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Relb
Gene Detail
Symbol

Name
ID
Relb
avian reticuloendotheliosis viral (v-rel) oncogene related B
MGI:103289
Synonyms
shep
Feature Type
protein coding gene
Genetic Map
Chromosome 7
9.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:19606217-19629438 bp, - strand
From VEGA annotation of GRCm38

  23222 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4747  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: RELB
Protein SuperFamily: rel-related protein
Gene Tree: Relb

Human
homologs
RELB, v-rel avian reticuloendotheliosis viral oncogene homolog B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5971
neXtProt AC: NX_Q01201

Human Synonyms: IREL, I-REL, REL-B

Human Chr (Location): 19q13.32; chr19:45001449-45038198 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(16) Spontaneous(1) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant homozygotes die prematurely with phenotypes including inflammatory cell infiltration of organs, myeloid hyperplasia, splenomegaly, reduction in thymic dendritic cells, impaired cellular immunity, hyperkeratosis, epidermal hyperplasia, or hepatitis with mononuclear infiltration.
 
Human Diseases Modeled in Mice Using Relb (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Relb interacts with 52 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process antigen processing and presentation, cellular response to osmotic stress, ...
Component cytoplasm, cytoskeleton, ...
Function chromatin binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (37)    Tissues (33)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 37
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase relb    NEW 
Molecular
reagents
All nucleic(43) Genomic(3) cDNA(39) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000020490 (Evidence)
Ensembl Gene Model ENSMUSG00000002983 (Evidence)
Entrez Gene 19698 (Evidence)
UniGene 1741
DFCI TC1581637, TC1594956, TC1748424
DoTS DT.111008344, DT.40158829, DT.489281, DT.97341375
NIA Mouse Gene Index U028231
PDB 1ZK9, 1ZKA, 2V2T, 3DO7, 3JSS, 3JUZ, 3JV0, 3JV4, 3JV6, 4JGM, 4JHB
Consensus CDS Project CCDS39799.1, CCDS71896.1
International Mouse Phenotyping Consortium Status Relb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020490 VEGA Gene Model | MGI Sequence Detail 23222 C57BL/6J ±  kb
transcript OTTMUST00000048593 VEGA | MGI Sequence Detail 2209 Not Applicable 
polypeptide OTTMUSP00000022318 VEGA | MGI Sequence Detail 558 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(14) UniProt(7)
Polymorphisms
SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000451 NF-kappa-B/Rel/Dorsal
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000013876 transcription factor RelB
References
(Earliest) J:22332 Ryseck RP, et al., RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B. Mol Cell Biol. 1992 Feb;12(2):674-84
(Latest) J:222308 Fairfield H, et al., Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Genome Res. 2015 Jul;25(7):948-57
All references(139)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-24171, MGI:4838325

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory