Ppox
Gene Detail

Symbol Name ID

Ppox protoporphyrinogen oxidase MGI:104968

Feature Type

protein coding gene

Genetic Map

Chromosome 1

79.30 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:171275990-171281186 bp, - strand From VEGA annotation of GRCm38   5197 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:262  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: protoporphyrinogen IX oxidase, aerobic
Gene Tree: Ppox

Human homologs

Human Homolog		PPOX, protoporphyrinogen oxidase
NCBI Gene ID		5498
neXtProt AC		NX_P50336
Human Synonyms		PPO, V290M, VP
Human Chr (Location)		1q22; chr1:161136181-161141010 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PPOX

Alleles and phenotypes

All alleles(7) : Targeted(1) Gene trapped(6)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	heme biosynthetic process, oxidation-reduction process, ...
Component	integral to mitochondrial inner membrane, intrinsic to mitochondrial inner membrane, ...
Function	oxidoreductase activity, oxygen-dependent protoporphyrinogen oxidase activity

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (139)    Tissues (138)    Images (11)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	93
RT-PCR	46

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000021555 (Evidence)
Ensembl Gene Model	ENSMUSG00000062729 (Evidence)
Entrez Gene	19044 (Evidence)
NIA Mouse Gene Index	U090241
EC	1.3.3.4
Consensus CDS Project	CCDS15487.1
International Mouse Knockout Project Status	Ppox

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021555	VEGA Gene Model | MGI Sequence Detail	5197	C57BL/6J
transcript	OTTMUST00000051129	VEGA | MGI Sequence Detail	1821	Not Applicable
polypeptide	OTTMUSP00000024018	VEGA | MGI Sequence Detail	477	Not Applicable

All sequences(37) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(49 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002937	Amine oxidase
InterPro	IPR016040	NAD(P)-binding domain
InterPro	IPR004572	Protoporphyrinogen oxidase
Protein Ontology	PR:000013102	protoporphyrinogen oxidase

References

(Earliest) J:113708 Ferreira GC, et al., Organization of the terminal two enzymes of the heme biosynthetic pathway. Orientation of protoporphyrinogen oxidase and evidence for a membrane complex. J Biol Chem. 1988 Mar 15;263(8):3835-9
(Latest) J:163355 Tallack MR, et al., A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Genome Res. 2010 Aug;20(8):1052-63
All references(34)

Other accession IDs

MGD-MRK-31041