J:211773
	abnormal skin morphology	J:211773
	decreased startle reflex	J:211773
	increased circulating total protein level	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased mean corpuscular volume	J:211773
Ddx6^em1(IMPC)Mbp/Ddx6^em1(IMPC)Mbp C57BL/6N-Ddx6^em1(IMPC)Mbp/Ucd	abnormal embryo turning	J:211773
	embryonic lethality prior to organogenesis	J:211773
	prenatal lethality prior to heart atrial septation	J:211773
	preweaning lethality, complete penetrance	J:211773
Ddx6^em1.1Ysa/Ddx6^em1.1Ysa Tg(Ddx4-cre)1Dcas/0 involves: 129S4/SvJaeSor * C57BL/6NCrlj * CBA/JNCrlj * FVB	abnormal ovarian follicle morphology	J:282136
	abnormal ovary morphology	J:282136
	abnormal primordial ovarian follicle morphology	J:282136
	absent oocytes	J:282136
	decreased primary ovarian follicle number	J:282136
	decreased primordial ovarian follicle number	J:282136
	decreased secondary ovarian follicle number	J:282136
	decreased tertiary ovarian follicle number	J:282136
	female infertility	J:282136
Ddx6^em1.2Ysa/Ddx6^em1.2Ysa involves: C57BL/6NCrlj * CBA/JNCrlj	abnormal embryo development	J:329565
	abnormal primitive streak formation	J:329565
	abnormal rostral-caudal axis patterning	J:329565
	caudal body truncation	J:329565
	decreased embryo size	J:329565
	embryonic growth retardation	J:329565
	embryonic lethality between implantation and placentation	J:329565
	embryonic lethality during organogenesis, complete penetrance	J:329565

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23