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Tgfbr3 Gene Detail
Summary
  • Symbol
    Tgfbr3
  • Name
    transforming growth factor, beta receptor III
  • Synonyms
    1110036H20Rik, betaglycan, TBRIII
  • Feature Type
    protein coding gene
  • IDs
    MGI:104637
    NCBI Gene: 21814
  • Gene Overview
    MyGene.info: TGFBR3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:107106570-107289629 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      183060 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 51.90 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TGFBR3, transforming growth factor beta receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TGFBR3, transforming growth factor beta receptor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    betaglycan, BGCAN
  • Links
    NCBI Gene ID: 7049
    neXtProt AC: NX_Q03167
    UniProt: Q03167

  • Chr Location
    1p22.1; chr1:91680343-91906002 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die as embryos. The very few individuals that survive are poorly fertile with abnormalities of the spleen, liver, heart, and skeletal system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000028168 VEGA Gene Model | MGI Sequence Detail 183060 C57BL/6J ±  kb
    transcript OTTMUST00000069768 VEGA | MGI Sequence Detail 6087 Not Applicable  
    polypeptide OTTMUSP00000035486 VEGA | MGI Sequence Detail 850 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1127 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • PDB
    • InterPro Domains
      IPR001507 Zona pellucida domain
      IPR017977 Zona pellucida domain, conserved site
    Molecular
    Reagents
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    • All nucleic 73
      Genomic 1
      cDNA 67
      Primer pair 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-26074, MGI:1921003, MGI:2141029, MGI:2141178
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 22
      Gene Ontology 14
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:251047 Ortega-Francisco S, et al., TbetaRIII is induced by TCR signaling and downregulated in FoxP3(+) regulatory T cells. Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):82-87

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory