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Pea15a Gene Detail
Summary
  • Symbol
    Pea15a
  • Name
    phosphoprotein enriched in astrocytes 15A
  • Synonyms
    Mat1, Pea15, PEA-15, PED, Pkcs15
  • Feature Type
    protein coding gene
  • IDs
    MGI:104799
    NCBI Gene: 18611
  • Gene Overview
    MyGene.info: PEA15
Location & Maps
more
  • Sequence Map
    Chr1:172196728-172206804 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10077 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.54 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    PEA15, phosphoprotein enriched in astrocytes 15
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PEA15, phosphoprotein enriched in astrocytes 15
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED
  • Links
    NCBI Gene ID: 8682
    neXtProt AC: NX_Q15121

  • Chr Location
    1q21.1; chr1:160205319-160215376 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Gene trapped
    5
  • Targeted
    3
  • Genomic Mutations
    2 involving Pea15a
Homozygous null mice exhibit reduced body weight. Although Tnfa-induced apoptosis was increased in astrocytes in vitro, glial cell and brain morphology is normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022139 VEGA Gene Model | MGI Sequence Detail 10077 C57BL/6J ±  kb
transcript OTTMUST00000052554 VEGA | MGI Sequence Detail 2501 Not Applicable  
polypeptide OTTMUSP00000024937 VEGA | MGI Sequence Detail 130 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    118 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 313
    Genomic 25
    cDNA 286
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-25622, MGD-MRK-27038, MGD-MRK-28091, MGI:104675
References
more
  • Summaries
    All 51
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:20993 Bera TK, et al., Identification of a mammary transforming gene (MAT1) associated with mouse mammary carcinogenesis. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9789-93
  • Latest
    J:225128 Fiory F, et al., PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1. PLoS One. 2014;9(12):e113655

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory