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Yap1 Gene Detail
Summary
  • Symbol
    Yap1
  • Name
    yes-associated protein 1
  • Synonyms
    Yap, Yki, yorkie
  • Feature Type
    protein coding gene
  • IDs
    MGI:103262
    NCBI Gene: 22601
  • Gene Overview
    MyGene.info: YAP1
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    YAP1, Yes associated protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    YAP1, Yes associated protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COB1, YAP, YAP2, YAP65, YKI
  • Links
    NCBI Gene ID: 10413
    neXtProt AC: NX_P46937
    UniProt: P46937

  • Chr Location
    11q22.1; chr11:102109957-102233423 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4452
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: YAP1
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    82 phenotypes from 9 alleles in 9 genetic backgrounds
    54 phenotypes from multigenic genotypes
    12 images
    105 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a null mutation of this gene die between embryonic days E9.5 and E10.5 due to yolk sac avasculogenesis and failure of attachment between the allantois and the chorion. Heterozygous mice are viable, appear normal and are fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000038037 VEGA Gene Model | MGI Sequence Detail 72598 C57BL/6J ±  kb
    transcript OTTMUST00000097973 VEGA | MGI Sequence Detail 4171 Not Applicable  
    polypeptide OTTMUSP00000054974 VEGA | MGI Sequence Detail 488 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      328 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 22
      cDNA 15
      Primer pair 7

      Microarray probesets 4
    Other
    Accession IDs
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    MGD-MRK-24140, MGI:2143022
    References
    more
    • Summaries
      All 234
      Developmental Gene Expression 87
      Diseases 1
      Gene Ontology 32
      Phenotypes 105
    • Earliest
      J:26090 Sudol M, et al., Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem. 1995 Jun 16;270(24):14733-41
    • Latest
      J:260794 Jeong SH, et al., Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer. J Clin Invest. 2018 Mar 1;128(3):1010-1025

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory