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Tfap2b
Gene Detail
 Symbol
Name
ID
Tfap2b
transcription factor AP-2 beta
MGI:104672
Synonyms AP-2(beta), E130018K07Rik, Tcfap2b
Feature Type protein coding gene
Genetic Map
Chromosome 1
6.19 cM, cytoband A2-A4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:19208914-19238734 bp, + strand
From NCBI annotation of GRCm38

  29821 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20688  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tfap2b

Human
homologs
Human Homolog TFAP2B, transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
NCBI Gene ID 7021
neXtProt AC  NX_Q92481
Human Synonyms  AP-2B, AP2-B
Human Chr (Location)  6p12; chr6:50818726-50847613 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TFAP2B
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
 
Homozygotes have kidney cysts and show neonatal or postnatal lethality, depending on strain background. On a congenic 129P2 background, mice have tremors, polydactyly, defective tubular secretory function and ion homeostasis, hypocalcemia, hyperphosphatemia, hyperuremia, and terminal renal failure.
 
Human Diseases Modeled Using Mouse Tfap2b (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process aorta morphogenesis, calcium ion homeostasis, ...
Component nucleus
Function chromatin binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ...
External Resources: FuncBase
Expression
Literature Summary: (49 records)
Data Summary: Results (416)    Tissues (254)    Images (60)
Theiler Stages: 2, 3, 4, 5, 13, 15, 16, 17, 18, 19, 20, 21, 23, 24, 25, 27, 28
Assay TypeResults
RNA in situ 394
RT-PCR 22
cDNA source data(58)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(68) Genomic(2) cDNA(60) Primer pair(4) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000025927 (Evidence)
Entrez Gene21419 (Evidence)
UniGene137021
DFCITC1583523, TC1590402, TC1593693, TC1615519
DoTSDT.101709808, DT.60117872, DT.91350349, DT.94289091
NIA Mouse Gene IndexU000082
Consensus CDS ProjectCCDS14839.1, CCDS14840.1
International Mouse Knockout Project StatusTfap2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21419 NCBI Gene Model | MGI Sequence Detail 29821 C57BL/6J ±  kb
transcript NM_001025305 RefSeq | MGI Sequence Detail 6167 C57BL/6 
polypeptide Q61313 UniProt | EBI | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(17) UniProt(6)
Polymorphisms SNPs within 2kb(121 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004979 Transcription factor AP-2
InterPro IPR008122 Transcription factor AP-2 beta
InterPro IPR013854 Transcription factor AP-2, C-terminal
Protein Ontology PR:000016264 transcription factor AP-2-beta
Graphical View of Protein Domain Structure
References (Earliest) J:30071 Mermod N, et al., Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature. 1988 Apr 7;332(6164):557-61
(Latest) J:205333 Otero JJ, et al., Cerebellar cortical lamination and foliation require cyclin A2. Dev Biol. 2014 Jan 15;385(2):328-39
All references(91)
Other
accession IDs
MGD-MRK-27035, MGI:2138300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory