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Plcb3
Gene Detail
 Symbol
Name
ID
Plcb3
phospholipase C, beta 3
MGI:104778
Feature Type protein coding gene
Genetic Map
Chromosome 19
5.10 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr19:6953713-6969752 bp, - strand
From NCBI annotation of GRCm38

  16040 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta
Gene Tree: Plcb3

Human
homologs
Human Homolog PLCB3, phospholipase C, beta 3 (phosphatidylinositol-specific)
NCBI Gene ID 5331
neXtProt AC  NX_Q01970
Human Chr (Location)  11q13; chr11:64251523-64269452 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(14) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one targeted mutation die at E2.5 and exhibit poor embryonic organization and hypocellularity. Mice homozygous for a second targeted mutation survive to adulthood and exhibit an increased antinocieptive response to opioids.
 
Interactions
Plcb3 interacts with 74 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process G-protein coupled receptor signaling pathway, intracellular signal transduction, ...
Component cytosol, nucleus, ...
Function calcium ion binding, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (155)    Tissues (115)    Images (25)
Theiler Stages: 2, 7, 10, 20, 21, 22, 23, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 141
Western blot 8
RT-PCR 2
cDNA source data(62)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) Genomic(1) cDNA(63) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024960 (Evidence)
Entrez Gene18797 (Evidence)
UniGene273204
DFCITC1576650, TC1707422, TC1711989
DoTSDT.101342411, DT.110861242, DT.531589, DT.91559211, DT.94182212
NIA Mouse Gene IndexU038667
EC3.1.4.11
Consensus CDS ProjectCCDS70925.1
International Mouse Knockout Project StatusPlcb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18797 NCBI Gene Model | MGI Sequence Detail 16040 C57BL/6J ±  kb
transcript NM_008874 RefSeq | MGI Sequence Detail 4273 C57BL/6 
polypeptide P51432 UniProt | EBI | MGI Sequence Detail 1234 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR011992 EF-hand-like domain
InterPro IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
InterPro IPR009535 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site
InterPro IPR001192 Phosphoinositide phospholipase C
InterPro IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
InterPro IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
InterPro IPR014815 PLC-beta, C-terminal
InterPro IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000012830 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Graphical View of Protein Domain Structure
References (Earliest) J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
(Latest) J:208823 Ando T, et al., Critical role for mast cell Stat5 activity in skin inflammation. Cell Rep. 2014 Jan 30;6(2):366-76
All references(60)
Other
accession IDs
MGD-MRK-28070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory