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Targeted Allele Detail
Symbol: Ppoxtm1.1Had
Name: protoporphyrinogen oxidase; targeted mutation 1.1, Harry A Dailey
MGI ID: MGI:5697201
Synonyms: R59W/lox, VP/lox
Gene: Ppox  Location: Chr1:171104564-171108955 bp, - strand  Genetic Position: Chr1, 79.3 cM, cytoband H2
Alliance: Ppoxtm1.1Had page
Germline Transmission:  Earliest citation of germline transmission: J:226160
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Humanized sequence, Hypomorph)
Mutation:    Nucleotide substitutions
Mutation detailsA single codon was mutagenized to replace the arginine at amino acid 59 with tryptophan, mimicking the predominant variegate porphyria mutation in the South African population. Cre-mediated recombination was used to delete the loxP flanked neomycin selection cassette that had been inserted into intron 2. (J:226160)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppox Mutation:  26 strains or lines available
Original:  J:226160 Medlock AE, et al., A mouse model for South African (R59W) variegate porphyria: construction and initial characterization. Cell Mol Biol (Noisy-le-grand). 2002 Feb;48(1):71-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory