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Myo6 Gene Detail
Summary
  • Symbol
    Myo6
  • Name
    myosin VI
  • Synonyms
    Myo6rsv, rsv, Tlc
  • Feature Type
    protein coding gene
  • IDs
    MGI:104785
    NCBI Gene: 17920
  • Gene Overview
    MyGene.info: MYO6
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:80165031-80311729 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      146699 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 43.98 cM
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    MYO6, myosin VI
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYO6, myosin VI
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DFNA22, DFNB37, Myo6-007, Myo6-008
  • Links
    NCBI Gene ID: 4646
    neXtProt AC: NX_Q9UM54
    UniProt: Q9UM54

  • Chr Location
    6q14.1; chr6:75749176-75919537 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56417
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MYO6
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Myo6 mouse models; 2 with human MYO6 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 11 alleles in 14 genetic backgrounds
    9 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit deafness and related behavioral characteristics such as circling, head tossing and hyperactivity. Progressive degeneration of the cochlear hair cells and the organ of Corti is observed with one mutation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017558 VEGA Gene Model | MGI Sequence Detail 146699 C57BL/6J ±  kb
    transcript OTTMUST00000117919 VEGA | MGI Sequence Detail 4139 Not Applicable  
    polypeptide OTTMUSP00000065864 VEGA | MGI Sequence Detail 1294 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1882 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 118
      Genomic 6
      cDNA 102
      Primer pair 7
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-14657, MGD-MRK-28077, MGI:1891332, MGI:2670991, MGI:6160068
    References
    more
    • Summaries
      All 176
      Developmental Gene Expression 75
      Diseases 1
      Gene Ontology 20
      Phenotypes 47
    • Earliest
      J:5044 Deol MS, et al., Snell's waltzer, a new mutation affecting behaviour and the inner ear in the mouse. Genet Res. 1966 Dec;8(3):339-45
    • Latest
      J:258772 Kruppa AJ, et al., Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria. Dev Cell. 2018 Feb 26;44(4):484-499.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory