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Hnrnpl
Gene Detail
 Symbol
Name
ID
Hnrnpl
heterogeneous nuclear ribonucleoprotein L
MGI:104816
Synonyms D830027H13Rik, Hnrpl
Feature Type protein coding gene
Genetic Map
Chromosome 7
16.93 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:28808541-28822266 bp, + strand
From VEGA annotation of GRCm38

  13726 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1174  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Hnrnpl

Human
homologs
Human Homolog HNRNPL, heterogeneous nuclear ribonucleoprotein L
NCBI Gene ID 3191
neXtProt AC  NX_P14866
Human Synonyms  hnRNP-L, HNRPL
Human Chr (Location)  19q13.2; chr19:38836388-38852339 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(76) : Gene trapped(73) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit embryonic letahlity after E3.5. Mice homozygous for a conditional allele activated in thymocytes exhibit decreased T cells in the periphery associated with impaired thymocyte chemotaxis.
 
Interactions
Hnrnpl interacts with 238 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process mRNA processing
Component cytoplasm, extracellular vesicular exosome, ...
Function nucleic acid binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (29)    Tissues (27)    Images (8)
Theiler Stages: 15, 21, 27
Assay TypeResults
RNA in situ 25
RT-PCR 4
cDNA source data(146)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(148) cDNA(146) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037299 (Evidence)
Ensembl Gene ModelENSMUSG00000015165 (Evidence)
Entrez Gene15388 (Evidence)
UniGene9043
DFCITC1574112, TC1587749
DoTSDT.101735242, DT.55223425, DT.91431333, DT.97392713
NIA Mouse Gene IndexU126116
PDB3TYT, 3S01
Consensus CDS ProjectCCDS39864.2
International Mouse Knockout Project StatusHnrnpl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037299 VEGA Gene Model | MGI Sequence Detail 13726 C57BL/6J ±  kb
transcript OTTMUST00000096250 VEGA | MGI Sequence Detail 2180 Not Applicable 
polypeptide OTTMUSP00000053750 VEGA | MGI Sequence Detail 615 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(13) UniProt(9)
Polymorphisms SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006536 HnRNP-L/PTB/hephaestus splicing factor
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000008670 heterogeneous nuclear ribonucleoprotein L
References (Earliest) J:23142 Ferreira J, et al., The biogenesis of the coiled body during early mouse development. Development. 1995 Feb;121(2):601-12
(Latest) J:200242 Peddigari S, et al., hnRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition. Nucleic Acids Res. 2013 Jan 7;41(1):575-85
All references(46)
Other
accession IDs
MGD-MRK-28110, MGI:2142336, MGI:2445140

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory