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Tgfbr3 Gene Detail
Summary
  • Symbol
    Tgfbr3
  • Name
    transforming growth factor, beta receptor III
  • Synonyms
    1110036H20Rik, betaglycan, TBRIII
  • Feature Type
    protein coding gene
  • IDs
    MGI:104637
    NCBI Gene: 21814
  • Gene Overview
    MyGene.info: TGFBR3
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:107106570-107289595 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 51.90 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104637
protein coding gene Chr5:107106570-107289629 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029834
protein coding gene Chr5:109105643-109306936 (-)
A/J MGP_AJ_G0029798
protein coding gene Chr5:104931388-105122054 (-)
AKR/J MGP_AKRJ_G0029743
protein coding gene Chr5:108331399-108515026 (-)
BALB/cJ MGP_BALBcJ_G0029810
protein coding gene Chr5:106078262-106259837 (-)
C3H/HeJ MGP_C3HHeJ_G0029532
protein coding gene Chr5:108778062-108961285 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030264
protein coding gene Chr5:113605304-113802133 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027498
protein coding gene Chr5:100007353-100187394 (-)
CAST/EiJ MGP_CASTEiJ_G0028946
protein coding gene Chr5:107701069-107900963 (-)
CBA/J MGP_CBAJ_G0029500
protein coding gene Chr5:117405334-117613909 (-)
DBA/2J MGP_DBA2J_G0029646
protein coding gene Chr5:105071553-105260211 (-)
FVB/NJ MGP_FVBNJ_G0029603
protein coding gene Chr5:103807687-103992808 (-)
LP/J MGP_LPJ_G0029734
protein coding gene Chr5:109704740-109902429 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029635
protein coding gene Chr5:122351630-122550970 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030298
protein coding gene Chr5:107886447-108081215 (-)
PWK/PhJ MGP_PWKPhJ_G0028659
protein coding gene Chr5:103867300-104053060 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028497
protein coding gene Chr5:105385153-105587135 (-)
WSB/EiJ MGP_WSBEiJ_G0029019
protein coding gene Chr5:108184356-108379071 (-)



Homology
more
  • Human Ortholog
    TGFBR3, transforming growth factor beta receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TGFBR3, transforming growth factor beta receptor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    betaglycan, BGCAN
  • Links
    NCBI Gene ID: 7049
    neXtProt AC: NX_Q03167
    UniProt: Q03167

  • Chr Location
    1p22.1; chr1:91680343-91906002 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die as embryos. The very few individuals that survive are poorly fertile with abnormalities of the spleen, liver, heart, and skeletal system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21814 NCBI Gene Model | MGI Sequence Detail 183026 C57BL/6J ±  kb
    transcript NM_011578 RefSeq | MGI Sequence Detail 6090 C57BL/6  
    polypeptide O88393 UniProt | EBI | MGI Sequence Detail 850 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • PDB
    • InterPro Domains
      IPR001507 Zona pellucida domain
      IPR017977 Zona pellucida domain, conserved site
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 2
      cDNA 67
      Primer pair 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-26074, MGI:1921003, MGI:2141029, MGI:2141178
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 23
      Gene Ontology 14
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:266352 Li Y, et al., Betaglycan (TGFBR3) functions as an inhibin A, but not inhibin B, co-receptor in pituitary gonadotrope cells in mice. Endocrinology. 2018 Oct 25;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory