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Ppox
Gene Detail
 Symbol
Name
ID
Ppox
protoporphyrinogen oxidase
MGI:104968
Feature Type protein coding gene
Genetic Map
Chromosome 1
79.30 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:171275990-171281186 bp, - strand
From VEGA annotation of GRCm38

  5197 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:262  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: protoporphyrinogen IX oxidase, aerobic
Gene Tree: Ppox

Human
homologs
Human Homolog PPOX, protoporphyrinogen oxidase
NCBI Gene ID 5498
neXtProt AC  NX_P50336
Human Synonyms  PPO, V290M, VP
Human Chr (Location)  1q22; chr1:161166391-161177098 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PPOX
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(6) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ppox interacts with 18 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process heme biosynthetic process, oxidation-reduction process, ...
Component integral component of mitochondrial inner membrane, intrinsic component of mitochondrial inner membrane, ...
Function oxidoreductase activity, oxygen-dependent protoporphyrinogen oxidase activity
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (139)    Tissues (138)    Images (11)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 93
RT-PCR 46
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000021555 (Evidence)
Ensembl Gene ModelENSMUSG00000062729 (Evidence)
Entrez Gene19044 (Evidence)
NIA Mouse Gene IndexU090241
EC1.3.3.4
Consensus CDS ProjectCCDS15487.1
International Mouse Knockout Project StatusPpox
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021555 VEGA Gene Model | MGI Sequence Detail 5197 C57BL/6J ±  kb
transcript OTTMUST00000051129 VEGA | MGI Sequence Detail 1821 Not Applicable 
polypeptide OTTMUSP00000024018 VEGA | MGI Sequence Detail 477 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002937 Amine oxidase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR004572 Protoporphyrinogen oxidase
InterPro IPR027418 Protoporphyrinogen oxidase, C-terminal domain
Protein Ontology PR:000013102 protoporphyrinogen oxidase
References (Earliest) J:113708 Ferreira GC, et al., Organization of the terminal two enzymes of the heme biosynthetic pathway. Orientation of protoporphyrinogen oxidase and evidence for a membrane complex. J Biol Chem. 1988 Mar 15;263(8):3835-9
(Latest) J:163355 Tallack MR, et al., A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Genome Res. 2010 Aug;20(8):1052-63
All references(34)
Other
accession IDs
MGD-MRK-31041

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory