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Relb Gene Detail
Summary
  • Symbol
    Relb
  • Name
    avian reticuloendotheliosis viral (v-rel) oncogene related B
  • Synonyms
    shep
  • Feature Type
    protein coding gene
  • IDs
    MGI:103289
    NCBI Gene: 19698
  • Gene Overview
    MyGene.info: RELB
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19606217-19629438 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103289
protein coding gene Chr7:19606217-19629438 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031787
protein coding gene Chr7:17638627-17661808 (-)
A/J MGP_AJ_G0031763
protein coding gene Chr7:17255594-17278735 (-)
AKR/J MGP_AKRJ_G0031689
protein coding gene Chr7:17735395-17758482 (-)
BALB/cJ MGP_BALBcJ_G0031768
protein coding gene Chr7:17461588-17485465 (-)
C3H/HeJ MGP_C3HHeJ_G0031490
protein coding gene Chr7:17997718-18021930 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032234
protein coding gene Chr7:18504707-18532383 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029300
protein coding gene Chr7:18901902-18926548 (-)
CAST/EiJ MGP_CASTEiJ_G0030824
protein coding gene Chr7:14216699-14454829 (-)
CBA/J MGP_CBAJ_G0031452
protein coding gene Chr7:19179181-19208420 (-)
DBA/2J MGP_DBA2J_G0031607
protein coding gene Chr7:17206171-17229858 (-)
FVB/NJ MGP_FVBNJ_G0031559
protein coding gene Chr7:17069942-17095290 (-)
LP/J MGP_LPJ_G0031690
protein coding gene Chr7:17955494-17978556 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031595
protein coding gene Chr7:19010478-19036952 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032262
protein coding gene Chr7:17340870-17365075 (-)
PWK/PhJ MGP_PWKPhJ_G0030557
protein coding gene Chr7:14302731-14326789 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030384
protein coding gene Chr7:12045912-12076921 (-)
WSB/EiJ MGP_WSBEiJ_G0030933
protein coding gene Chr7:17561198-17585463 (-)



Homology
more
  • Human Ortholog
    RELB, RELB proto-oncogene, NF-kB subunit
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RELB, RELB proto-oncogene, NF-kB subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IMD53, IREL, I-REL, REL-B
  • Links
    NCBI Gene ID: 5971
    neXtProt AC: NX_Q01201
    UniProt: Q01201

  • Chr Location
    19q13.32; chr19:45001449-45038198 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Relb mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    110 phenotypes from 4 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    3 images
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant homozygotes die prematurely with phenotypes including inflammatory cell infiltration of organs, myeloid hyperplasia, splenomegaly, reduction in thymic dendritic cells, impaired cellular immunity, hyperkeratosis, epidermal hyperplasia, or hepatitiswith mononuclear infiltration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19698 NCBI Gene Model | MGI Sequence Detail 23222 C57BL/6J ±  kb
    transcript NM_009046 RefSeq | MGI Sequence Detail 2218 FVB/N  
    polypeptide Q04863 UniProt | EBI | MGI Sequence Detail 558 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 3
      cDNA 40
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24171, MGI:4838325
    References
    more
    • Summaries
      All 160
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 18
      Phenotypes 73
    • Earliest
      J:22332 Ryseck RP, et al., RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B. Mol Cell Biol. 1992 Feb;12(2):674-84
    • Latest
      J:264370 Sima J, et al., Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8173-8178

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory