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Hsd11b1 Gene Detail
Summary
  • Symbol
    Hsd11b1
  • Name
    hydroxysteroid 11-beta dehydrogenase 1
  • Synonyms
    11beta-HSD-1, 11beta-hydroxysteroid dehydrogenase type 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103562
    NCBI Gene: 15483
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:193221634-193264075 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42442 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 97.67 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HSD11B1, hydroxysteroid 11-beta dehydrogenase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSD11B1, hydroxysteroid 11-beta dehydrogenase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    11-beta-HSD1, 11-DH, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1
  • Links
    NCBI Gene ID: 3290
    neXtProt AC: NX_P28845
    UniProt: P28845

  • Chr Location
    1q32.2; chr1:209686180-209734950 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Hsd11b1 mouse models; 1 with human HSD11B1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 7 alleles in 8 genetic backgrounds
    39 phenotypes from multigenic genotypes
    3 images
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display improved glucose tolerance and lower circulating lipid levels. Mice homozygous for a different targeted allele exhibit decreased susceptibility to weight gain, adiposis or hyperinsulinemia induced by 11-DHC.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030692 VEGA Gene Model | MGI Sequence Detail 42442 C57BL/6J ±  kb
    transcript OTTMUST00000075989 VEGA | MGI Sequence Detail 1623 Not Applicable  
    polypeptide OTTMUSP00000039928 VEGA | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      320 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      Genomic 1
      cDNA 114
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24447
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 14
      Diseases 4
      Gene Ontology 6
      Phenotypes 52
    • Earliest
      J:23036 Oppermann UC, et al., Cloning and primary structure of murine 11 beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase. Eur J Biochem. 1995 Jan 15;227(1-2):202-8
    • Latest
      J:256655 Verma M, et al., 11beta-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation. Brain Behav Immun. 2018 Mar;69:223-234

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory