About   Help   FAQ
Relb
Gene Detail
 Symbol
Name
ID
Relb
avian reticuloendotheliosis viral (v-rel) oncogene related B
MGI:103289
Synonyms shep
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:19606217-19629438 bp, - strand
From VEGA annotation of GRCm38

  23222 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4747  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: rel-related protein
Gene Tree: Relb

Human
homologs
Human Homolog RELB, v-rel avian reticuloendotheliosis viral oncogene homolog B
NCBI Gene ID 5971
neXtProt AC  NX_Q01201
Human Synonyms  IREL, I-REL, REL-B
Human Chr (Location)  19q13.32; chr19:45001449-45038198 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(16) Spontaneous(1) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant homozygotes die prematurely with phenotypes including inflammatory cell infiltration of organs, myeloid hyperplasia, splenomegaly, reduction in thymic dendritic cells, impaired cellular immunity, hyperkeratosis, epidermal hyperplasia, or hepatitis with mononuclear infiltration.
 
Human Diseases Modeled Using Mouse Relb (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Relb interacts with 52 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process antigen processing and presentation, cellular response to osmotic stress, ...
Component cytoplasm, cytoskeleton, ...
Function core promoter binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (37)    Tissues (33)    Images (9)
Theiler Stages: 15, 16, 17, 19, 21, 23
Assay TypeResults
RNA in situ 37
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(3) cDNA(39) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000020490 (Evidence)
Ensembl Gene ModelENSMUSG00000002983 (Evidence)
Entrez Gene19698 (Evidence)
UniGene1741
DFCITC1581637, TC1594956, TC1748424
DoTSDT.111008344, DT.40158829, DT.489281, DT.97341375
NIA Mouse Gene IndexU028231
PDB1ZKA, 2V2T, 3JSS, 3JUZ, 4JGM, 4JHB, 1ZK9, 3DO7, 3JV0, 3JV4, 3JV6
Consensus CDS ProjectCCDS39799.1, CCDS71896.1
International Mouse Knockout Project StatusRelb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020490 VEGA Gene Model | MGI Sequence Detail 23222 C57BL/6J ±  kb
transcript OTTMUST00000048593 VEGA | MGI Sequence Detail 2209 Not Applicable 
polypeptide OTTMUSP00000022318 VEGA | MGI Sequence Detail 558 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(6) UniProt(7)
Polymorphisms SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000451 NF-kappa-B/Rel/Dorsal
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000013876 transcription factor RelB
References (Earliest) J:22332 Ryseck RP, et al., RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B. Mol Cell Biol. 1992 Feb;12(2):674-84
(Latest) J:209992 Jin J, et al., Noncanonical NF-kappaB pathway controls the production of type I interferons in antiviral innate immunity. Immunity. 2014 Mar 20;40(3):342-54
All references(134)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-24171, MGI:4838325

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/16/2014
MGI 5.19
The Jackson Laboratory