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Cdkn1b
Gene Detail
Symbol

Name
ID
Cdkn1b
cyclin-dependent kinase inhibitor 1B
MGI:104565
Synonyms
p27, p27Kip1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
65.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:134920401-134925513 bp, + strand
From VEGA annotation of GRCm38

  5113 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2999  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: cyclin-dependent kinase inhibitor p27
Gene Tree: Cdkn1b

Human
homologs
Human Homolog CDKN1B, cyclin-dependent kinase inhibitor 1B (p27, Kip1)
NCBI Gene ID 1027
neXtProt AC  NX_P46527
Human Synonyms  CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Human Chr (Location)  12p13.1-p12; chr12:12717368-12722371 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CDKN1B
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(2) Targeted(12)
 
Homozygous mutants have increased body weight, enlargement of major organs, impaired hearing and increased tumor susceptibility. Females are sterile, having impaired luteal cell differentiation and disrupted estrus cycle.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Cdkn1b interacts with 366 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (262 records)
Data Summary: Results (157)    Tissues (79)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 52
RNA in situ 74
Northern blot 4
Western blot 21
RT-PCR 6
cDNA source data(39)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(1) cDNA(41) Primer pair(5)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000021172 (Evidence)
Ensembl Gene ModelENSMUSG00000003031 (Evidence)
Entrez Gene12576 (Evidence)
UniGene2958
DFCITC1583217, TC1648069
DoTSDT.101195241, DT.101206299, DT.101286162, DT.101286163, DT.40138623, DT.94249551
Consensus CDS ProjectCCDS20642.1
International Mouse Knockout Project StatusCdkn1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021172 VEGA Gene Model | MGI Sequence Detail 5113 C57BL/6J ±  kb
transcript OTTMUST00000050154 VEGA | MGI Sequence Detail 2393 Not Applicable 
polypeptide OTTMUSP00000023377 VEGA | MGI Sequence Detail 197 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(4)
Polymorphisms
PCR(2) : SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003175 Cyclin-dependent kinase inhibitor
Protein Ontology PR:000003090 cyclin-dependent kinase inhibitor 1B
References
(Earliest) J:19217 Polyak K, et al., Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994 Jul 15;78(1):59-66
(Latest) J:211957 Tane S, et al., CDK inhibitors, p21(Cip1) and p27(Kip1), participate in cell cycle exit of mammalian cardiomyocytes. Biochem Biophys Res Commun. 2014 Jan 17;443(3):1105-9
All references(548)
Other
accession IDs
MGD-MRK-25999, MGI:2141358, MGI:2141489

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory