Automated description from the Alliance of Genome Resources (Release 7.1.0)
Predicted to enable actin filament binding activity; identical protein binding activity; and microfilament motor activity. Involved in postsynaptic neurotransmitter receptor internalization; presynaptic modulation of chemical synaptic transmission; and protein localization. Acts upstream of or within several processes, including cellular response to electrical stimulus; inner ear development; and nervous system development. Located in several cellular components, including brush border; neuronal cell body; and perinuclear region of cytoplasm. Is active in several cellular components, including Schaffer collateral - CA1 synapse; cochlear hair cell ribbon synapse; and postsynaptic actin cytoskeleton. Is expressed in cerebral cortex ventricular layer; ear; heart; skeletal muscle; and stomach. Used to study autosomal dominant nonsyndromic deafness 22 and autosomal recessive nonsyndromic deafness 37. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI).
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