Yap1
Gene Detail

Symbol Name ID

Yap1 yes-associated protein 1 MGI:103262

Synonyms

Yap, Yki, yorkie

Feature Type

protein coding gene

Genetic Map

Chromosome 9

2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:7931999-8004596 bp, - strand From VEGA annotation of GRCm38   72598 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4452  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Yap1

Human homologs

Human Homolog		YAP1, Yes-associated protein 1
NCBI Gene ID		10413
neXtProt AC		NX_P46937
Human Synonyms		YAP, YAP2, YAP65, YKI
Human Chr (Location)		11q13; chr11:101981192-102104154 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(39) : Targeted(8) Gene trapped(31)
 

Embryos homozygous for a null mutation of this gene die between embryonic days E9.5 and E10.5 due to yolk sac avasculogenesis and failure of attachment between the allantois and the chorion. Heterozygous mice are viable, appear normal and are fertile.

 

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	cell proliferation, cellular response to gamma radiation, ...
Component	cytoplasm, nucleus, ...
Function	chromatin binding, proline-rich region binding, ...

External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (14)    Tissues (9)    Images (17)
Theiler Stages: 19, 20, 21, 22, 24, 26, 28

Assay Type	Results
Immunohistochemistry	12
RT-PCR	2

cDNA source data(159)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(161) cDNA(160) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000038037 (Evidence)
Ensembl Gene Model	ENSMUSG00000053110 (Evidence)
Entrez Gene	22601 (Evidence)
UniGene	221992
DFCI	TC1573055, TC1590080, TC1755918
DoTS	DT.101737261, DT.494677, DT.91465455
NIA Mouse Gene Index	U030450
PDB	3JUA
Consensus CDS Project	CCDS40533.1, CCDS52718.1
International Mouse Knockout Project Status	Yap1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000038037	VEGA Gene Model | MGI Sequence Detail	72598	C57BL/6J
transcript	OTTMUST00000097973	VEGA | MGI Sequence Detail	4171	Not Applicable
polypeptide	OTTMUSP00000054974	VEGA | MGI Sequence Detail	488	Not Applicable

All sequences(70) RefSeq(4) UniProt(7)

Polymorphisms

SNPs(305 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001202	WW domain
Protein Ontology	PR:000017522	yorkie homolog

References

(Earliest) J:26090 Sudol M, et al., Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem. 1995 Jun 16;270(24):14733-41
(Latest) J:194212 Barry ER, et al., Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature. 2013 Jan 3;493(7430):106-10
All references(78)

Other accession IDs

MGD-MRK-24140, MGI:2143022