Erbb4
Gene Detail

Symbol Name ID

Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) MGI:104771

Synonyms

ErbB4, Her4

Feature Type

protein coding gene

Genetic Map

Chromosome 1

33.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:68032186-69108059 bp, - strand From VEGA annotation of GRCm38   1075874 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21084  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, EGF receptor type
Gene Tree: Erbb4

Human homologs

Human Homolog		ERBB4, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
NCBI Gene ID		2066
neXtProt AC		NX_Q15303
Human Synonyms		HER4, p180erbB4
Human Chr (Location)		2q33.3-q34; chr2:212240442-213403352 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects.

 

Gene Ontology (GO) classifications

All GO classifications: (71 annotations)

Process	apoptotic process, cardiac muscle tissue regeneration, ...
Component	basolateral plasma membrane, caveola, ...
Function	ATP binding, epidermal growth factor receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (65 records)
Data Summary: Results (229)    Tissues (104)    Images (36)
Theiler Stages: 1, 2, 3, 4, 5, 12, 14, 16, 20, 23, 26

Assay Type	Results
Immunohistochemistry	6
RNA in situ	208
Western blot	7
RT-PCR	8

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(1) cDNA(16) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000025138 (Evidence)
Ensembl Gene Model	ENSMUSG00000062209 (Evidence)
Entrez Gene	13869 (Evidence)
UniGene	442420
DFCI	TC1715534
DoTS	DT.110933671, DT.94148583
NIA Mouse Gene Index	U021430
EC	2.7.10.1
Consensus CDS Project	CCDS48285.1
International Mouse Knockout Project Status	Erbb4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025138	VEGA Gene Model | MGI Sequence Detail	1075874	C57BL/6J
transcript	OTTMUST00000061852	VEGA | MGI Sequence Detail	11782	Not Applicable
polypeptide	OTTMUSP00000030426	VEGA | MGI Sequence Detail	1308	Not Applicable

All sequences(33) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(5843 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000494	EGF receptor, L domain
InterPro	IPR006211	Furin-like cysteine-rich domain
InterPro	IPR006212	Furin-like repeat
InterPro	IPR009030	Growth factor, receptor
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor
Protein Ontology	PR:000007160	receptor tyrosine-protein kinase erbB-4

References

(Earliest) J:32778 Plowman GD, et al., Heregulin induces tyrosine phosphorylation of HER4/p180erbB4. Nature. 1993 Dec 2;366(6454):473-5
(Latest) J:194074 Ahn Y, et al., Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93
All references(153)

Other accession IDs

MGD-MRK-28062