About   Help   FAQ
Erbb4
Gene Detail
Symbol

Name
ID
Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
MGI:104771
Synonyms
ErbB4, Her4
Feature Type
protein coding gene
Genetic Map
Chromosome 1
33.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:68032186-69108059 bp, - strand
From VEGA annotation of GRCm38

  1075874 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21084  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, EGF receptor type
Gene Tree: Erbb4

Human
homologs
Human Homolog ERBB4, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
NCBI Gene ID 2066
neXtProt AC  NX_Q15303
Human Synonyms  ALS19, HER4, p180erbB4
Human Chr (Location)  2q33.3-q34; chr2:211375717-212539155 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ERBB4
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects.
 
Interactions
Erbb4 interacts with 565 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process apoptotic process, cardiac muscle tissue regeneration, ...
Component basolateral plasma membrane, caveola, ...
Function ATP binding, epidermal growth factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (72 records)
Data Summary: Results (241)    Tissues (110)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 217
Western blot 9
RT-PCR 9
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000025138 (Evidence)
Ensembl Gene ModelENSMUSG00000062209 (Evidence)
Entrez Gene13869 (Evidence)
UniGene442420
DFCITC1715534
DoTSDT.94148583, DT.110933671
NIA Mouse Gene IndexU021430
EC2.7.10.1
Consensus CDS ProjectCCDS48285.1
International Mouse Knockout Project StatusErbb4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025138 VEGA Gene Model | MGI Sequence Detail 1075874 C57BL/6J ±  kb
transcript OTTMUST00000061852 VEGA | MGI Sequence Detail 11782 Not Applicable 
polypeptide OTTMUSP00000030426 VEGA | MGI Sequence Detail 1308 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(12285 from dbSNP Build 137)    SNPs within 2kb including multiple locations(12289)
Protein-related
information
ResourceIDDescription
InterPro IPR000494 EGF receptor, L domain
InterPro IPR006211 Furin-like cysteine-rich domain
InterPro IPR006212 Furin-like repeat
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
Protein Ontology PR:000007160 receptor tyrosine-protein kinase erbB-4
References
(Earliest) J:32778 Plowman GD, et al., Heregulin induces tyrosine phosphorylation of HER4/p180erbB4. Nature. 1993 Dec 2;366(6454):473-5
(Latest) J:214809 Moniot B, et al., Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Development. 2014 Sep;141(18):3561-71
All references(167)
Other
accession IDs
MGD-MRK-28062

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory