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Atp6v0a2
Gene Detail
 Symbol
Name
ID
Atp6v0a2
ATPase, H+ transporting, lysosomal V0 subunit A2
MGI:104855
Synonyms 8430408C20Rik, ATP6a2, Atp6n2, Tj6, TJ6s, V-ATPase a2
Feature Type protein coding gene
Genetic Map
Chromosome 5
63.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:124629067-124722144 bp, + strand
From Ensembl annotation of GRCm38

  93078 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56523  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: V-type proton ATPase 116 kda subunit a isoform 1
Gene Tree: Atp6v0a2

Human
homologs
Human Homolog ATP6V0A2, ATPase, H+ transporting, lysosomal V0 subunit A2
NCBI Gene ID 23545
neXtProt AC  NX_Q9Y487
Human Synonyms  A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS
Human Chr (Location)  12q24.31; chr12:123712318-123761755 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ATP6V0A2
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process ATP hydrolysis coupled proton transport, ion transport, ...
Component acrosomal vesicle, cytoplasm, ...
Function hydrogen ion transmembrane transporter activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (310)    Tissues (141)    Images (30)
Theiler Stages: 1, 2, 3, 5, 10, 15, 18, 19, 20, 21, 22, 23, 25, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 227
Northern blot 22
Western blot 10
RT-PCR 28
RNase protection 21
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000038023 (Evidence)
Entrez Gene21871 (Evidence)
DFCITC1574260, TC1586930, TC1605638, TC1643323, TC1769272
NIA Mouse Gene IndexU136624
PDB2LX4
International Mouse Knockout Project StatusAtp6v0a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038023 Ensembl Gene Model | MGI Sequence Detail 93078 C57BL/6J ±  kb
transcript ENSMUST00000037865 Ensembl | MGI Sequence Detail 3019 Not Applicable 
polypeptide ENSMUSP00000039737 Ensembl | MGI Sequence Detail 856 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(122 from dbSNP Build 137)    SNPs within 2kb including multiple locations(126)
Protein-related
information
ResourceIDDescription
InterPro IPR002490 ATPase, V0 complex, subunit 116kDa
InterPro IPR026028 ATPase, V0 complex, subunit 116kDa, eukaryotic
Protein Ontology PR:000004472 V-type proton ATPase 116 kDa subunit a isoform 2
References (Earliest) J:30662 Lee C, et al., Cloning of a cDNA for a T cell produced molecule with a putative immune regulatory role. Mol Immunol. 1990 Nov;27(11):1137-44
(Latest) J:197103 Hosokawa H, et al., The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2. J Biol Chem. 2013 Feb 22;288(8):5896-913
All references(46)
Other
accession IDs
MGD-MRK-28152, MGI:1918750, MGI:2140849, MGI:2141195, MGI:2141277

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory