Erbb4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Erbb4
erb-b2 receptor tyrosine kinase 4
MGI:104771

40 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Erbb4^{tm1.1(cre/ERT2)Aibs}/Erbb4⁺ involves: C3H * C57BL/6	no abnormal phenotype detected	J:155793
Erbb4^tm1Fej/Erbb4^tm1Fej Pvalb^tm1(cre)Arbr/Pvalb⁺ involves: 129 * C57BL/6	normal behavior/neurological phenotype	J:182690
	decreased prepulse inhibition	J:182690
	enhanced long-term potentiation	J:182690
	increased locomotor activity	J:182690
Erbb4^tm1Fej/Erbb4^tm1Fej Tg(Wap-cre)11738Mam/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal lactation	J:86319
	abnormal mammary gland development	J:86319
	abnormal mammary gland growth during lactation	J:86319
Erbb4^tm1Grl/Erbb4⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal prepulse inhibition	J:81106
	hyperactivity	J:81106
Erbb4^tm1Grl/Erbb4^tm1Grl involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal blood flow velocity	J:29972
	abnormal cranial ganglia morphology	J:29972
	abnormal cranial nerve morphology	J:29972
	abnormal facial nerve morphology	J:29972
	abnormal geniculate ganglion morphology	J:29972
	abnormal glossopharyngeal nerve morphology	J:29972
	abnormal motor neuron innervation pattern	J:29972
	abnormal sensory neuron innervation pattern	J:29972
	abnormal trigeminal ganglion morphology	J:29972
	abnormal trigeminal nerve morphology	J:29972
	abnormal vestibulocochlear ganglion morphology	J:29972
	abnormal vestibulocochlear nerve morphology	J:29972
	absent trabeculae carneae	J:29972
	decreased atrioventricular cushion size	J:29972
	embryonic lethality during organogenesis, complete penetrance	J:29972
Erbb4^tm1Htig/Erbb4^tm1Htig Myl2^tm1(cre)Krc/Myl2⁺ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	abnormal impulse conducting system conduction	J:101252
	abnormal intercalated disk morphology	J:101252
	abnormal myocardial fiber morphology	J:101252
	cardiac hypertrophy	J:101252
	decreased cardiac muscle contractility	J:101252
	decreased myocardial fiber number	J:101252
	dilated cardiomyopathy	J:101252
	dilated heart left ventricle	J:101252
	dilated heart right ventricle	J:101252
	enlarged heart	J:101252
	premature death	J:101252
	prolonged QRS complex duration	J:101252
	prolonged QT interval	J:101252
	thin ventricular wall	J:101252
	ventricular tachycardia	J:101252

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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