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Hand2 Gene Detail
Summary
  • Symbol
    Hand2
  • Name
    heart and neural crest derivatives expressed transcript 2
  • Synonyms
    bHLHa26, dHAND, Ehand2, Hed, Thing2
  • Feature Type
    protein coding gene
  • IDs
    MGI:103580
    NCBI Gene: 15111
  • Gene Overview
    MyGene.info: HAND2
Location & Maps
more
  • Sequence Map
    Chr8:57320983-57324517 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3535 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 29.80 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HAND2, heart and neural crest derivatives expressed 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HAND2, heart and neural crest derivatives expressed 2
    Orthology source: HomoloGene
  • Synonyms
    bHLHa26, dHand, DHAND2, Hed, Thing2
  • Links
    NCBI Gene ID: 9464
    neXtProt AC: NX_P61296

  • Chr Location
    4q33; chr4:173526501-173530227 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    118 phenotypes from 19 alleles in 19 genetic backgrounds
    40 phenotypes from multigenic genotypes
    3 images
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    1
  • Targeted
    11
  • Transgenic
    10
  • Genomic Mutations
    1 involving Hand2
Homozygous targeted null mutants have defects of the neural crest component of branchial and aortic arches and die from heart failure at embryonic day 10.5. Targeted branchial arch specific enhancer mutants show craniofacial defects and die perinatally.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046275 VEGA Gene Model | MGI Sequence Detail 3535 C57BL/6J ±  kb
transcript OTTMUST00000120646 VEGA | MGI Sequence Detail 2235 Not Applicable  
polypeptide OTTMUSP00000066736 VEGA | MGI Sequence Detail 217 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    36 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008440 heart- and neural crest derivatives-expressed protein 2
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 45
    Genomic 3
    cDNA 18
    Primer pair 5
    Other 19

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-24465, MGD-MRK-25633, MGI:104305, MGI:2142483, MGI:2142607
References
more
  • Summaries
    All 293
    Developmental Gene Expression 240
    Gene Ontology 25
    Phenotypes 46
  • Earliest
    J:26206 Hollenberg SM, et al., Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol Cell Biol. 1995 Jul;15(7):3813-22
  • Latest
    J:230425 Bouilloux F, et al., Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory