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Ccl11 Gene Detail
Summary
  • Symbol
    Ccl11
  • Name
    chemokine (C-C motif) ligand 11
  • Synonyms
    eotaxin, Scya11
  • Feature Type
    protein coding gene
  • IDs
    MGI:103576
    NCBI Gene: 20292
  • Gene Overview
    MyGene.info: CCL11
Location & Maps
more
  • Sequence Map
    Chr11:82057823-82062955 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5133 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 49.84 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    CCL11, C-C motif chemokine ligand 11
  • Vertebrate Orthologs
    6
  • Human Ortholog
    CCL11, C-C motif chemokine ligand 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SCYA11
  • Links
    NCBI Gene ID: 6356
    neXtProt AC: NX_P51671

  • Chr Location
    17q12; chr17:34285668-34288180 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human CCL11 associations

Human Disease Mouse Models
       Asthma, Susceptibility to   OMIM: 600807
Human Immunodeficiency Virus Type 1, Susceptibility to   OMIM: 609423
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Ccl11
  • Incidental Mutations
Mice homozygous for a disruption in this gene display decreased numbers of eosinophils and impaired eosinophil recruitment after antigen challenge. However, a different homozygous disruption does not result in eosinophil abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000860 VEGA Gene Model | MGI Sequence Detail 5133 C57BL/6J ±  kb
transcript OTTMUST00000001670 VEGA | MGI Sequence Detail 1082 Not Applicable  
polypeptide OTTMUSP00000000791 VEGA | MGI Sequence Detail 97 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    22 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 2
    cDNA 16
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-24461
References
more
  • Summaries
    All 75
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 41
  • Earliest
    J:24553 Rothenberg ME, et al., Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung. J Exp Med. 1995 Mar 1;181(3):1211-6
  • Latest
    J:233073 1857225de Valle E, et al., NFkappaB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells. J Exp Med. 2016 Apr 4;213(4):621-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory