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Pea15a
Gene Detail
Symbol

Name
ID
Pea15a
phosphoprotein enriched in astrocytes 15A
MGI:104799
Synonyms
Mat1, Pea15, PEA-15, PED, Pkcs15
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr1:172196728-172206804 bp, - strand
From VEGA annotation of GRCm38

  10077 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7884  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: astrocytic phosphoprotein PEA-15
Gene Tree: Pea15a

Human
homologs
Human Homolog PEA15, phosphoprotein enriched in astrocytes 15
NCBI Gene ID 8682
neXtProt AC  NX_Q15121
Human Synonyms  HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED
Human Chr (Location)  1q21.1; chr1:160205335-160215372 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
 
Homozygous null mice exhibit reduced body weight. Although Tnfa-induced apoptosis was increased in astrocytes in vitro, glial cell and brain morphology is normal.
 
Interactions
Pea15a interacts with 341 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process apoptotic process, carbohydrate transport, ...
Component cytoplasm, intracellular, ...
Function protein kinase C binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (151)    Tissues (45)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 105
Northern blot 2
Western blot 37
RT-PCR 7
cDNA source data(286)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(313) Genomic(25) cDNA(286) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022139 (Evidence)
Ensembl Gene ModelENSMUSG00000013698 (Evidence)
Entrez Gene18611 (Evidence)
UniGene544
DFCITC1573106
NIA Mouse Gene IndexU022066
PDB2LS7
Consensus CDS ProjectCCDS15510.1
International Mouse Knockout Project StatusPea15a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022139 VEGA Gene Model | MGI Sequence Detail 10077 C57BL/6J ±  kb
transcript OTTMUST00000052554 VEGA | MGI Sequence Detail 2501 Not Applicable 
polypeptide OTTMUSP00000024937 VEGA | MGI Sequence Detail 130 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001875 Death effector domain
InterPro IPR011029 Death-like domain
Protein Ontology PR:000012530 astrocytic phosphoprotein PEA-15
References
(Earliest) J:20993 Bera TK, et al., Identification of a mammary transforming gene (MAT1) associated with mouse mammary carcinogenesis. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9789-93
(Latest) J:181946 Mergenthaler P, et al., Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1518-23
All references(53)
Other
accession IDs
MGD-MRK-25622, MGD-MRK-27038, MGD-MRK-28091, MGI:104675

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory