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Yap1 Gene Detail
Summary
  • Symbol
    Yap1
  • Name
    yes-associated protein 1
  • Synonyms
    Yap, Yki, yorkie
  • Feature Type
    protein coding gene
  • IDs
    MGI:103262
    NCBI Gene: 22601
  • Gene Overview
    MyGene.info: YAP1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:7931999-8004596 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103262
protein coding gene Chr9:7931999-8004596 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034331
protein coding gene Chr9:4808131-4899209 (-)
A/J MGP_AJ_G0034309
protein coding gene Chr9:4916435-4990278 (-)
AKR/J MGP_AKRJ_G0034237
protein coding gene Chr9:4784660-4863767 (-)
BALB/cJ MGP_BALBcJ_G0034303
protein coding gene Chr9:4646362-4725577 (-)
C3H/HeJ MGP_C3HHeJ_G0034014
protein coding gene Chr9:4961444-5041039 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034825
protein coding gene Chr9:4982387-5064884 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031763
protein coding gene Chr9:4148970-4222765 (-)
CAST/EiJ MGP_CASTEiJ_G0033342
protein coding gene Chr9:4987473-5062756 (-)
CBA/J MGP_CBAJ_G0033987
protein coding gene Chr9:5146299-5240695 (-)
DBA/2J MGP_DBA2J_G0034144
protein coding gene Chr9:4774394-4859344 (-)
FVB/NJ MGP_FVBNJ_G0034089
protein coding gene Chr9:4557731-4630890 (-)
LP/J MGP_LPJ_G0034230
protein coding gene Chr9:4853395-4928172 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034133
protein coding gene Chr9:5853465-5936876 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034844
protein coding gene Chr9:4779698-4861675 (-)
PWK/PhJ MGP_PWKPhJ_G0033045
protein coding gene Chr9:4899821-4978365 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032883
protein coding gene Chr9:5027179-5099557 (-)
WSB/EiJ MGP_WSBEiJ_G0033457
protein coding gene Chr9:4810366-4887607 (-)



Homology
more
  • Human Ortholog
    YAP1, Yes associated protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    YAP1, Yes associated protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COB1, YAP, YAP2, YAP65, YKI
  • Links
    NCBI Gene ID: 10413
    neXtProt AC: NX_P46937
    UniProt: P46937

  • Chr Location
    11q22.1; chr11:102109957-102233423 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4452
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: YAP1
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    82 phenotypes from 9 alleles in 9 genetic backgrounds
    54 phenotypes from multigenic genotypes
    12 images
    115 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a null mutation of this gene die between embryonic days E9.5 and E10.5 due to yolk sac avasculogenesis and failure of attachment between the allantois and the chorion. Heterozygous mice are viable, appear normal and are fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22601 NCBI Gene Model | MGI Sequence Detail 72598 C57BL/6J ±  kb
    transcript NM_001171147 RefSeq | MGI Sequence Detail 4200 C57BL/6  
    polypeptide P46938 UniProt | EBI | MGI Sequence Detail 488 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 16
      Primer pair 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24140, MGI:2143022
    References
    more
    • Summaries
      All 251
      Developmental Gene Expression 94
      Diseases 1
      Gene Ontology 33
      Phenotypes 115
    • Earliest
      J:26090 Sudol M, et al., Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem. 1995 Jun 16;270(24):14733-41
    • Latest
      J:266255 Scavuzzo MA, et al., Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis. Nat Commun. 2018 Aug 22;9(1):3356

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory