Sequence Detail

ID/Version

Q61039 Q61100 (UniProt | EBI)

Last sequence update: 2004-05-10
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Heart- and neural crest derivatives-expressed protein 2;AltName: Full=Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; Short=dHAND;AltName: Full=Helix-loop-helix transcription factor express

Provider

SWISS-PROT

Sequence

Polypeptide 217 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hand2	heart and neural crest derivatives expressed 2	102	218	3	26

Sequence references in MGI

J:28009 Cross JC, et al., Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development. 1995 Aug;121(8):2513-23
J:35033 Srivastava D, et al., A subclass of bHLH proteins required for cardiac morphogenesis. Science. 1995 Dec 22;270(5244):1995-9
J:40768 Srivastava D, et al., Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND [see comments] [published erratum appears in Nat Genet 1997 Aug;16(4):410]. Nat Genet. 1997 Jun;16(2):154-60
J:49658 Thomas T, et al., A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development. 1998 Aug;125(16):3005-14
J:61522 Fernandez-Teran M, et al., Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the sonic hedgehog pathway. Development. 2000 May;127(10):2133-42
J:62028 Charite J, et al., The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development. Development. 2000 Jun;127(11):2461-70
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113904 Firulli BA, et al., The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. J Biol Chem. 2000 Oct 27;275(43):33567-73