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Erbb4
Gene Detail
Symbol

Name
ID
Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
MGI:104771
Synonyms
ErbB4, Her4
Feature Type
protein coding gene
Genetic Map
Chromosome 1
33.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:68032186-69108059 bp, - strand
From VEGA annotation of GRCm38

  1075874 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21084  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ERBB4
Protein SuperFamily: tyrosine-protein kinase, EGF receptor type
Gene Tree: Erbb4

Human
homologs
ERBB4, erb-b2 receptor tyrosine kinase 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2066
neXtProt AC: NX_Q15303

Human Synonyms: ALS19, HER4, p180erbB4

Human Chr (Location): 2q33.3-q34; chr2:211375717-212539155 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ERBB4

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects.
 
Interactions
Erbb4 interacts with 564 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (73 annotations)
Process apoptotic process, cardiac muscle tissue regeneration, ...
Component basolateral plasma membrane, caveola, ...
Function ATP binding, epidermal growth factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (76 records)
Data Summary: Results (241)    Tissues (110)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 217
Western blot 9
RT-PCR 9
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase erbb4    NEW 
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000025138 (Evidence)
Ensembl Gene Model ENSMUSG00000062209 (Evidence)
Entrez Gene 13869 (Evidence)
UniGene 442420
DFCI TC1715534
DoTS DT.94148583, DT.110933671
NIA Mouse Gene Index U021430
EC 2.7.10.1
Consensus CDS Project CCDS48285.1
International Mouse Phenotyping Consortium Status Erbb4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025138 VEGA Gene Model | MGI Sequence Detail 1075874 C57BL/6J ±  kb
transcript OTTMUST00000061852 VEGA | MGI Sequence Detail 11782 Not Applicable 
polypeptide OTTMUSP00000030426 VEGA | MGI Sequence Detail 1308 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(12285 from dbSNP Build 137)    SNPs within 2kb including multiple locations(12289)
Protein-related
information
ResourceIDDescription
InterPro IPR000494 EGF receptor, L domain
InterPro IPR006211 Furin-like cysteine-rich domain
InterPro IPR006212 Furin-like repeat
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
Protein Ontology PR:000007160 receptor tyrosine-protein kinase erbB-4
References
(Earliest) J:32778 Plowman GD, et al., Heregulin induces tyrosine phosphorylation of HER4/p180erbB4. Nature. 1993 Dec 2;366(6454):473-5
(Latest) J:221815 Depboylu C, et al., Systemically administered neuregulin-1beta1 rescues nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase in MPTP mouse models of Parkinson's disease. J Neurochem. 2015 May;133(4):590-7
All references(181)
Other
accession IDs
MGD-MRK-28062

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory