Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including G1/S transition of mitotic cell cycle; heart development; and negative regulation of cardiac muscle tissue regeneration. Acts upstream of or within several processes, including negative regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of microtubule polymerization; and regulation of exit from mitosis. Located in cytosol and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart and pericardium; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B).