Eps15 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Eps15
epidermal growth factor receptor pathway substrate 15
MGI:104583

25 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Eps15^{tm1c(KOMP)Wtsi}/Eps15^{tm1c(KOMP)Wtsi} Eps15l1^tm1.1Noff/Eps15l1^tm1.1Noff Tg(Tek-cre)1Ywa/0 involves: C57BL/6 * C57BL/6N * SJL	abnormal vascular development	J:272122
	anisocytosis	J:272122
	decreased mean corpuscular volume	J:272122
	increased red blood cell distribution width	J:272122
	reticulocytosis	J:272122
Eps15^{tm1c(KOMP)Wtsi}/Eps15^{tm1c(KOMP)Wtsi} Eps15l1^tm2.1Noff/Eps15l1^tm2.1Noff Tg(Tek-cre)1Ywa/0 involves: C57BL/6 * C57BL/6N * SJL	abnormal endocytosis	J:272122
	abnormal erythropoiesis	J:272122
	anemia	J:272122
	anisopoikilocytosis	J:272122
	decreased erythrocyte cell number	J:272122
	decreased hematocrit	J:272122
	decreased hemoglobin content	J:272122
	decreased mean corpuscular volume	J:272122
	extramedullary hematopoiesis	J:272122
	hypochromic microcytic anemia	J:272122
	increased circulating iron level	J:272122
	reticulocytosis	J:272122
Eps15^tm1Noff/Eps15^tm1Noff Eps15l1^tm1.1Noff/Eps15l1^tm1.1Noff involves: 129 * C57BL/6	abnormal embryo morphology	J:272122
	abnormal midbrain-hindbrain boundary morphology	J:272122
	abnormal vasculogenesis	J:272122
	abnormal vitelline vasculature morphology	J:272122
	absent limb buds	J:272122
	delayed heart looping	J:272122
	embryonic growth retardation	J:272122
	embryonic lethality during organogenesis, complete penetrance	J:272122
	fused somites	J:272122
	pallor	J:272122

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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