Hsd11b1
Gene Detail

Symbol Name ID

Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 MGI:103562

Synonyms

11beta-HSD-1, 11beta-hydroxysteroid dehydrogenase type 1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

97.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:193221630-193264054 bp, - strand From VEGA annotation of GRCm38   42425 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

Gene Tree: Hsd11b1

Human homologs

Human Homolog		HSD11B1, hydroxysteroid (11-beta) dehydrogenase 1
NCBI Gene ID		3290
neXtProt AC		NX_P28845
Human Synonyms		11-beta-HSD1, 11-DH, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1
Human Chr (Location)		1q32-q41; chr1:209686180-209734950 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human HSD11B1

Alleles and phenotypes

All alleles(13) : Gene trapped(2) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruptions in this gene display improved glucose tolerance and lower circulating lipid levels. Mice homozygous for a different targeted allele exhibit decreased susceptibility to weight gain, adiposis or hyperinsulinemia induced by 11-DHC.

 
Human Diseases Modeled Using Mouse Hsd11b1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	glucocorticoid biosynthetic process, glucocorticoid catabolic process, ...
Component	apical part of cell, cytoplasm, ...
Function	11-beta-hydroxysteroid dehydrogenase (NADP+) activity, 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)

Data Summary: Results (96)    Tissues (95)    Images (14)
Theiler Stages: 11, 22

Assay Type	Results
RNA in situ	94
RT-PCR	2

cDNA source data(113)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(115) Genomic(1) cDNA(113) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000030692 (Evidence)
Ensembl Gene Model	ENSMUSG00000016194 (Evidence)
Entrez Gene	15483 (Evidence)
UniGene	28328
DFCI	TC1580265, TC1620051
DoTS	DT.87069375, DT.94188126, DT.99840605, DT.99840606
NIA Mouse Gene Index	U022221
EC	1.1.1.146
PDB	1Y5M, 1Y5R, 3GMD, 4NMH, 4K26
Consensus CDS Project	CCDS15635.1
International Mouse Knockout Project Status	Hsd11b1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030692	VEGA Gene Model | MGI Sequence Detail	42425	C57BL/6J
transcript	OTTMUST00000075988	VEGA | MGI Sequence Detail	1393	Not Applicable
polypeptide	OTTMUSP00000039927	VEGA | MGI Sequence Detail	292	Not Applicable

All sequences(64) RefSeq(8) UniProt(6)

Polymorphisms

SNPs within 2kb(323 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002347	Glucose/ribitol dehydrogenase
InterPro	IPR016040	NAD(P)-binding domain
InterPro	IPR020904	Short-chain dehydrogenase/reductase, conserved site
InterPro	IPR002198	Short-chain dehydrogenase/reductase SDR
Protein Ontology	PR:000008770	corticosteroid 11-beta-dehydrogenase isozyme 1

References

(Earliest) J:23036 Oppermann UC, et al., Cloning and primary structure of murine 11 beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase. Eur J Biochem. 1995 Jan 15;227(1-2):202-8
(Latest) J:207713 Harno E, et al., 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors still improve metabolic phenotype in male 11beta-HSD1 knockout mice suggesting off-target mechanisms. Endocrinology. 2013 Dec;154(12):4580-93
All references(92)

Other accession IDs

MGD-MRK-24447