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Hsd11b1 Gene Detail
Summary
  • Symbol
    Hsd11b1
  • Name
    hydroxysteroid 11-beta dehydrogenase 1
  • Synonyms
    11beta-HSD-1, 11beta-hydroxysteroid dehydrogenase type 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103562
    NCBI Gene: 15483
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:193221640-193264049 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 97.67 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103562
 protein coding gene Chr1:193221634-193264075 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016962
 protein coding gene Chr1:200311618-200360139 (-)
A/J MGP_AJ_G0016941
 protein coding gene Chr1:192071400-192117413 (-)
AKR/J MGP_AKRJ_G0016906
 protein coding gene Chr1:197796342-197851790 (-)
BALB/cJ MGP_BALBcJ_G0016899
 protein coding gene Chr1:192766050-192810585 (-)
C3H/HeJ MGP_C3HHeJ_G0016723
 protein coding gene Chr1:198640278-198687722 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017362
 protein coding gene Chr1:206675769-206699670 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015069
 protein coding gene Chr1:182946167-182993101 (-)
CAST/EiJ MGP_CASTEiJ_G0016306
 protein coding gene Chr1:198220292-198266991 (-)
CBA/J MGP_CBAJ_G0016697
 protein coding gene Chr1:214309812-214357676 (-)
DBA/2J MGP_DBA2J_G0016803
 protein coding gene Chr1:190789883-190833504 (-)
FVB/NJ MGP_FVBNJ_G0016799
 protein coding gene Chr1:188914732-188958297 (-)
LP/J MGP_LPJ_G0016878
 protein coding gene Chr1:201488520-201534014 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016831
 protein coding gene Chr1:220945912-220997219 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017399
 protein coding gene Chr1:197616984-197664913 (-)
PWK/PhJ MGP_PWKPhJ_G0016093
 protein coding gene Chr1:190112382-190158958 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015869
 protein coding gene Chr1:196649130-196694456 (-)
WSB/EiJ MGP_WSBEiJ_G0016368
 protein coding gene Chr1:197907351-197958776 (-)



Homology
more
  • Human Ortholog
    HSD11B1, hydroxysteroid 11-beta dehydrogenase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSD11B1, hydroxysteroid 11-beta dehydrogenase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    11-beta-HSD1, 11-DH, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1
  • Links
    NCBI Gene ID: 3290
    neXtProt AC: NX_P28845
    UniProt: P28845

  • Chr Location
    1q32.2; chr1:209686180-209734950 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Hsd11b1 mouse models; 1 with human HSD11B1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 7 alleles in 8 genetic backgrounds
    39 phenotypes from multigenic genotypes
    3 images
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display improved glucose tolerance and lower circulating lipid levels. Mice homozygous for a different targeted allele exhibit decreased susceptibility to weight gain, adiposis or hyperinsulinemia induced by 11-DHC.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    133
  • Tissues
    103
  • cDNA Data
    114
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15483 NCBI Gene Model | MGI Sequence Detail 42410 C57BL/6J ±  kb
    transcript NM_008288 RefSeq | MGI Sequence Detail 1381 C57BL/6  
    polypeptide P50172 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      Genomic 1
      cDNA 114
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24447
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 14
      Diseases 4
      Gene Ontology 7
      Phenotypes 57
    • Earliest
      J:23036 Oppermann UC, et al., Cloning and primary structure of murine 11 beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase. Eur J Biochem. 1995 Jan 15;227(1-2):202-8
    • Latest
      J:264080 Matsumoto A, et al., Attenuated Activation of Homeostatic Glucocorticoid in Keratinocytes Induces Alloknesis via Aberrant Artemin Production. J Invest Dermatol. 2018 Jul;138(7):1491-1500
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/26/2019
    MGI 6.14     		The Jackson Laboratory