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Myo6
Gene Detail
Symbol

Name
ID
Myo6
myosin VI
MGI:104785
Synonyms
Tlc
Feature Type
protein coding gene
Genetic Map
Chromosome 9
43.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr9:80165031-80311729 bp, + strand
From VEGA annotation of GRCm38

  146699 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56417  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYO6
Gene Tree: Myo6

Human
homologs
MYO6, myosin VI
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4646
neXtProt AC: NX_Q9UM54

Human Synonyms: DFNA22, DFNB37

Human Chr (Location): 6q13; chr6:75749176-75919537 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human MYO6

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Chemically induced (ENU)(6) Gene trapped(6) Radiation induced(1) Spontaneous(3) Targeted(4)
Genomic Mutations involving Myo6 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit deafness and related behavioral characteristics such as circling, head tossing and hyperactivity. Progressive degeneration of the cochlear hair cells and the organ of Corti is observed with one mutation.
 
Human Diseases Modeled in Mice Using Myo6 (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Myo6 interacts with 354 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (72 annotations)
Process auditory receptor cell differentiation, cellular response to electrical stimulus, ...
Component apical part of cell, axon, ...
Function actin binding, actin filament binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (59 records)
Data Summary: Results (62)    Tissues (31)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 58
RT-PCR 4
cDNA source data(100)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase myo6 ; ZFIN myo6a, myo6b    NEW 
Molecular
reagents
All nucleic(116) Genomic(5) cDNA(102) Primer pair(6) Other(3)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000017558 (Evidence)
Ensembl Gene Model ENSMUSG00000033577 (Evidence)
Entrez Gene 17920 (Evidence)
UniGene 4040
DFCI TC1652580, TC1633683, TC1580497, TC1711194, TC1709694
DoTS DT.91447711, DT.525046, DT.94257737
NIA Mouse Gene Index U043014
PDB 3H8D, 2KIA, 2LD3
Consensus CDS Project CCDS23368.1
International Mouse Phenotyping Consortium Status Myo6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017558 VEGA Gene Model | MGI Sequence Detail 146699 C57BL/6J ±  kb
transcript OTTMUST00000117919 VEGA | MGI Sequence Detail 4139 Not Applicable 
polypeptide OTTMUSP00000065864 VEGA | MGI Sequence Detail 1294 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(19) UniProt(10)
Polymorphisms
All PCR and RFLP(11) : PCR(8) RFLP(3) SNPs within 2kb(1904 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010868 myosin-VI
References
(Earliest) J:26341 Dickie MM, New mutant - achondroplasia - cn. Mouse News Lett. 1960;23:34
(Latest) J:219877 Lv K, et al., Trip6 promotes dendritic morphogenesis through dephosphorylated GRIP1-dependent myosin VI and F-actin organization. J Neurosci. 2015 Feb 11;35(6):2559-71
All references(148)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14657, MGD-MRK-28077, MGI:1891332, MGI:2670991

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory