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Rbl1 Gene Detail
Summary
  • Symbol
    Rbl1
  • Name
    RB transcriptional corepressor like 1
  • Synonyms
    p107, retinoblastoma-like 1 (p107)
  • Feature Type
    protein coding gene
  • IDs
    MGI:103300
    NCBI Gene: 19650
  • Gene Overview
    MyGene.info: RBL1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:157145893-157204534 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 78.05 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    442 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103300
protein coding gene Chr2:157145893-157204534 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026777
protein coding gene Chr2:162128018-162186927 (-)
A/J MGP_AJ_G0026743
protein coding gene Chr2:155645628-155707977 (-)
AKR/J MGP_AKRJ_G0026714
protein coding gene Chr2:160222088-160285826 (-)
BALB/cJ MGP_BALBcJ_G0026752
protein coding gene Chr2:155931292-155995401 (-)
C3H/HeJ MGP_C3HHeJ_G0026494
protein coding gene Chr2:160522305-160588286 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027201
protein coding gene Chr2:166920428-166986506 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024571
protein coding gene Chr2:149109117-149164820 (-)
CAST/EiJ MGP_CASTEiJ_G0025956
protein coding gene Chr2:160875607-160937268 (-)
CBA/J MGP_CBAJ_G0026471
protein coding gene Chr2:172954525-173020186 (-)
DBA/2J MGP_DBA2J_G0026609
protein coding gene Chr2:154817146-154877980 (-)
FVB/NJ MGP_FVBNJ_G0026576
protein coding gene Chr2:153216856-153277449 (-)
LP/J MGP_LPJ_G0026714
protein coding gene Chr2:162221062-162291284 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026597
protein coding gene Chr2:176798599-176879510 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027257
protein coding gene Chr2:160038822-160101819 (-)
PWK/PhJ MGP_PWKPhJ_G0025690
protein coding gene Chr2:154328819-154399141 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025493
protein coding gene Chr2:158990428-159052756 (-)
WSB/EiJ MGP_WSBEiJ_G0026026
protein coding gene Chr2:160928793-160992989 (-)



Homology
more
  • Human Ortholog
    RBL1, RB transcriptional corepressor like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RBL1, RB transcriptional corepressor like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CP107, p107, PRB1
  • Links
    NCBI Gene ID: 5933
    neXtProt AC: NX_P28749
    UniProt: P28749

  • Chr Location
    20q11.23; chr20:36996349-37096215 (-)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 5 alleles in 10 genetic backgrounds
    105 phenotypes from multigenic genotypes
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations are viable and fertile, but may show impaired growth, myeloid hyperplasia in spleen and liver and give rise to cells with a 2X doubling time in vitro. These effects are genetic background dependent.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19650 NCBI Gene Model | MGI Sequence Detail 58642 C57BL/6J ±  kb
    transcript NM_011249 RefSeq | MGI Sequence Detail 4909 C57BL/6  
    polypeptide Q64701 UniProt | EBI | MGI Sequence Detail 1063 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 1
      cDNA 28
      Primer pair 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-24184, MGI:2139378
    References
    more
    • Summaries
      All 167
      Developmental Gene Expression 34
      Diseases 3
      Gene Ontology 12
      Phenotypes 86
    • Earliest
      J:18604 Schneider JW, et al., Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science. 1994 Jun 3;264(5164):1467-71
    • Latest
      J:263656 Oshikawa M, et al., Dnmt1-dependent Chk1 pathway suppression is protective against neuron division. Development. 2017 Sep 15;144(18):3303-3314

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory