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Grb10
Gene Detail
Symbol

Name
ID
Grb10
growth factor receptor bound protein 10
MGI:103232
Synonyms
5730571D09Rik, maternally expressed gene 1, Meg1, mKIAA0207
Feature Type
protein coding gene
Genetic Map
Chromosome 11
7.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:11930508-12038683 bp, - strand
From VEGA annotation of GRCm38

  108176 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3882  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Grb10

Human
homologs
Human Homolog GRB10, growth factor receptor-bound protein 10
NCBI Gene ID 2887
neXtProt AC  NX_Q13322
Human Synonyms  Grb-10, GRB-IR, IRBP, MEG1, RSS
Human Chr (Location)  7p12.2; chr7:50590063-50793462 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(45) : Gene trapped(39) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Maternal transmission of a mutant allele results in both fetal and placental overgrowth. Disproportionate overgrowth of the liver is observed. Paternal transmission of an allele lacking the differentially methylated region results in growth retardation.
 
Interactions
Grb10 interacts with 334 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process insulin-like growth factor receptor signaling pathway, insulin receptor signaling pathway, ...
Component cytoplasm, cytosol
Function insulin receptor binding, phosphotyrosine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (421)    Tissues (62)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 391
RT-PCR 30
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) Genomic(1) cDNA(37) Primer pair(7) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000005165 (Evidence)
Ensembl Gene ModelENSMUSG00000020176 (Evidence)
Entrez Gene14783 (Evidence)
DFCITC1572295, TC1656656, TC1685243, TC1734988
DoTSDT.101142355, DT.101308184, DT.101404550, DT.101404552, DT.101404554, DT.495965, DT.97361289
NIA Mouse Gene IndexU032516
PDB3M7F
Consensus CDS ProjectCCDS24440.1, CCDS48754.1
International Mouse Knockout Project StatusGrb10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005165 VEGA Gene Model | MGI Sequence Detail 108176 C57BL/6J ±  kb
transcript OTTMUST00000011552 VEGA | MGI Sequence Detail 5061 Not Applicable 
polypeptide OTTMUSP00000005375 VEGA | MGI Sequence Detail 596 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(12) UniProt(7)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(360 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015042 BPS (Between PH and SH2) domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000159 Ras-association
InterPro IPR000980 SH2 domain
Protein Ontology PR:000008222 growth factor receptor-bound protein 10
References
(Earliest) J:24927 Ooi J, et al., The cloning of Grb10 reveals a new family of SH2 domain proteins. Oncogene. 1995 Apr 20;10(8):1621-30
(Latest) J:210349 Mainigi MA, et al., Peri-implantation hormonal milieu: elucidating mechanisms of abnormal placentation and fetal growth. Biol Reprod. 2014 Feb;90(2):26
All references(95)
Other
accession IDs
MGD-MRK-24105, MGI:1915227, MGI:2144128

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory