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Tfap2b
Gene Detail
Symbol

Name
ID
Tfap2b
transcription factor AP-2 beta
MGI:104672
Synonyms
AP-2(beta), E130018K07Rik, Tcfap2b
Feature Type
protein coding gene
Genetic Map
Chromosome 1
6.19 cM, cytoband A2-A4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:19208914-19238576 bp, + strand
From VEGA annotation of GRCm38

  29663 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20688  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TFAP2B
Gene Tree: Tfap2b

Human
homologs
TFAP2B, transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7021
neXtProt AC: NX_Q92481

Human Synonyms: AP-2B, AP2-B

Human Chr (Location): 6p12; chr6:50817710-50847619 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TFAP2B

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes have kidney cysts and show neonatal or postnatal lethality, depending on strain background. On a congenic 129P2 background, mice have tremors, polydactyly, defective tubular secretory function and ion homeostasis, hypocalcemia, hyperphosphatemia, hyperuremia, and terminal renal failure.
 
Human Diseases Modeled in Mice Using Tfap2b (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Tfap2b interacts with 386 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process aorta morphogenesis, apoptotic process, ...
Component cell, nucleus
Function chromatin binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ...
External Resources: FuncBase
Expression
Literature Summary: (51 records)
Data Summary: Results (412)    Tissues (260)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 394
RT-PCR 18
cDNA source data(58)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase tfap2b ; ZFIN tfap2b    NEW 
Molecular
reagents
All nucleic(68) Genomic(2) cDNA(60) Primer pair(4) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000048274 (Evidence)
Ensembl Gene Model ENSMUSG00000025927 (Evidence)
Entrez Gene 21419 (Evidence)
UniGene 137021
DFCI TC1583523, TC1590402, TC1593693, TC1615519
DoTS DT.101709808, DT.60117872, DT.91350349, DT.94289091
NIA Mouse Gene Index U000082
Consensus CDS Project CCDS14839.1, CCDS14840.1, CCDS78553.1
International Mouse Phenotyping Consortium Status Tfap2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048274 VEGA Gene Model | MGI Sequence Detail 29663 C57BL/6J ±  kb
transcript OTTMUST00000123883 VEGA | MGI Sequence Detail 5863 Not Applicable 
polypeptide OTTMUSP00000067531 VEGA | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(17) UniProt(6)
Polymorphisms
SNPs within 2kb(120 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004979 Transcription factor AP-2
InterPro IPR008122 Transcription factor AP-2 beta
InterPro IPR013854 Transcription factor AP-2, C-terminal
Protein Ontology PR:000016264 transcription factor AP-2-beta
References
(Earliest) J:30071 Mermod N, et al., Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature. 1988 Apr 7;332(6164):557-61
(Latest) J:221159 Stubbusch J, et al., Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol. 2015 Apr 15;400(2):210-23
All references(94)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-27035, MGI:2138300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory