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Yap1
Gene Detail
 Symbol
Name
ID
Yap1
yes-associated protein 1
MGI:103262
Synonyms Yap, Yki, yorkie
Feature Type protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:7931999-8004596 bp, - strand
From VEGA annotation of GRCm38

  72598 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4452  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Yap1

Human
homologs
Human Homolog YAP1, Yes-associated protein 1
NCBI Gene ID 10413
neXtProt AC  NX_P46937
Human Synonyms  COB1, YAP, YAP2, YAP65, YKI
Human Chr (Location)  11q13; chr11:102110420-102233423 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human YAP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(31) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a null mutation of this gene die between embryonic days E9.5 and E10.5 due to yolk sac avasculogenesis and failure of attachment between the allantois and the chorion. Heterozygous mice are viable, appear normal and are fertile.
 
Phenotype Images(7)
Interactions
Yap1 interacts with 266 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process cell proliferation, cellular response to DNA damage stimulus, ...
Component cytoplasm, cytosol, ...
Function chromatin binding, proline-rich region binding, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (14)    Tissues (9)    Images (17)
Theiler Stages: 19, 20, 21, 22, 24, 26, 28
Assay TypeResults
Immunohistochemistry 12
RT-PCR 2
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000038037 (Evidence)
Ensembl Gene ModelENSMUSG00000053110 (Evidence)
Entrez Gene22601 (Evidence)
DFCITC1573055, TC1590080, TC1755918
DoTSDT.101737261, DT.494677, DT.91465455
NIA Mouse Gene IndexU030450
PDB3JUA
Consensus CDS ProjectCCDS40533.1, CCDS52718.1
International Mouse Knockout Project StatusYap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038037 VEGA Gene Model | MGI Sequence Detail 72598 C57BL/6J ±  kb
transcript OTTMUST00000097973 VEGA | MGI Sequence Detail 4171 Not Applicable 
polypeptide OTTMUSP00000054974 VEGA | MGI Sequence Detail 488 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(16) UniProt(7)
Polymorphisms SNPs within 2kb(332 from dbSNP Build 137)    SNPs within 2kb including multiple locations(334)
Protein-related
information
ResourceIDDescription
InterPro IPR001202 WW domain
Protein Ontology PR:000017522 yorkie homolog
References (Earliest) J:26090 Sudol M, et al., Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem. 1995 Jun 16;270(24):14733-41
(Latest) J:211315 Mori M, et al., Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell. 2014 Feb 27;156(5):893-906
All references(98)
Other
accession IDs
MGD-MRK-24140, MGI:2143022

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory