Hsd11b1 MGI Mouse Gene Detail - MGI:103562 - hydroxysteroid 11-beta dehydrogenase 1

Hsd11b1 Gene Detail

Symbol

Hsd11b1
Name

hydroxysteroid 11-beta dehydrogenase 1
Synonyms

11beta-HSD-1, 11beta-hydroxysteroid dehydrogenase type 1

Feature Type

protein coding gene
IDs

MGI:103562
NCBI Gene: 15483

Sequence Map

Chr1:193221634-193264075 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

42442 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 97.67 cM
Mapping Data

3 experiments

Human Ortholog

HSD11B1, hydroxysteroid 11-beta dehydrogenase 1

Vertebrate Orthologs

10

Human Ortholog

HSD11B1, hydroxysteroid 11-beta dehydrogenase 1
Orthology source: HomoloGene, HGNC
Synonyms

11-beta-HSD1, 11-DH, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1
Links

HGNC:5208

NCBI Gene ID: 3290

neXtProt AC: NX_P28845

UniProt: P28845
Chr Location

1q32.2; chr1:209686180-209734950 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 68471
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: HSD11B1
Gene Tree

Hsd11b1

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

43 phenotypes from 7 alleles in 8 genetic backgrounds
39 phenotypes from multigenic genotypes
3 images
49 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Gene trapped

2
Targeted

12
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available

Mice homozygous for disruptions in this gene display improved glucose tolerance and lower circulating lipid levels. Mice homozygous for a different targeted allele exhibit decreased susceptibility to weight gain, adiposis or hyperinsulinemia induced by 11-DHC.

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All GO Annotations

23
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

126
Tissues

98
cDNA Data

113
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hsd11b1

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Hsd11b1 interacts with 65 markers (Mir19a, Mir26a-1, Mir26a-2, ...) View All

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All Sequences

56
RefSeq

8
UniProt

5
CCDS

CCDS15635.1
UniGene

28328

			Length	Strain/Species	Flank
genomic	OTTMUSG00000030692	VEGA Gene Model \| MGI Sequence Detail	42442	C57BL/6J	± kb
transcript	OTTMUST00000075989	VEGA \| MGI Sequence Detail	1623	Not Applicable
polypeptide	OTTMUSP00000039928	VEGA \| MGI Sequence Detail	292	Not Applicable

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SNPs within 2kb

320 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000008770 corticosteroid 11-beta-dehydrogenase isozyme 1

(term hierarchy)
PDB

1Y5M, 1Y5R, 3GMD, 4K26, 4NMH
EC

1.1.1.146
InterPro Domains

IPR016040 NAD(P)-binding domain

IPR020904 Short-chain dehydrogenase/reductase, conserved site

IPR002347 Short-chain dehydrogenase/reductase SDR

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All nucleic 116

Genomic 1

cDNA 113

Primer pair 2

Microarray probesets 3

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MGD-MRK-24447

Summaries

All 104

Developmental Gene Expression 13

Diseases 1

Gene Ontology 7

Phenotypes 49
Earliest

J:23036 Oppermann UC, et al., Cloning and primary structure of murine 11 beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase. Eur J Biochem. 1995 Jan 15;227(1-2):202-8
Latest

J:240133 Larner DP, et al., Male 11beta-HSD1 Knockout Mice Fed Trans-Fats and Fructose Are Not Protected From Metabolic Syndrome or Nonalcoholic Fatty Liver Disease. Endocrinology. 2016 Sep;157(9):3493-504

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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