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Tiam1 Gene Detail
Summary
  • Symbol
    Tiam1
  • Name
    T cell lymphoma invasion and metastasis 1
  • Synonyms
    D16Ium10, D16Ium10e
  • Feature Type
    protein coding gene
  • IDs
    MGI:103306
    NCBI Gene: 21844
Location & Maps
more
  • Sequence Map
    Chr16:89787111-89980080 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      192970 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 51.50 cM, cytoband C3-4
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    TIAM1, T-cell lymphoma invasion and metastasis 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TIAM1, T-cell lymphoma invasion and metastasis 1
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 7074
    neXtProt AC: NX_Q13009

  • Chr Location
    21q22.11; chr21:31118418-31559977 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2443
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: TIAM1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Gene trapped
    16
  • Targeted
    9
  • Genomic Mutations
    6 involving Tiam1
  • Incidental Mutations
Mice homozygous for a targeted null allele display resistance to chemically-induced tumors, however, tumors that do develop progress to malignancy. Mice homozygous for a gene trap allele display anencephaly, exencephaly and/or neural tube defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024287 VEGA Gene Model | MGI Sequence Detail 192970 C57BL/6J ±  kb
transcript OTTMUST00000059479 VEGA | MGI Sequence Detail 7406 Not Applicable  
polypeptide OTTMUSP00000028932 VEGA | MGI Sequence Detail 1591 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2190 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000016328 T-lymphoma invasion and metastasis-inducing protein 1
  • PDB
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
    IPR001478 PDZ domain
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR003116 Raf-like Ras-binding
    IPR033360 T-lymphoma invasion and metastasis-inducing protein 1
Molecular
Reagents
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  • All nucleic 79
    Genomic 4
    cDNA 74
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-24190, MGD-MRK-33864, MGI:106177, MGI:2146497
References
more
  • Summaries
    All 78
    Developmental Gene Expression 14
    Gene Ontology 10
    Phenotypes 24
  • Earliest
    J:18555 Habets GG, et al., Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell. 1994 May 20;77(4):537-49
  • Latest
    J:222968 Ma HL, et al., Inhibition of Endometrial Tiam1/Rac1 Signals Induced by miR-22 Up-Regulation Leads to the Failure of Embryo Implantation During the Implantation Window in Pregnant Mice. Biol Reprod. 2015 Jun;92(6):152

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory