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Atp6v0a2 Gene Detail
Summary
  • Symbol
    Atp6v0a2
  • Name
    ATPase, H+ transporting, lysosomal V0 subunit A2
  • Synonyms
    8430408C20Rik, ATP6a2, Atp6n2, Tj6, TJ6s, V-ATPase a2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104855
    NCBI Gene: 21871
  • Gene Overview
    MyGene.info: ATP6V0A2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:124629052-124724455 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 63.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    126 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104855
protein coding gene Chr5:124628576-124724455 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030103
protein coding gene Chr5:128466923-128503346 (+)
A/J MGP_AJ_G0030068
protein coding gene Chr5:123105762-123140285 (+)
AKR/J MGP_AKRJ_G0030004
protein coding gene Chr5:127076822-127113811 (+)
BALB/cJ MGP_BALBcJ_G0030079
protein coding gene Chr5:124444448-124478560 (+)
C3H/HeJ MGP_C3HHeJ_G0029796
protein coding gene Chr5:127688903-127724394 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030532
protein coding gene Chr5:133457212-133492589 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027758
protein coding gene Chr5:117643933-117676449 (+)
CAST/EiJ MGP_CASTEiJ_G0029205
protein coding gene Chr5:126805785-126840574 (+)
CBA/J MGP_CBAJ_G0029766
protein coding gene Chr5:138669674-138703696 (+)
DBA/2J MGP_DBA2J_G0029916
protein coding gene Chr5:123125282-123159668 (+)
FVB/NJ MGP_FVBNJ_G0029872
protein coding gene Chr5:122171010-122205061 (+)
LP/J MGP_LPJ_G0030005
protein coding gene Chr5:128996586-129030982 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029903
protein coding gene Chr5:142234727-142271042 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030573
protein coding gene Chr5:126696668-126734070 (+)
PWK/PhJ MGP_PWKPhJ_G0028919
protein coding gene Chr5:121950345-121984869 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028756
protein coding gene Chr5:124330027-124365326 (+)
WSB/EiJ MGP_WSBEiJ_G0029279
protein coding gene Chr5:127383329-127421234 (+)



Homology
more
  • Human Ortholog
    ATP6V0A2, ATPase H+ transporting V0 subunit a2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATP6V0A2, ATPase H+ transporting V0 subunit a2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS
  • Links
    NCBI Gene ID: 23545
    neXtProt AC: NX_Q9Y487
    UniProt: Q9Y487

  • Chr Location
    12q24.31; chr12:123712318-123761755 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ATP6V0A2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21871 NCBI Gene Model | MGI Sequence Detail 95404 C57BL/6J ±  kb
    transcript NM_011596 RefSeq | MGI Sequence Detail 5357 C57BL/6  
    polypeptide P15920 UniProt | EBI | MGI Sequence Detail 856 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004472 V-type proton ATPase 116 kDa subunit a isoform 2
    • PDB
    • InterPro Domains
      IPR026028 ATPase, V0 complex, subunit 116kDa, eukaryotic
      IPR002490 V-type ATPase, V0 complex, 116kDa subunit family
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 17
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-28152, MGI:1918750, MGI:2140849, MGI:2141195, MGI:2141277
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 12
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:274049 Katara GK, et al., Mammary epithelium-specific inactivation of V-ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer. Mol Oncol. 2018 Feb;12(2):208-223

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory