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Tgfbr3
Gene Detail
 Symbol
Name
ID
Tgfbr3
transforming growth factor, beta receptor III
MGI:104637
Synonyms 1110036H20Rik, betaglycan, TBRIII
Feature Type protein coding gene
Genetic Map
Chromosome 5
51.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:107106570-107289629 bp, - strand
From VEGA annotation of GRCm38

  183060 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transforming growth factor beta receptor type III
Gene Tree: Tgfbr3

Human
homologs
Human Homolog TGFBR3, transforming growth factor, beta receptor III
NCBI Gene ID 7049
neXtProt AC  NX_Q03167
Human Synonyms  betaglycan, BGCAN
Human Chr (Location)  1p33-p32; chr1:91680343-91906002 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene usually die as embryos. The very few individuals that survive are poorly fertile with abnormalities of the spleen, liver, heart, and skeletal system.
 
Interactions
Tgfbr3 interacts with 407 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (76 annotations)
Process blastocyst development, blood vessel development, ...
Component cell surface, cytoplasm, ...
Function activin binding, coreceptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (301)    Tissues (53)    Images (38)
Theiler Stages: 1, 2, 3, 5, 19, 23, 25, 26, 28
Assay TypeResults
RNA in situ 232
RT-PCR 69
cDNA source data(67)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(73) Genomic(1) cDNA(67) Primer pair(5)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000028168 (Evidence)
Ensembl Gene ModelENSMUSG00000029287 (Evidence)
Entrez Gene21814 (Evidence)
UniGene200775
DFCITC1584300, TC1623850, TC1634344
DoTSDT.530374, DT.94193849, DT.99850219
NIA Mouse Gene IndexU026513
PDB4AJV
Consensus CDS ProjectCCDS19499.1
International Mouse Knockout Project StatusTgfbr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028168 VEGA Gene Model | MGI Sequence Detail 183060 C57BL/6J ±  kb
transcript OTTMUST00000069768 VEGA | MGI Sequence Detail 6087 Not Applicable 
polypeptide OTTMUSP00000035486 VEGA | MGI Sequence Detail 850 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(1129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001507 Zona pellucida domain
InterPro IPR017977 Zona pellucida domain, conserved site
Protein Ontology PR:000003110 TGF-beta receptor type-3
References (Earliest) J:16378 Segarini PR, TGF-beta receptors: a complicated system of multiple binding proteins. Biochim Biophys Acta. 1993 Dec 23;1155(3):269-75
(Latest) J:203733 Diestel U, et al., Identification of a Novel TGF-beta-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-beta-Receptor-3 (TGFR-3). PLoS One. 2013;8(6):e67214
All references(62)
Other
accession IDs
MGD-MRK-26074, MGI:1921003, MGI:2141029, MGI:2141178

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory