Cdkn1b
Gene Detail

Symbol Name ID

Cdkn1b cyclin-dependent kinase inhibitor 1B MGI:104565

Synonyms

p27, p27Kip1

Feature Type

protein coding gene

Genetic Map

Chromosome 6

65.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:134920401-134925513 bp, + strand From VEGA annotation of GRCm38   5113 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2999  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: cyclin-dependent kinase inhibitor p27
Gene Tree: Cdkn1b

Human homologs

Human Homolog		CDKN1B, cyclin-dependent kinase inhibitor 1B (p27, Kip1)
NCBI Gene ID		1027
neXtProt AC		NX_P46527
Human Synonyms		CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Human Chr (Location)		12p13.1-p12; chr12:12870302-12875305 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CDKN1B

Alleles and phenotypes

All alleles(14) : Targeted(12) Gene trapped(2)
 

Homozygous mutants have increased body weight, enlargement of major organs, impaired hearing and increased tumor susceptibility. Females are sterile, having impaired luteal cell differentiation and disrupted estrus cycle.

 

Gene Ontology (GO) classifications

All GO classifications: (52 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, autophagic cell death, ...
Component	cytoplasm, cytosol, ...
Function	chaperone binding, cyclin-dependent protein serine/threonine kinase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (240 records)
Data Summary: Results (146)    Tissues (71)    Images (49)
Theiler Stages: 9, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	45
RNA in situ	74
Northern blot	4
Western blot	21
RT-PCR	2

cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(1) cDNA(20) Primer pair(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000021172 (Evidence)
Ensembl Gene Model	ENSMUSG00000003031 (Evidence)
Entrez Gene	12576 (Evidence)
DFCI	TC1583217, TC1648069
DoTS	DT.101195241, DT.101206299, DT.101286162, DT.101286163, DT.40138623, DT.94249551
Consensus CDS Project	CCDS20642.1
International Mouse Knockout Project Status	Cdkn1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021172	VEGA Gene Model | MGI Sequence Detail	5113	C57BL/6J
transcript	OTTMUST00000050153	VEGA | MGI Sequence Detail	4552	Not Applicable
polypeptide	OTTMUSP00000023376	VEGA | MGI Sequence Detail	197	Not Applicable

All sequences(42) RefSeq(2) UniProt(4)

Polymorphisms

PCR(2) : SNPs within 2kb(37 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR003175	Cyclin-dependent kinase inhibitor
Protein Ontology	PR:000003090	cyclin-dependent kinase inhibitor 1B

References

(Earliest) J:19217 Polyak K, et al., Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994 Jul 15;78(1):59-66
(Latest) J:195854 Zhu Y, et al., Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS One. 2013;8(1):e54221
All references(508)

Other accession IDs

MGD-MRK-25999, MGI:2141358, MGI:2141489