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Hand2
Gene Detail
Symbol

Name
ID
Hand2
heart and neural crest derivatives expressed transcript 2
MGI:103580
Synonyms
bHLHa26, dHAND, Ehand2, Hed, Thing2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
29.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:57320983-57324517 bp, + strand
From VEGA annotation of GRCm38

  3535 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Hand2

Human
homologs
Human Homolog HAND2, heart and neural crest derivatives expressed 2
NCBI Gene ID 9464
neXtProt AC  NX_P61296
Human Synonyms  bHLHa26, dHand, DHAND2, Hed, Thing2
Human Chr (Location)  4q33; chr4:173526501-173530227 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
 
Homozygous targeted null mutants have defects of the neural crest component of branchial and aortic arches and die from heart failure at embryonic day 10.5. Targeted branchial arch specific enhancer mutants show craniofacial defects and die perinatally.
 
Interactions
Hand2 interacts with 130 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process adult heart development, angiogenesis, ...
Component nuclear chromatin, nucleus, ...
Function activating transcription factor binding, AT DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (220 records)
Data Summary: Results (450)    Tissues (201)    Images (151)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 421
Northern blot 25
RT-PCR 4
cDNA source data(14)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(3) cDNA(18) Primer pair(4) Other(18)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000046275 (Evidence)
Ensembl Gene ModelENSMUSG00000038193 (Evidence)
Entrez Gene15111 (Evidence)
DFCITC1582014
DoTSDT.523379, DT.110906538
NIA Mouse Gene IndexU009353
Consensus CDS ProjectCCDS22315.1
International Mouse Knockout Project StatusHand2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046275 VEGA Gene Model | MGI Sequence Detail 3535 C57BL/6J ±  kb
transcript OTTMUST00000120646 VEGA | MGI Sequence Detail 2235 Not Applicable 
polypeptide OTTMUSP00000066736 VEGA | MGI Sequence Detail 217 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000008440 heart- and neural crest derivatives-expressed protein 2
References
(Earliest) J:26206 Hollenberg SM, et al., Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol Cell Biol. 1995 Jul;15(7):3813-22
(Latest) J:208894 VanDusen NJ, et al., Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death. Dev Biol. 2014 Apr 15;388(2):149-58
All references(277)
Other
accession IDs
MGD-MRK-24465, MGD-MRK-25633, MGI:104305, MGI:2142483, MGI:2142607

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory