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Rbl1 Gene Detail
Summary
  • Symbol
    Rbl1
  • Name
    retinoblastoma-like 1 (p107)
  • Synonyms
    p107
  • Feature Type
    protein coding gene
  • IDs
    MGI:103300
    NCBI Gene: 19650
  • Gene Overview
    MyGene.info: RBL1
Location & Maps
more
  • Sequence Map
    Chr2:157145893-157204534 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58642 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 78.05 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    RBL1, RB transcriptional corepressor like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RBL1, RB transcriptional corepressor like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CP107, p107, PRB1
  • Links
    NCBI Gene ID: 5933
    neXtProt AC: NX_P28749

  • Chr Location
    20q11.2; chr20:36996349-37096000 (-)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 6 alleles in 11 genetic backgrounds
    104 phenotypes from multigenic genotypes
    78 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations are viable and fertile, but may show impaired growth, myeloid hyperplasia in spleen and liver and give rise to cells with a 2X doubling time in vitro. These effects are genetic background dependent.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016175 VEGA Gene Model | MGI Sequence Detail 58642 C57BL/6J ±  kb
transcript OTTMUST00000038712 VEGA | MGI Sequence Detail 4862 Not Applicable  
polypeptide OTTMUSP00000017311 VEGA | MGI Sequence Detail 1063 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    442 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000000118 retinoblastoma-like protein 1
  • InterPro Domains
    IPR013763 Cyclin-like
    IPR002720 Retinoblastoma-associated protein, A-box
    IPR002719 Retinoblastoma-associated protein, B-box
    IPR015030 Retinoblastoma-associated protein, C-terminal
    IPR024599 Retinoblastoma-associated protein, N-terminal
    IPR028310 Retinoblastoma-like protein 1
    IPR028309 Retinoblastoma protein family
Molecular
Reagents
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  • All nucleic 30
    cDNA 28
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-24184, MGI:2139378
References
more
  • Summaries
    All 139
    Developmental Gene Expression 31
    Diseases 3
    Gene Ontology 9
    Phenotypes 78
  • Earliest
    J:18604 Schneider JW, et al., Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science. 1994 Jun 3;264(5164):1467-71
  • Latest
    J:228312 Tarangelo A, et al., Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. Nat Commun. 2015;6:10028

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory