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Hsd11b1
Gene Detail
Symbol

Name
ID
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
MGI:103562
Synonyms
11beta-HSD-1, 11beta-hydroxysteroid dehydrogenase type 1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
97.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:193221634-193264075 bp, - strand
From VEGA annotation of GRCm38

  42442 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog

HCOP human homology predictions: HSD11B1
Gene Tree: Hsd11b1

Human
homologs
HSD11B1, hydroxysteroid (11-beta) dehydrogenase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3290
neXtProt AC: NX_P28845

Human Synonyms: 11-beta-HSD1, 11-DH, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1

Human Chr (Location): 1q32-q41; chr1:209686180-209734950 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HSD11B1

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(2) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display improved glucose tolerance and lower circulating lipid levels. Mice homozygous for a different targeted allele exhibit decreased susceptibility to weight gain, adiposis or hyperinsulinemia induced by 11-DHC.
 
Human Diseases Modeled in Mice Using Hsd11b1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Hsd11b1 interacts with 65 markers (Mir19a, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (96)    Tissues (95)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 2
cDNA source data(113)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase hsd11b1    NEW 
Molecular
reagents
All nucleic(115) Genomic(1) cDNA(113) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000030692 (Evidence)
Ensembl Gene Model ENSMUSG00000016194 (Evidence)
Entrez Gene 15483 (Evidence)
UniGene 28328
DFCI TC1580265, TC1620051
DoTS DT.99840606, DT.99840605, DT.94188126, DT.87069375
NIA Mouse Gene Index U022221
EC 1.1.1.146
PDB 4NMH, 3GMD, 1Y5R, 1Y5M, 4K26
Consensus CDS Project CCDS15635.1
International Mouse Phenotyping Consortium Status Hsd11b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030692 VEGA Gene Model | MGI Sequence Detail 42442 C57BL/6J ±  kb
transcript OTTMUST00000075989 VEGA | MGI Sequence Detail 1623 Not Applicable 
polypeptide OTTMUSP00000039928 VEGA | MGI Sequence Detail 292 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(323 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000008770 corticosteroid 11-beta-dehydrogenase isozyme 1
References
(Earliest) J:23036 Oppermann UC, et al., Cloning and primary structure of murine 11 beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase. Eur J Biochem. 1995 Jan 15;227(1-2):202-8
(Latest) J:218322 Yau JL, et al., Intrahippocampal glucocorticoids generated by 11beta-HSD1 affect memory in aged mice. Neurobiol Aging. 2015 Jan;36(1):334-43
All references(97)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-24447

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory