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Cdkn1b
Gene Detail
Symbol

Name
ID
Cdkn1b
cyclin-dependent kinase inhibitor 1B
MGI:104565
Synonyms
p27, p27Kip1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
65.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:134920401-134925513 bp, + strand
From VEGA annotation of GRCm38

  5113 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2999  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: CDKN1B
Protein SuperFamily: cyclin-dependent kinase inhibitor p27
Gene Tree: Cdkn1b

Human
homologs
CDKN1B, cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1027
neXtProt AC: NX_P46527

Human Synonyms: CDKN4, KIP1, MEN1B, MEN4, P27KIP1

Human Chr (Location): 12p13.1-p12; chr12:12717270-12722383 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CDKN1B

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(2) Targeted(13) Transgenic(1)
 
Homozygous mutants have increased body weight, enlargement of major organs, impaired hearing and increased tumor susceptibility. Females are sterile, having impaired luteal cell differentiation and disrupted estrus cycle.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Cdkn1b interacts with 365 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (281 records)
Data Summary: Results (238)    Tissues (147)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 133
RNA in situ 74
Northern blot 4
Western blot 21
RT-PCR 6
cDNA source data(39)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN cdkn1ba, cdkn1bb    NEW 
Molecular
reagents
All nucleic(47) Genomic(1) cDNA(41) Primer pair(5)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000021172 (Evidence)
Ensembl Gene Model ENSMUSG00000003031 (Evidence)
Entrez Gene 12576 (Evidence)
UniGene 2958
DFCI TC1583217, TC1648069
DoTS DT.101195241, DT.101206299, DT.101286162, DT.101286163, DT.40138623, DT.94249551
Consensus CDS Project CCDS20642.1
International Mouse Phenotyping Consortium Status Cdkn1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021172 VEGA Gene Model | MGI Sequence Detail 5113 C57BL/6J ±  kb
transcript OTTMUST00000050153 VEGA | MGI Sequence Detail 4552 Not Applicable 
polypeptide OTTMUSP00000023376 VEGA | MGI Sequence Detail 197 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(4)
Polymorphisms
PCR(2) : SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003175 Cyclin-dependent kinase inhibitor
Protein Ontology PR:000003090 cyclin-dependent kinase inhibitor 1B
References
(Earliest) J:19217 Polyak K, et al., Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994 Jul 15;78(1):59-66
(Latest) J:221798 Gao Y, et al., Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells. Nat Commun. 2015;6:6328
All references(574)
Other
accession IDs
MGD-MRK-25999, MGI:2141358, MGI:2141489

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory