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Relb Gene Detail
Summary
  • Symbol
    Relb
  • Name
    avian reticuloendotheliosis viral (v-rel) oncogene related B
  • Synonyms
    shep
  • Feature Type
    protein coding gene
  • IDs
    MGI:103289
    NCBI Gene: 19698
Location & Maps
more
  • Sequence Map
    Chr7:19606217-19629438 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23222 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RELB, v-rel avian reticuloendotheliosis viral oncogene homolog B
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RELB, v-rel avian reticuloendotheliosis viral oncogene homolog B
    Orthology source: HomoloGene
  • Synonyms
    IREL, I-REL, REL-B
  • Links
    NCBI Gene ID: 5971
    neXtProt AC: NX_Q01201

  • Chr Location
    19q13.32; chr19:45001449-45038198 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Relb mouse models

Human Disease Mouse Models
       Dermatitis, Atopic   OMIM: 603165 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    110 phenotypes from 4 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    3 images
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Gene trapped
    16
  • Spontaneous
    1
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
Mutant homozygotes die prematurely with phenotypes including inflammatory cell infiltration of organs, myeloid hyperplasia, splenomegaly, reduction in thymic dendritic cells, impaired cellular immunity, hyperkeratosis, epidermal hyperplasia, or hepatitiswith mononuclear infiltration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020490 VEGA Gene Model | MGI Sequence Detail 23222 C57BL/6J ±  kb
transcript OTTMUST00000048593 VEGA | MGI Sequence Detail 2209 Not Applicable  
polypeptide OTTMUSP00000022318 VEGA | MGI Sequence Detail 558 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    149 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    Genomic 3
    cDNA 39
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-24171, MGI:4838325
References
more
  • Summaries
    All 137
    Developmental Gene Expression 17
    Diseases 3
    Gene Ontology 16
    Phenotypes 67
  • Earliest
    J:22332 Ryseck RP, et al., RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B. Mol Cell Biol. 1992 Feb;12(2):674-84
  • Latest
    J:226752 Kondylis V, et al., NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis. Cancer Cell. 2015 Nov 9;28(5):582-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory