Rbl1
Gene Detail

Symbol Name ID

Rbl1 retinoblastoma-like 1 (p107) MGI:103300

Synonyms

p107

Feature Type

protein coding gene

Genetic Map

Chromosome 2

78.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:157145893-157204534 bp, - strand From VEGA annotation of GRCm38   58642 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2172  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: retinoblastoma-like protein
Gene Tree: Rbl1

Human homologs

Human Homolog		RBL1, retinoblastoma-like 1 (p107)
NCBI Gene ID		5933
neXtProt AC		NX_P28749
Human Synonyms		CP107, p107, PRB1
Human Chr (Location)		20q11.2; chr20:35626178-35724410 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(19) : Targeted(7) Gene trapped(12)
 

Homozygotes for targeted null mutations are viable and fertile, but may show impaired growth, myeloid hyperplasia in spleen and liver and give rise to cells with a 2X doubling time in vitro. These effects are genetic background dependent.

 
Human Diseases Modeled Using Mouse Rbl1 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cell cycle, chromatin modification, ...
Component	nucleus, transcription factor complex
Function	protein binding, transcription factor binding

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (97)    Tissues (53)    Images (5)
Theiler Stages: 17, 19, 20, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	27
Northern blot	57
Western blot	7

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) cDNA(28) Primer pair(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000016175 (Evidence)
Ensembl Gene Model	ENSMUSG00000027641 (Evidence)
Entrez Gene	19650 (Evidence)
DFCI	TC1575637, TC1589373, TC1720289
NIA Mouse Gene Index	U023576
Consensus CDS Project	CCDS16974.1
International Mouse Knockout Project Status	Rbl1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016175	VEGA Gene Model | MGI Sequence Detail	58642	C57BL/6J
transcript	OTTMUST00000038712	VEGA | MGI Sequence Detail	4862	Not Applicable
polypeptide	OTTMUSP00000017311	VEGA | MGI Sequence Detail	1063	Not Applicable

All sequences(42) RefSeq(4) UniProt(5)

Polymorphisms

All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs(265 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013763	Cyclin-like
InterPro	IPR024599	Domain of unknown function DUF3452, retinoblastoma-associated
InterPro	IPR015030	Rb C-terminal
InterPro	IPR002720	Retinoblastoma-associated protein, A-box
InterPro	IPR002719	Retinoblastoma-associated protein, B-box
Protein Ontology	PR:000000118	retinoblastoma-like protein 1

References

(Earliest) J:18604 Schneider JW, et al., Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science. 1994 Jun 3;264(5164):1467-71
(Latest) J:193515 Nittner D, et al., Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation. Nat Cell Biol. 2012 Sep;14(9):958-65
All references(118)

Other accession IDs

MGD-MRK-24184, MGI:2139378