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Tgfbr3
Gene Detail
Symbol

Name
ID
Tgfbr3
transforming growth factor, beta receptor III
MGI:104637
Synonyms
1110036H20Rik, betaglycan, TBRIII
Feature Type
protein coding gene
Genetic Map
Chromosome 5
51.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:107106570-107289629 bp, - strand
From VEGA annotation of GRCm38

  183060 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TGFBR3
Protein SuperFamily: transforming growth factor beta receptor type III
Gene Tree: Tgfbr3

Human
homologs
TGFBR3, transforming growth factor, beta receptor III
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7049
neXtProt AC: NX_Q03167

Human Synonyms: betaglycan, BGCAN

Human Chr (Location): 1p33-p32; chr1:91680343-91906002 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene usually die as embryos. The very few individuals that survive are poorly fertile with abnormalities of the spleen, liver, heart, and skeletal system.
 
Interactions
Tgfbr3 interacts with 406 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (87 annotations)
Process blastocyst development, blood vessel development, ...
Component cell surface, cytoplasm, ...
Function activin binding, coreceptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (299)    Tissues (52)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 232
RT-PCR 67
cDNA source data(67)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TGFBR3 ; Xenbase tgfbr3    NEW 
Molecular
reagents
All nucleic(73) Genomic(1) cDNA(67) Primer pair(5)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000028168 (Evidence)
Ensembl Gene Model ENSMUSG00000029287 (Evidence)
Entrez Gene 21814 (Evidence)
UniGene 200775
DFCI TC1634344, TC1623850, TC1584300
DoTS DT.99850219, DT.94193849, DT.530374
NIA Mouse Gene Index U026513
PDB 4AJV
Consensus CDS Project CCDS19499.1
International Mouse Phenotyping Consortium Status Tgfbr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028168 VEGA Gene Model | MGI Sequence Detail 183060 C57BL/6J ±  kb
transcript OTTMUST00000069768 VEGA | MGI Sequence Detail 6087 Not Applicable 
polypeptide OTTMUSP00000035486 VEGA | MGI Sequence Detail 850 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(1129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001507 Zona pellucida domain
InterPro IPR017977 Zona pellucida domain, conserved site
Protein Ontology PR:000003110 TGF-beta receptor type-3
References
(Earliest) J:16378 Segarini PR, TGF-beta receptors: a complicated system of multiple binding proteins. Biochim Biophys Acta. 1993 Dec 23;1155(3):269-75
(Latest) J:218259 Hill CR, et al., Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis. Dev Dyn. 2015 Feb;244(2):122-33
All references(64)
Other
accession IDs
MGD-MRK-26074, MGI:1921003, MGI:2141029, MGI:2141178

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory