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Hsd11b1
Gene Detail
 Symbol
Name
ID
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
MGI:103562
Synonyms 11beta-HSD-1, 11beta-hydroxysteroid dehydrogenase type 1
Feature Type protein coding gene
Genetic Map
Chromosome 1
97.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:193221630-193264054 bp, - strand
From VEGA annotation of GRCm38

  42425 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog

Gene Tree: Hsd11b1

Human
homologs
Human Homolog HSD11B1, hydroxysteroid (11-beta) dehydrogenase 1
NCBI Gene ID 3290
neXtProt AC  NX_P28845
Human Synonyms  11-beta-HSD1, 11-DH, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1
Human Chr (Location)  1q32-q41; chr1:209686180-209734950 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HSD11B1
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(2) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display improved glucose tolerance and lower circulating lipid levels. Mice homozygous for a different targeted allele exhibit decreased susceptibility to weight gain, adiposis or hyperinsulinemia induced by 11-DHC.
 
Human Diseases Modeled Using Mouse Hsd11b1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Hsd11b1 interacts with 65 markers (Mir19a, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process glucocorticoid biosynthetic process, glucocorticoid catabolic process, ...
Component apical part of cell, cytoplasm, ...
Function 11-beta-hydroxysteroid dehydrogenase (NADP+) activity, 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (96)    Tissues (95)    Images (14)
Theiler Stages: 11, 22
Assay TypeResults
RNA in situ 94
RT-PCR 2
cDNA source data(113)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(115) Genomic(1) cDNA(113) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000030692 (Evidence)
Ensembl Gene ModelENSMUSG00000016194 (Evidence)
Entrez Gene15483 (Evidence)
UniGene28328
DFCITC1580265, TC1620051
DoTSDT.87069375, DT.94188126, DT.99840605, DT.99840606
NIA Mouse Gene IndexU022221
EC1.1.1.146
PDB1Y5M, 1Y5R, 3GMD, 4NMH, 4K26
Consensus CDS ProjectCCDS15635.1
International Mouse Knockout Project StatusHsd11b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030692 VEGA Gene Model | MGI Sequence Detail 42425 C57BL/6J ±  kb
transcript OTTMUST00000075988 VEGA | MGI Sequence Detail 1393 Not Applicable 
polypeptide OTTMUSP00000039927 VEGA | MGI Sequence Detail 292 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(8) UniProt(6)
Polymorphisms SNPs within 2kb(323 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000008770 corticosteroid 11-beta-dehydrogenase isozyme 1
References (Earliest) J:23036 Oppermann UC, et al., Cloning and primary structure of murine 11 beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase. Eur J Biochem. 1995 Jan 15;227(1-2):202-8
(Latest) J:211636 Morgan SA, et al., 11beta-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):E2482-91
All references(95)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-24447

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory