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Yap1 Gene Detail
Summary
  • Symbol
    Yap1
  • Name
    yes-associated protein 1
  • Synonyms
    Yap, Yki, yorkie
  • Feature Type
    protein coding gene
  • IDs
    MGI:103262
    NCBI Gene: 22601
  • Gene Overview
    MyGene.info: YAP1
Location & Maps
more
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    YAP1, Yes associated protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    YAP1, Yes associated protein 1
    Orthology source: HomoloGene
  • Synonyms
    COB1, YAP, YAP2, YAP65, YKI
  • Links
    NCBI Gene ID: 10413
    neXtProt AC: NX_P46937

  • Chr Location
    11q13; chr11:102110254-102233423 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4452
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: YAP1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human YAP1 associations

Human Disease Mouse Models
       Coloboma, Ocular, with or without Hearing Impairment, Cleft Lip/Palate, and/or Mental Retardation; COB1   OMIM: 120433
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    82 phenotypes from 9 alleles in 9 genetic backgrounds
    52 phenotypes from multigenic genotypes
    12 images
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    45
  • Gene trapped
    31
  • Targeted
    13
  • Transgenic
    1
  • Incidental Mutations
Embryos homozygous for a null mutation of this gene die between embryonic days E9.5 and E10.5 due to yolk sac avasculogenesis and failure of attachment between the allantois and the chorion. Heterozygous mice are viable, appear normal and are fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038037 VEGA Gene Model | MGI Sequence Detail 72598 C57BL/6J ±  kb
transcript OTTMUST00000097973 VEGA | MGI Sequence Detail 4171 Not Applicable  
polypeptide OTTMUSP00000054974 VEGA | MGI Sequence Detail 488 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    328 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000017522 transcriptional coactivator YAP1
  • PDB
  • InterPro Domains
    IPR001202 WW domain
Molecular
Reagents
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  • All nucleic 21
    cDNA 15
    Primer pair 6

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-24140, MGI:2143022
References
more
  • Summaries
    All 135
    Developmental Gene Expression 55
    Diseases 1
    Gene Ontology 28
    Phenotypes 57
  • Earliest
    J:26090 Sudol M, et al., Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem. 1995 Jun 16;270(24):14733-41
  • Latest
    J:232100 Huang Z, et al., Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex. J Neurosci. 2016 May 25;36(21):5833-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory