Tgfbr3
Gene Detail

Symbol Name ID

Tgfbr3 transforming growth factor, beta receptor III MGI:104637

Synonyms

1110036H20Rik, betaglycan, TBRIII

Feature Type

protein coding gene

Genetic Map

Chromosome 5

51.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr5:107106570-107289629 bp, - strand From VEGA annotation of GRCm38   183060 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transforming growth factor beta receptor type III
Gene Tree: Tgfbr3

Human homologs

Human Homolog		TGFBR3, transforming growth factor, beta receptor III
NCBI Gene ID		7049
neXtProt AC		NX_Q03167
Human Synonyms		betaglycan, BGCAN
Human Chr (Location)		1p33-p32; chr1:92145900-92371559 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(4) Gene trapped(6)
 

Mice homozygous for disruptions in this gene usually die as embryos. The very few individuals that survive are poorly fertile with abnormalities of the spleen, liver, heart, and skeletal system.

 

Gene Ontology (GO) classifications

All GO classifications: (74 annotations)

Process	blastocyst development, blood vessel development, ...
Component	cell surface, cytoplasm, ...
Function	activin binding, coreceptor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (279)    Tissues (49)    Images (36)
Theiler Stages: 1, 2, 3, 5, 19, 23, 25, 28

Assay Type	Results
RNA in situ	232
RT-PCR	47

cDNA source data(66)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(70) Genomic(1) cDNA(66) Primer pair(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000028168 (Evidence)
Ensembl Gene Model	ENSMUSG00000029287 (Evidence)
Entrez Gene	21814 (Evidence)
UniGene	200775
DFCI	TC1584300, TC1623850, TC1634344
DoTS	DT.530374, DT.94193849, DT.99850219
NIA Mouse Gene Index	U026513
PDB	4AJV
Consensus CDS Project	CCDS19499.1
International Mouse Knockout Project Status	Tgfbr3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028168	VEGA Gene Model | MGI Sequence Detail	183060	C57BL/6J
transcript	OTTMUST00000069768	VEGA | MGI Sequence Detail	6087	Not Applicable
polypeptide	OTTMUSP00000035486	VEGA | MGI Sequence Detail	850	Not Applicable

All sequences(39) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(1020 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001507	Zona pellucida domain
InterPro	IPR017977	Zona pellucida domain, conserved site
Protein Ontology	PR:000003110	TGF-beta receptor type-3

References

(Earliest) J:16378 Segarini PR, TGF-beta receptors: a complicated system of multiple binding proteins. Biochim Biophys Acta. 1993 Dec 23;1155(3):269-75
(Latest) J:194494 Sarraj MA, et al., Effects of TGFbeta2 on Wild-Type and Tgfbr3 Knockout Mouse Fetal Testis. Biol Reprod. 2013;88(3):66
All references(60)

Other accession IDs

MGD-MRK-26074, MGI:1921003, MGI:2141029, MGI:2141178