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Plcb3 Gene Detail
Summary
  • Symbol
    Plcb3
  • Name
    phospholipase C, beta 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:104778
    NCBI Gene: 18797
  • Gene Overview
    MyGene.info: PLCB3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6953714-6969759 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.10 cM, cytoband B
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104778
protein coding gene Chr19:6953706-6974321 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024775
protein coding gene Chr19:4046717-4063601 (-)
A/J MGP_AJ_G0024741
protein coding gene Chr19:3716011-3731984 (-)
AKR/J MGP_AKRJ_G0024714
protein coding gene Chr19:3836305-3852649 (-)
BALB/cJ MGP_BALBcJ_G0024741
protein coding gene Chr19:3825407-3841452 (-)
C3H/HeJ MGP_C3HHeJ_G0024509
protein coding gene Chr19:3960591-3977934 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025187
protein coding gene Chr19:4139113-4155064 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022621
protein coding gene Chr19:3622703-3638803 (-)
CAST/EiJ MGP_CASTEiJ_G0023981
protein coding gene Chr19:3867755-3883781 (-)
CBA/J MGP_CBAJ_G0024481
protein coding gene Chr19:4188669-4206837 (-)
DBA/2J MGP_DBA2J_G0024608
protein coding gene Chr19:3688414-3704443 (-)
FVB/NJ MGP_FVBNJ_G0024574
protein coding gene Chr19:3718173-3734942 (-)
LP/J MGP_LPJ_G0024694
protein coding gene Chr19:3907154-3926072 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024603
protein coding gene Chr19:4096327-4115049 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025235
protein coding gene Chr19:3968146-3985497 (-)
PWK/PhJ MGP_PWKPhJ_G0023727
protein coding gene Chr19:3732056-3748310 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023532
protein coding gene Chr19:3791313-3808413 (-)
WSB/EiJ MGP_WSBEiJ_G0024043
protein coding gene Chr19:3872029-3889980 (-)



Homology
more
  • Human Ortholog
    PLCB3, phospholipase C beta 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PLCB3, phospholipase C beta 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 5331
    neXtProt AC: NX_Q01970
    UniProt: Q01970

  • Chr Location
    11q13.1; chr11:64251523-64269452 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one targeted mutation die at E2.5 and exhibit poor embryonic organization and hypocellularity. Mice homozygous for a second targeted mutation survive to adulthood and exhibit an increased antinocieptive response to opioids.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024960 Ensembl Gene Model | MGI Sequence Detail 16046 C57BL/6J ±  kb
    transcript ENSMUST00000025912 Ensembl | MGI Sequence Detail 4201 Not Applicable  
    polypeptide ENSMUSP00000025912 Ensembl | MGI Sequence Detail 1234 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000012830 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
    • EC
    • InterPro Domains
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR011992 EF-hand domain pair
      IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
      IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
      IPR001192 Phosphoinositide phospholipase C family
      IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
      IPR014815 Phospholipase C-beta, C-terminal domain
      IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
      IPR037862 PLC-beta, PH domain
      IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 68
      Genomic 1
      cDNA 64
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28070
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
    • Latest
      J:224889 Ip WK, et al., Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation. Nat Commun. 2015;6:6931

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory