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Erbb4 Gene Detail
Summary
  • Symbol
    Erbb4
  • Name
    erb-b2 receptor tyrosine kinase 4
  • Synonyms
    ErbB4, Her4
  • Feature Type
    protein coding gene
  • IDs
    MGI:104771
    NCBI Gene: 13869
  • Gene Overview
    MyGene.info: ERBB4
Location & Maps
more
  • Sequence Map
    Chr1:68032186-69108059 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1075874 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ERBB4, erb-b2 receptor tyrosine kinase 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ERBB4, erb-b2 receptor tyrosine kinase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALS19, HER4, p180erbB4
  • Links
    NCBI Gene ID: 2066
    neXtProt AC: NX_Q15303

  • Chr Location
    2q33.3-q34; chr2:211375717-212539155 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ERBB4 associations

Human Disease Mouse Models
       Amyotrophic Lateral Sclerosis 19; ALS19   OMIM: 615515
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 4 alleles in 5 genetic backgrounds
    30 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    2 involving Erbb4
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025138 VEGA Gene Model | MGI Sequence Detail 1075874 C57BL/6J ±  kb
transcript OTTMUST00000061852 VEGA | MGI Sequence Detail 11782 Not Applicable  
polypeptide OTTMUSP00000030426 VEGA | MGI Sequence Detail 1308 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    12002 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007160 receptor tyrosine-protein kinase erbB-4
  • EC
  • InterPro Domains
    IPR006211 Furin-like cysteine-rich domain
    IPR006212 Furin-like repeat
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR032778 Growth factor receptor domain 4
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR000494 Receptor L-domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
Molecular
Reagents
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  • All nucleic 22
    Genomic 1
    cDNA 17
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-28062
References
more
  • Summaries
    All 180
    Developmental Gene Expression 77
    Gene Ontology 17
    Phenotypes 66
  • Earliest
    J:32778 Plowman GD, et al., Heregulin induces tyrosine phosphorylation of HER4/p180erbB4. Nature. 1993 Dec 2;366(6454):473-5
  • Latest
    J:227525 Guan YF, et al., Neuregulin 1 protects against ischemic brain injury via ErbB4 receptors by increasing GABAergic transmission. Neuroscience. 2015 Oct 29;307:151-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory