Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and protein homodimerization activity. Contributes to E-box binding activity. Involved in several processes, including heart morphogenesis; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of semaphorin-plexin signaling pathway. Acts upstream of with a positive effect on norepinephrine biosynthetic process. Acts upstream of or within several processes, including heart development; negative regulation of osteoblast differentiation; and nervous system development. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and hindlimb phalanx. Orthologous to human HAND2 (heart and neural crest derivatives expressed 2).