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Ccl11
Gene Detail
Symbol

Name
ID
Ccl11
chemokine (C-C motif) ligand 11
MGI:103576
Synonyms
eotaxin, Scya11
Feature Type
protein coding gene
Genetic Map
Chromosome 11
49.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr11:82057823-82062955 bp, + strand
From VEGA annotation of GRCm38

  5133 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7929  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: small inducible chemokine, C/CC types
Gene Tree: Ccl11

Human
homologs
Human Homolog CCL11, chemokine (C-C motif) ligand 11
NCBI Gene ID 6356
neXtProt AC  NX_P51671
Human Synonyms  SCYA11
Human Chr (Location)  17q12; chr17:34285668-34288180 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human CCL11
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene display decreased numbers of eosinophils and impaired eosinophil recruitment after antigen challenge. However, a different homozygous disruption does not result in eosinophil abnormalities.
 
Interactions
Ccl11 interacts with 91 markers (Mir7-1, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(16) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000000860 (Evidence)
Ensembl Gene ModelENSMUSG00000020676 (Evidence)
Entrez Gene20292 (Evidence)
UniGene4686
DFCITC1582755
DoTSDT.50315313, DT.101362332
NIA Mouse Gene IndexU013063
Consensus CDS ProjectCCDS36246.1
International Mouse Knockout Project StatusCcl11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000860 VEGA Gene Model | MGI Sequence Detail 5133 C57BL/6J ±  kb
transcript OTTMUST00000001670 VEGA | MGI Sequence Detail 1082 Not Applicable 
polypeptide OTTMUSP00000000791 VEGA | MGI Sequence Detail 97 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000827 CC chemokine, conserved site
InterPro IPR001811 Chemokine interleukin-8-like domain
Protein Ontology PR:000002139 eotaxin
References
(Earliest) J:24553 Rothenberg ME, et al., Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung. J Exp Med. 1995 Mar 1;181(3):1211-6
(Latest) J:187918 Heller NM, et al., IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro. PLoS One. 2012;7(6):e39673
All references(76)
Other
accession IDs
MGD-MRK-24461

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory