Grb10
Gene Detail

Symbol Name ID

Grb10 growth factor receptor bound protein 10 MGI:103232

Synonyms

5730571D09Rik, maternally expressed gene 1, Meg1, mKIAA0207

Feature Type

protein coding gene

Genetic Map

Chromosome 11

7.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:11930508-12038683 bp, - strand From VEGA annotation of GRCm38   108176 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3882  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Grb10

Human homologs

Human Homolog		GRB10, growth factor receptor-bound protein 10
NCBI Gene ID		2887
neXtProt AC		NX_Q13322
Human Synonyms		Grb-10, GRB-IR, IRBP, MEG1, RSS
Human Chr (Location)		7p12.2; chr7:50657760-50861159 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(44) : Targeted(5) Gene trapped(39)
 

Maternal transmission of a mutant allele results in both fetal and placental overgrowth. Disproportionate overgrowth of the liver is observed. Paternal transmission of an allele lacking the differentially methylated region results in growth retardation.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	insulin-like growth factor receptor signaling pathway, insulin receptor signaling pathway, ...
Component	cytoplasm, cytosol
Function	insulin receptor binding, phospholipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (30 records)
Data Summary: Results (421)    Tissues (61)    Images (42)
Theiler Stages: 13, 15, 17, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	391
RT-PCR	30

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) Genomic(1) cDNA(37) Primer pair(7) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000005165 (Evidence)
Ensembl Gene Model	ENSMUSG00000020176 (Evidence)
Entrez Gene	14783 (Evidence)
DFCI	TC1572295, TC1656656, TC1685243, TC1734988
DoTS	DT.101142355, DT.101308184, DT.101404550, DT.101404552, DT.101404554, DT.495965, DT.97361289
NIA Mouse Gene Index	U032516
PDB	3M7F
Consensus CDS Project	CCDS24440.1, CCDS48754.1
International Mouse Knockout Project Status	Grb10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005165	VEGA Gene Model | MGI Sequence Detail	108176	C57BL/6J
transcript	OTTMUST00000011552	VEGA | MGI Sequence Detail	5061	Not Applicable
polypeptide	OTTMUSP00000005375	VEGA | MGI Sequence Detail	596	Not Applicable

All sequences(79) RefSeq(4) UniProt(7)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(308 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015042	BPS (Between PH and SH2) domain
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR000159	Ras-association
InterPro	IPR000980	SH2 domain
Protein Ontology	PR:000008222	growth factor receptor-bound protein 10

References

(Earliest) J:24927 Ooi J, et al., The cloning of Grb10 reveals a new family of SH2 domain proteins. Oncogene. 1995 Apr 20;10(8):1621-30
(Latest) J:192195 Himes KP, et al., Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth. Dev Biol. 2013 Jan 1;373(1):72-82
All references(89)

Other accession IDs

MGD-MRK-24105, MGI:1915227, MGI:2144128