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Tgfbr3 Gene Detail
Summary
  • Symbol
    Tgfbr3
  • Name
    transforming growth factor, beta receptor III
  • Synonyms
    1110036H20Rik, betaglycan, TBRIII
  • Feature Type
    protein coding gene
  • IDs
    MGI:104637
    NCBI Gene: 21814
Location & Maps
more
  • Sequence Map
    Chr5:107106570-107289629 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      183060 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TGFBR3, transforming growth factor beta receptor III
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TGFBR3, transforming growth factor beta receptor III
    Orthology source: HGNC, HomoloGene
  • Synonyms
    betaglycan, BGCAN
  • Links
    NCBI Gene ID: 7049
    neXtProt AC: NX_Q03167

  • Chr Location
    1p33-p32; chr1:91680343-91906002 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    3 involving Tgfbr3
  • Incidental Mutations
Mice homozygous for disruptions in this gene usually die as embryos. The very few individuals that survive are poorly fertile with abnormalities of the spleen, liver, heart, and skeletal system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028168 VEGA Gene Model | MGI Sequence Detail 183060 C57BL/6J ±  kb
transcript OTTMUST00000069768 VEGA | MGI Sequence Detail 6087 Not Applicable  
polypeptide OTTMUSP00000035486 VEGA | MGI Sequence Detail 850 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1129 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • PDB
  • InterPro Domains
    IPR001507 Zona pellucida domain
    IPR017977 Zona pellucida domain, conserved site
Molecular
Reagents
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  • All nucleic 73
    Genomic 1
    cDNA 67
    Primer pair 5

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-26074, MGI:1921003, MGI:2141029, MGI:2141178
References
more
  • Summaries
    All 61
    Developmental Gene Expression 19
    Gene Ontology 14
    Phenotypes 16
  • Earliest
    J:16378 Segarini PR, TGF-beta receptors: a complicated system of multiple binding proteins. Biochim Biophys Acta. 1993 Dec 23;1155(3):269-75
  • Latest
    J:218259 Hill CR, et al., Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis. Dev Dyn. 2015 Feb;244(2):122-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory