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Cdkn1b Gene Detail
Summary
  • Symbol
    Cdkn1b
  • Name
    cyclin-dependent kinase inhibitor 1B
  • Synonyms
    p27, p27Kip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104565
    NCBI Gene: 12576
  • Gene Overview
    MyGene.info: CDKN1B
Location & Maps
more
  • Sequence Map
    Chr6:134920401-134925513 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5113 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CDKN1B, cyclin-dependent kinase inhibitor 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDKN1B, cyclin-dependent kinase inhibitor 1B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDKN4, KIP1, MEN1B, MEN4, P27KIP1
  • Links
    NCBI Gene ID: 1027
    neXtProt AC: NX_P46527

  • Chr Location
    12p13.1-p12; chr12:12717270-12722383 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CDKN1B associations

Human Disease Mouse Models
       Multiple Endocrine Neoplasia, Type IV; MEN4   OMIM: 610755
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    92 phenotypes from 10 alleles in 9 genetic backgrounds
    117 phenotypes from multigenic genotypes
    221 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Gene trapped
    2
  • Targeted
    13
  • Transgenic
    2
Homozygous mutants have increased body weight, enlargement of major organs, impaired hearing and increased tumor susceptibility. Females are sterile, having impaired luteal cell differentiation and disrupted estrus cycle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021172 VEGA Gene Model | MGI Sequence Detail 5113 C57BL/6J ±  kb
transcript OTTMUST00000050153 VEGA | MGI Sequence Detail 4552 Not Applicable  
polypeptide OTTMUSP00000023376 VEGA | MGI Sequence Detail 197 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    35 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003090 cyclin-dependent kinase inhibitor 1B
  • InterPro Domains
    IPR003175 Cyclin-dependent kinase inhibitor
    IPR029843 Cyclin-dependent kinase inhibitor 1B
Molecular
Reagents
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  • All nucleic 49
    Genomic 1
    cDNA 41
    Primer pair 7

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-25999, MGI:2141358, MGI:2141489
References
more
  • Summaries
    All 589
    Developmental Gene Expression 297
    Diseases 1
    Gene Ontology 25
    Phenotypes 221
  • Earliest
    J:19217 Polyak K, et al., Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994 Jul 15;78(1):59-66
  • Latest
    J:229460 Chaffee BR, et al., FGFR and PTEN signaling interact during lens development to regulate cell survival. Dev Biol. 2016 Feb 15;410(2):150-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory