About   Help   FAQ
Yap1
Gene Detail
Symbol

Name
ID
Yap1
yes-associated protein 1
MGI:103262
Synonyms
Yap, Yki, yorkie
Feature Type
protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:7931999-8004596 bp, - strand
From VEGA annotation of GRCm38

  72598 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4452  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: YAP1
Gene Tree: Yap1

Human
homologs
YAP1, Yes-associated protein 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10413
neXtProt AC: NX_P46937

Human Synonyms: COB1, YAP, YAP2, YAP65, YKI

Human Chr (Location): 11q13; chr11:102110254-102233423 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human YAP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(31) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a null mutation of this gene die between embryonic days E9.5 and E10.5 due to yolk sac avasculogenesis and failure of attachment between the allantois and the chorion. Heterozygous mice are viable, appear normal and are fertile.
 
Phenotype Images(12)
Interactions
Yap1 interacts with 266 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process bud elongation involved in lung branching, cell morphogenesis, ...
Component cell junction, cytoplasm, ...
Function chromatin binding, proline-rich region binding, ...
External Resources: FuncBase
Expression
Literature Summary: (43 records)
Data Summary: Results (16)    Tissues (12)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 2
RT-PCR 2
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase yap1 ; ZFIN yap1    NEW 
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000038037 (Evidence)
Ensembl Gene Model ENSMUSG00000053110 (Evidence)
Entrez Gene 22601 (Evidence)
DFCI TC1755918, TC1590080, TC1573055
DoTS DT.91465455, DT.494677, DT.101737261
NIA Mouse Gene Index U030450
PDB 3JUA
Consensus CDS Project CCDS40533.1, CCDS52718.1
International Mouse Phenotyping Consortium Status Yap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038037 VEGA Gene Model | MGI Sequence Detail 72598 C57BL/6J ±  kb
transcript OTTMUST00000097973 VEGA | MGI Sequence Detail 4171 Not Applicable 
polypeptide OTTMUSP00000054974 VEGA | MGI Sequence Detail 488 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(16) UniProt(7)
Polymorphisms
SNPs within 2kb(332 from dbSNP Build 137)    SNPs within 2kb including multiple locations(334)
Protein-related
information
ResourceIDDescription
InterPro IPR001202 WW domain
Protein Ontology PR:000017522 yorkie homolog
References
(Earliest) J:26090 Sudol M, et al., Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem. 1995 Jun 16;270(24):14733-41
(Latest) J:219844 Taniguchi K, et al., A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 5;519(7541):57-62
All references(111)
Other
accession IDs
MGD-MRK-24140, MGI:2143022

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory