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Hand2
Gene Detail
 Symbol
Name
ID
Hand2
heart and neural crest derivatives expressed transcript 2
MGI:103580
Synonyms bHLHa26, dHAND, Ehand2, Hed, Thing2
Feature Type protein coding gene
Genetic Map
Chromosome 8
29.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:57320983-57324517 bp, + strand
From NCBI annotation of GRCm38

  3535 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Hand2

Human
homologs
Human Homolog HAND2, heart and neural crest derivatives expressed 2
NCBI Gene ID 9464
neXtProt AC  NX_P61296
Human Synonyms  bHLHa26, dHand, DHAND2, Hed, Thing2
Human Chr (Location)  4q33; chr4:173526501-173530227 (-)  GRCh38
Alleles
and
phenotypes
All alleles(10) : Targeted(10)
 
Homozygous targeted null mutants have defects of the neural crest component of branchial and aortic arches and die from heart failure at embryonic day 10.5. Targeted branchial arch specific enhancer mutants show craniofacial defects and die perinatally.
 
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process adult heart development, angiogenesis, ...
Component nuclear chromatin, nucleus, ...
Function activating transcription factor binding, AT DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (211 records)
Data Summary: Results (440)    Tissues (196)    Images (144)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 410
Northern blot 26
RT-PCR 4
cDNA source data(14)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(41) Genomic(3) cDNA(18) Primer pair(4) Other(16)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000038193 (Evidence)
Entrez Gene15111 (Evidence)
DFCITC1582014
DoTSDT.110906538, DT.523379
NIA Mouse Gene IndexU009353
Consensus CDS ProjectCCDS22315.1
International Mouse Knockout Project StatusHand2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15111 NCBI Gene Model | MGI Sequence Detail 3535 C57BL/6J ±  kb
transcript NM_010402 RefSeq | MGI Sequence Detail 2235 C57BL/6 
polypeptide Q61039 UniProt | EBI | MGI Sequence Detail 217 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000008440 heart- and neural crest derivatives-expressed protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:26206 Hollenberg SM, et al., Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol Cell Biol. 1995 Jul;15(7):3813-22
(Latest) J:203059 Xu B, et al., Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19438-43
All references(266)
Other
accession IDs
MGD-MRK-24465, MGD-MRK-25633, MGI:104305, MGI:2142483, MGI:2142607

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory