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Grb10 Gene Detail
Summary
  • Symbol
    Grb10
  • Name
    growth factor receptor bound protein 10
  • Synonyms
    5730571D09Rik, maternally expressed gene 1, Meg1, mKIAA0207
  • Feature Type
    protein coding gene
  • IDs
    MGI:103232
    NCBI Gene: 14783
  • Gene Overview
    MyGene.info: GRB10
  • Alliance
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:11930499-12037422 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 7.15 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    356 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103232
protein coding gene Chr11:11930499-12038683 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018048
protein coding gene Chr11:9241721-9353448 (-)
A/J MGP_AJ_G0018021
protein coding gene Chr11:8910988-9020151 (-)
AKR/J MGP_AKRJ_G0017985
protein coding gene Chr11:9285623-9396453 (-)
BALB/cJ MGP_BALBcJ_G0017989
protein coding gene Chr11:8942351-9050492 (-)
C3H/HeJ MGP_C3HHeJ_G0017802
protein coding gene Chr11:9186505-9294477 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018441
protein coding gene Chr11:9551231-9662406 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016099
protein coding gene Chr11:8459356-8565160 (-)
CAST/EiJ MGP_CASTEiJ_G0017364
protein coding gene Chr11:9198347-9309843 (-)
CBA/J MGP_CBAJ_G0017777
protein coding gene Chr11:10239503-10349525 (-)
DBA/2J MGP_DBA2J_G0017887
protein coding gene Chr11:8839666-8948114 (-)
FVB/NJ MGP_FVBNJ_G0017879
protein coding gene Chr11:8755023-8863077 (-)
LP/J MGP_LPJ_G0017958
protein coding gene Chr11:9346525-9462482 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017905
protein coding gene Chr11:9963336-10073879 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018482
protein coding gene Chr11:9320704-9430471 (-)
PWK/PhJ MGP_PWKPhJ_G0017144
protein coding gene Chr11:8877348-8987512 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016941
protein coding gene Chr11:9153849-9273567 (-)
WSB/EiJ MGP_WSBEiJ_G0017418
protein coding gene Chr11:9067260-9180465 (-)



Homology
more
  • Human Ortholog
    GRB10, growth factor receptor bound protein 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRB10, growth factor receptor bound protein 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Grb-10, GRB-IR, IRBP, MEG1, RSS
  • Links
    NCBI Gene ID: 2887
    neXtProt AC: NX_Q13322
    UniProt: Q13322

  • Chr Location
    7p12.1; chr7:50590063-50793462 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3882
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GRB10
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 5 alleles in 6 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Maternal transmission of a mutant allele results in both fetal and placental overgrowth. Disproportionate overgrowth of the liver is observed. Paternal transmission of an allele lacking the differentially methylated region results in growth retardation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14783 NCBI Gene Model | MGI Sequence Detail 106924 C57BL/6J ±  kb
    transcript NM_010345 RefSeq | MGI Sequence Detail 5089 C57BL/6  
    polypeptide Q60760 UniProt | EBI | MGI Sequence Detail 621 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 1
      cDNA 39
      Primer pair 7
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-24105, MGI:1915227, MGI:2144128
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 38
      Diseases 1
      Gene Ontology 12
      Phenotypes 25
    • Earliest
      J:24927 Ooi J, et al., The cloning of Grb10 reveals a new family of SH2 domain proteins. Oncogene. 1995 Apr 20;10(8):1621-30
    • Latest
      J:258327 Holt LJ, et al., Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice. Endocrinology. 2018 Mar 1;159(3):1339-1351

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory