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Plcb3
Gene Detail
Symbol

Name
ID
Plcb3
phospholipase C, beta 3
MGI:104778
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.10 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr19:6953714-6969759 bp, - strand
From Ensembl annotation of GRCm38

  16046 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLCB3
Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta
Gene Tree: Plcb3

Human
homologs
PLCB3, phospholipase C, beta 3 (phosphatidylinositol-specific)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5331
neXtProt AC: NX_Q01970

Human Chr (Location): 11q13; chr11:64251523-64269452 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(14) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for one targeted mutation die at E2.5 and exhibit poor embryonic organization and hypocellularity. Mice homozygous for a second targeted mutation survive to adulthood and exhibit an increased antinocieptive response to opioids.
 
Interactions
Plcb3 interacts with 74 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process G-protein coupled receptor signaling pathway, intracellular signal transduction, ...
Component cytosol, nucleoplasm, ...
Function calcium ion binding, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (155)    Tissues (115)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 141
Western blot 8
RT-PCR 2
cDNA source data(62)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase plcb3 ; ZFIN plcb3    NEW 
Molecular
reagents
All nucleic(67) Genomic(1) cDNA(63) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024960 (Evidence)
Entrez Gene 18797 (Evidence)
UniGene 273204
DFCI TC1576650, TC1707422, TC1711989
DoTS DT.101342411, DT.110861242, DT.531589, DT.91559211, DT.94182212
NIA Mouse Gene Index U038667
EC 3.1.4.11
Consensus CDS Project CCDS70925.1
International Mouse Phenotyping Consortium Status Plcb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024960 Ensembl Gene Model | MGI Sequence Detail 16046 C57BL/6J ±  kb
transcript ENSMUST00000025912 Ensembl | MGI Sequence Detail 4201 Not Applicable 
polypeptide ENSMUSP00000025912 Ensembl | MGI Sequence Detail 1234 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(10) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028390 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
InterPro IPR000008 C2 domain
InterPro IPR011992 EF-hand domain pair
InterPro IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
InterPro IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
InterPro IPR001192 Phosphoinositide phospholipase C family
InterPro IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
InterPro IPR009535 Phospholipase C-beta, conserved site
InterPro IPR014815 Phospholipase C-beta, C-terminal domain
InterPro IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Protein Ontology PR:000012830 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
References
(Earliest) J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
(Latest) J:208823 Ando T, et al., Critical role for mast cell Stat5 activity in skin inflammation. Cell Rep. 2014 Jan 30;6(2):366-76
All references(59)
Other
accession IDs
MGD-MRK-28070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory