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Yap1 Gene Detail
Summary
  • Symbol
    Yap1
  • Name
    yes-associated protein 1
  • Synonyms
    Yap, Yki, yorkie
  • Feature Type
    protein coding gene
  • IDs
    MGI:103262
    NCBI Gene: 22601
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:7932000-8004597 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1785 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103262
 protein coding gene Chr9:7932000-8004890 (-)
129S1/SvImJ ENSMUSG00200022878
 protein coding gene Chr9:4816155-4889409 (-)
A/J ENSMUSG00195019137
 protein coding gene Chr9:4694938-4767547 (-)
AKR/J ENSMUSG00220018591
 protein coding gene Chr9:4869261-4942189 (-)
BALB/cJ ENSMUSG00180011442
 protein coding gene Chr9:4832808-4905422 (-)
C3H/HeJ ENSMUSG00175023274
 protein coding gene Chr9:4751866-4824465 (-)
C57BL/6NJ ENSMUSG00215006116
 protein coding gene Chr9:4768624-4841239 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031763
 protein coding gene Chr9:4148970-4222765 (-)
CAST/EiJ ENSTCUG00005007143
 protein coding gene Chr9:4820160-4892721 (-)
CBA/J ENSMUSG00210010508
 protein coding gene Chr9:4790804-4863415 (-)
DBA/2J ENSMUSG00185004880
 protein coding gene Chr9:4900819-4973426 (-)
FVB/NJ ENSMUSG00205007071
 protein coding gene Chr9:4880676-4953296 (-)
JF1/MsJ ENSUMUG00000006184
 protein coding gene Chr9:4936039-5008731 (-)
LP/J ENSMUSG00230003743
 protein coding gene Chr9:5363838-5437091 (-)
NOD/ShiLtJ ENSMUSG00190022010
 protein coding gene Chr9:4804258-4876827 (-)
NZO/HlLtJ ENSMUSG00225016924
 protein coding gene Chr9:5240387-5312992 (-)
PWK/PhJ ENSLUMG00010006315
 protein coding gene Chr9:4902260-4975443 (-)
SPRET/EiJ ENSMSPG00010005522
 protein coding gene Chr9:4961292-5030083 (-)
WSB/EiJ ENSIUOG00005007525
 protein coding gene Chr9:4700947-4774120 (-)



Homology
more
  • Human Ortholog
    YAP1, Yes1 associated transcriptional regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YAP1, Yes1 associated transcriptional regulator
  • Synonyms
    COB1, YAP, YAP-1, YAP2, YAP65, YKI
  • Links
    NCBI Gene ID: 10413
    UniProt: P46937

  • Chr Location
    11q22.1; chr11:102110099-102233424 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Yap1 mouse models; 1 with human YAP1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    94 phenotypes from 13 alleles in 14 genetic backgrounds
    32 phenotypes from multigenic genotypes
    12 images
    423 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a null mutation of this gene die between embryonic days E9.5 and E10.5 due to yolk sac avasculogenesis and failure of attachment between the allantois and the chorion. Heterozygous mice are viable, and fertile but exhibit age-dependent cone photoreceptor degeneration and retinal abnormalities. An inducible acetylation-blocking allele leads to improved post-injury cardiac regeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    183
  • GO References
    49
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1128
  • Tissues
    206
  • cDNA Data
    16
  • Literature Summary
    239
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053110 Ensembl Gene Model | MGI Sequence Detail 72598 C57BL/6J ±  kb
    transcript ENSMUST00000065353 Ensembl | MGI Sequence Detail 4171 Not Applicable  
    polypeptide ENSMUSP00000069554 Ensembl | MGI Sequence Detail 488 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 17
      Primer pair 12
      Antibodies 25

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24140, MGI:2143022
    References
    more
    • Summaries
      All 942
      Developmental Gene Expression 239
      Diseases 1
      Gene Ontology 49
      Phenotypes 423
    • Earliest
      J:26090 Sudol M, et al., Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem. 1995 Jun 16;270(24):14733-41
    • Latest
      J:391806 Hu Q, et al., Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling. Adv Sci (Weinh). 2026 Jul 16;:e10226
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory