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Rbl1
Gene Detail
Symbol

Name
ID
Rbl1
retinoblastoma-like 1 (p107)
MGI:103300
Synonyms
p107
Feature Type
protein coding gene
Genetic Map
Chromosome 2
78.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:157145893-157204534 bp, - strand
From VEGA annotation of GRCm38

  58642 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2172  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: retinoblastoma-like protein
Gene Tree: Rbl1

Human
homologs
Human Homolog RBL1, retinoblastoma-like 1
NCBI Gene ID 5933
neXtProt AC  NX_P28749
Human Synonyms  CP107, p107, PRB1
Human Chr (Location)  20q11.2; chr20:36996349-37096000 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(12) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations are viable and fertile, but may show impaired growth, myeloid hyperplasia in spleen and liver and give rise to cells with a 2X doubling time in vitro. These effects are genetic background dependent.
 
Human Diseases Modeled Using Mouse Rbl1 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Rbl1 interacts with 298 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell cycle, chromatin modification, ...
Component nucleus, transcription factor complex
Function protein binding, transcription factor binding
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (99)    Tissues (63)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 27
Northern blot 57
Western blot 7
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(28) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016175 (Evidence)
Ensembl Gene ModelENSMUSG00000027641 (Evidence)
Entrez Gene19650 (Evidence)
DFCITC1720289, TC1589373, TC1575637
NIA Mouse Gene IndexU023576
Consensus CDS ProjectCCDS16974.1
International Mouse Knockout Project StatusRbl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016175 VEGA Gene Model | MGI Sequence Detail 58642 C57BL/6J ±  kb
transcript OTTMUST00000038712 VEGA | MGI Sequence Detail 4862 Not Applicable 
polypeptide OTTMUSP00000017311 VEGA | MGI Sequence Detail 1063 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(6) UniProt(9)
Polymorphisms
All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(452 from dbSNP Build 137)    SNPs within 2kb including multiple locations(470)
Protein-related
information
ResourceIDDescription
InterPro IPR013763 Cyclin-like
InterPro IPR024599 Domain of unknown function DUF3452, retinoblastoma-associated
InterPro IPR015030 Rb C-terminal
InterPro IPR002720 Retinoblastoma-associated protein, A-box
InterPro IPR002719 Retinoblastoma-associated protein, B-box
Protein Ontology PR:000000118 retinoblastoma-like protein 1
References
(Earliest) J:18604 Schneider JW, et al., Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science. 1994 Jun 3;264(5164):1467-71
(Latest) J:212743 Park JW, et al., High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins. Oncogene. 2014 Jun 26;33(26):3383-91
All references(128)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-24184, MGI:2139378

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory