Atp6v0a2
Gene Detail

Symbol Name ID

Atp6v0a2 ATPase, H+ transporting, lysosomal V0 subunit A2 MGI:104855

Synonyms

8430408C20Rik, ATP6a2, Atp6n2, Tj6, TJ6s, V-ATPase a2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

63.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:124629067-124722144 bp, + strand From Ensembl annotation of GRCm38   93078 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56523  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: V-type proton ATPase 116 kda subunit a isoform 1
Gene Tree: Atp6v0a2

Human homologs

Human Homolog		ATP6V0A2, ATPase, H+ transporting, lysosomal V0 subunit A2
NCBI Gene ID		23545
neXtProt AC		NX_Q9Y487
Human Synonyms		A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS
Human Chr (Location)		12q24.31; chr12:124196865-124246302 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ATP6V0A2

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	ATP hydrolysis coupled proton transport, ion transport, ...
Component	acrosomal vesicle, cytoplasm, ...
Function	hydrogen ion transmembrane transporter activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (310)    Tissues (141)    Images (30)
Theiler Stages: 1, 2, 3, 5, 10, 15, 18, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	227
Northern blot	22
Western blot	10
RT-PCR	28
RNase protection	21

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000038023 (Evidence)
Entrez Gene	21871 (Evidence)
DFCI	TC1574260, TC1586930, TC1605638, TC1643323, TC1769272
NIA Mouse Gene Index	U136624
International Mouse Knockout Project Status	Atp6v0a2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000038023	Ensembl Gene Model | MGI Sequence Detail	93078	C57BL/6J
transcript	ENSMUST00000037865	Ensembl | MGI Sequence Detail	3019	Not Applicable
polypeptide	ENSMUSP00000039737	Ensembl | MGI Sequence Detail	856	Not Applicable

All sequences(48) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(73 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002490	ATPase, V0/A0 complex subunit a
InterPro	IPR026028	V-type proton ATPase subunit a
Protein Ontology	PR:000004472	V-type proton ATPase 116 kDa subunit a isoform 2

References

(Earliest) J:30662 Lee C, et al., Cloning of a cDNA for a T cell produced molecule with a putative immune regulatory role. Mol Immunol. 1990 Nov;27(11):1137-44
(Latest) J:185213 Jaiswal MK, et al., V-ATPase upregulation during early pregnancy: a possible link to establishment of an inflammatory response during preimplantation period of pregnancy. Reproduction. 2012 May;143(5):713-25
All references(45)

Other accession IDs

MGD-MRK-28152, MGI:1918750, MGI:2140849, MGI:2141195, MGI:2141277