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Myo6
Gene Detail
Symbol

Name
ID
Myo6
myosin VI
MGI:104785
Synonyms
Tlc
Feature Type
protein coding gene
Genetic Map
Chromosome 9
43.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr9:80165031-80311729 bp, + strand
From VEGA annotation of GRCm38

  146699 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56417  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Myo6

Human
homologs
Human Homolog MYO6, myosin VI
NCBI Gene ID 4646
neXtProt AC  NX_Q9UM54
Human Synonyms  DFNA22, DFNB37
Human Chr (Location)  6q13; chr6:75749176-75919537 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human MYO6
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Chemically induced (ENU)(5) Gene trapped(6) Radiation induced(1) Spontaneous(3) Targeted(4)
Genomic Mutations involving Myo6 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit deafness and related behavioral characteristics such as circling, head tossing and hyperactivity. Progressive degeneration of the cochlear hair cells and the organ of Corti is observed with one mutation.
 
Human Diseases Modeled Using Mouse Myo6 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Myo6 interacts with 355 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process auditory receptor cell differentiation, cellular response to electrical stimulus, ...
Component apical part of cell, axon, ...
Function actin binding, actin filament binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (54 records)
Data Summary: Results (62)    Tissues (31)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 58
RT-PCR 4
cDNA source data(100)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(116) Genomic(5) cDNA(102) Primer pair(6) Other(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000017558 (Evidence)
Ensembl Gene ModelENSMUSG00000033577 (Evidence)
Entrez Gene17920 (Evidence)
UniGene4040
DFCITC1580497, TC1633683, TC1652580, TC1709694, TC1711194
DoTSDT.525046, DT.91447711, DT.94257737
NIA Mouse Gene IndexU043014
PDB2KIA, 3H8D, 2LD3
Consensus CDS ProjectCCDS23368.1
International Mouse Knockout Project StatusMyo6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017558 VEGA Gene Model | MGI Sequence Detail 146699 C57BL/6J ±  kb
transcript OTTMUST00000117919 VEGA | MGI Sequence Detail 4139 Not Applicable 
polypeptide OTTMUSP00000065864 VEGA | MGI Sequence Detail 1294 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(13) UniProt(19)
Polymorphisms
All PCR and RFLP(11) : PCR(8) RFLP(3) SNPs within 2kb(1904 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010868 myosin-VI
References
(Earliest) J:26341 Dickie MM, New mutant - achondroplasia - cn. Mouse News Lett. 1960;23:34
(Latest) J:210680 Rudnicki A, et al., microRNA-224 regulates Pentraxin 3, a component of the humoral arm of innate immunity, in inner ear inflammation. Hum Mol Genet. 2014 Jun 15;23(12):3138-46
All references(141)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14657, MGD-MRK-28077, MGI:1891332, MGI:2670991

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory