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Eps15
Gene Detail
 Symbol
Name
ID
Eps15
epidermal growth factor receptor pathway substrate 15
MGI:104583
Synonyms 2410112D09Rik
Feature Type protein coding gene
Genetic Map
Chromosome 4
51.29 cM, cytoband C7
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:109280268-109387817 bp, + strand
From VEGA annotation of GRCm38

  107550 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128359  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Eps15

Human
homologs
Human Homolog EPS15, epidermal growth factor receptor pathway substrate 15
NCBI Gene ID 2060
neXtProt AC  NX_P42566
Human Synonyms  AF1P, AF-1P, MLLT5
Human Chr (Location)  1p32; chr1:51354263-51519354 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased marginal zone B cells without defects in precursor cells, proliferation, apoptosis, migration or B cell response.
 
Interactions
Eps15 interacts with 335 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process clathrin coat assembly, endocytosis, ...
Component AP-2 adaptor complex, ciliary membrane, ...
Function calcium ion binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (158)    Tissues (53)    Images (28)
Theiler Stages: 20, 22, 23
Assay TypeResults
Immunohistochemistry 51
RNA in situ 107
cDNA source data(122)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(123) cDNA(123)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000008289 (Evidence)
Ensembl Gene ModelENSMUSG00000028552 (Evidence)
Entrez Gene13858 (Evidence)
UniGene318250
DFCITC1580136, TC1583397, TC1599823
DoTSDT.110794203, DT.533559, DT.91592340
NIA Mouse Gene IndexU004636
PDB1KYF, 1KYU, 1QJT
Consensus CDS ProjectCCDS18462.1, CCDS51259.1
International Mouse Knockout Project StatusEps15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008289 VEGA Gene Model | MGI Sequence Detail 107550 C57BL/6J ±  kb
transcript OTTMUST00000018852 VEGA | MGI Sequence Detail 2802 Not Applicable 
polypeptide OTTMUSP00000008656 VEGA | MGI Sequence Detail 933 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(10) UniProt(7)
Polymorphisms SNPs within 2kb(531 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR000261 EPS15 homology (EH)
InterPro IPR003903 Ubiquitin interacting motif
Protein Ontology PR:000007145 epidermal growth factor receptor substrate 15
References (Earliest) J:29845 Fazioli F, et al., eps15, a novel tyrosine kinase substrate, exhibits transforming activity. Mol Cell Biol. 1993 Sep;13(9):5814-28
(Latest) J:195689 Pozzi B, et al., The endocytic adaptor Eps15 controls marginal zone B cell numbers. PLoS One. 2012;7(11):e50818
All references(51)
Other
accession IDs
MGD-MRK-26017, MGI:1920919

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory