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Ccl11 Gene Detail
Summary
  • Symbol
    Ccl11
  • Name
    chemokine (C-C motif) ligand 11
  • Synonyms
    eotaxin, Scya11
  • Feature Type
    protein coding gene
  • IDs
    MGI:103576
    NCBI Gene: 20292
  • Gene Overview
    MyGene.info: CCL11
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:82057832-82062955 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 49.84 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103576
protein coding gene Chr11:82057823-82062955 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018823
protein coding gene Chr11:83301856-83309730 (+)
A/J MGP_AJ_G0018790
protein coding gene Chr11:80100777-80105853 (+)
AKR/J MGP_AKRJ_G0018760
protein coding gene Chr11:82492821-82498882 (+)
BALB/cJ MGP_BALBcJ_G0018763
protein coding gene Chr11:80494631-80499691 (+)
C3H/HeJ MGP_C3HHeJ_G0018577
protein coding gene Chr11:82544845-82549917 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019215
protein coding gene Chr11:85800043-85807786 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016849
protein coding gene Chr11:77071924-77077067 (+)
CAST/EiJ MGP_CASTEiJ_G0018132
protein coding gene Chr11:83095360-83100446 (+)
CBA/J MGP_CBAJ_G0018548
protein coding gene Chr11:89564836-89569902 (+)
DBA/2J MGP_DBA2J_G0018656
protein coding gene Chr11:79661829-79666943 (+)
FVB/NJ MGP_FVBNJ_G0018645
protein coding gene Chr11:79209416-79214476 (+)
LP/J MGP_LPJ_G0018726
protein coding gene Chr11:83826168-83831092 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018672
protein coding gene Chr11:89742760-89747818 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019255
protein coding gene Chr11:82762541-82767607 (+)
PWK/PhJ MGP_PWKPhJ_G0017902
protein coding gene Chr11:80488079-80493391 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017693
protein coding gene Chr11:82374848-82381535 (+)
WSB/EiJ MGP_WSBEiJ_G0018184
protein coding gene Chr11:82636653-82643293 (+)



Homology
more
  • Human Ortholog
    CCL11, C-C motif chemokine ligand 11
  • Vertebrate Orthologs
    6
  • Human Ortholog
    CCL11, C-C motif chemokine ligand 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SCYA11
  • Links
    NCBI Gene ID: 6356
    neXtProt AC: NX_P51671
    UniProt: P51671

  • Chr Location
    17q12; chr17:34285668-34288180 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human CCL11 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display decreased numbers of eosinophils and impaired eosinophil recruitment after antigen challenge. However, a different homozygous disruption does not result in eosinophil abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20292 NCBI Gene Model | MGI Sequence Detail 5124 C57BL/6J ±  kb
transcript NM_011330 RefSeq | MGI Sequence Detail 1073 C57BL/6  
polypeptide P48298 UniProt | EBI | MGI Sequence Detail 97 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    Genomic 2
    cDNA 18
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-24461
References
more
  • Summaries
    All 98
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 41
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:252859 Huang Z, et al., The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity. Cell Metab. 2017 Sep 5;26(3):493-508.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory