Grb10 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Grb10
growth factor receptor bound protein 10
MGI:103232

50 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Grb10^{Gt(Betageo)1Ward}/Grb10⁺ involves: C57BL/6 * CBA	abnormal pulmonary alveolus morphology	J:84425
	abnormal trachea morphology	J:84425
	enlarged liver	J:84425
	enlarged placenta	J:84425
	increased birth body size	J:84425
	increased fetal size	J:84425
	increased liver glycogen level	J:84425
	paternal imprinting	J:84425
	perinatal lethality, incomplete penetrance	J:84425
Grb10^{Gt(Betageo)1Ward}/Grb10^{Gt(Betageo)1Ward} involves: C57BL/6 * CBA	enlarged liver	J:84425
	enlarged placenta	J:84425
	increased birth body size	J:84425
	increased fetal size	J:84425
Grb10^GT(XC302)Byg/Grb10^GT(XC302)Byg involves: 129P2/OlaHsd	preweaning lethality, complete penetrance	J:207675
Grb10^GT(XC302)Byg/Grb10^GT(XC302)Byg involves: 129P2/OlaHsd * Black Swiss * C57BL/6	increased body weight	J:125128
	increased insulin sensitivity	J:125128
	increased lean body mass	J:125128
	increased lung weight	J:125128
	increased muscle weight	J:125128
	increased pancreas weight	J:125128
Grb10^tm1.1Fliu/Grb10^tm1.1Fliu Tg(Adipoq-cre)#Pesch/0 involves: 129S/SvEv * FVB	abnormal adipose tissue physiology	J:213603
	abnormal brown adipose tissue physiology	J:213603
	abnormal epididymal fat pad morphology	J:213603
	abnormal interscapular fat pad morphology	J:213603
	decreased core body temperature	J:213603
	decreased fatty acid oxidation	J:213603
	decreased oxygen consumption	J:213603
	hepatic steatosis	J:213603
	impaired adaptive thermogenesis	J:213603
	impaired glucose tolerance	J:213603
	increased body fat mass	J:213603
	increased body weight	J:213603
	increased brown fat cell size	J:213603
	increased circulating insulin level	J:213603
	increased susceptibility to age related obesity	J:213603
	increased susceptibility to diet-induced obesity	J:213603
	increased white fat cell size	J:213603
	insulin resistance	J:213603
	whitened brown adipose tissue morphology	J:213603
Grb10^tm1.1Fliu/Grb10^tm1.1Fliu Tg(Fabp4-cre)1Rev/0 involves: 129S/SvEv	abnormal epididymal fat pad morphology	J:213603
	hepatic steatosis	J:213603
	impaired glucose tolerance	J:213603
	increased body fat mass	J:213603
	increased body weight	J:213603
	increased brown fat cell size	J:213603
	increased circulating insulin level	J:213603
	increased susceptibility to age related obesity	J:213603
	increased susceptibility to diet-induced obesity	J:213603
	increased white fat cell size	J:213603
	insulin resistance	J:213603
	whitened brown adipose tissue morphology	J:213603
Grb10^tm1.1Fliu/Grb10^tm1.1Fliu Tg(Pdx1-cre)6Tuv/0 involves: 129S/SvEv * C57BL/6 * FVB/N	abnormal glucose homeostasis	J:208498
	abnormal pancreatic beta cell morphology	J:208498
	abnormal pancreatic beta cell physiology	J:208498
	decreased circulating glucose level	J:208498
	decreased susceptibility to weight loss	J:208498
	normal homeostasis/metabolism phenotype	J:208498
	improved glucose tolerance	J:208498
	increased insulin secretion	J:208498
	increased pancreas weight	J:208498
	increased pancreatic beta cell mass	J:208498
	increased pancreatic beta cell proliferation	J:208498
Grb10^tm1.1Fuis/Grb10⁺ involves: 129S/SvEv * C57BL/6J	decreased body weight	J:146865
	decreased fetal size	J:146865
	decreased placenta weight	J:146865
	embryonic growth retardation	J:146865
	small placenta	J:146865
Grb10^tm1Fuis/Grb10⁺ involves: 129S/SvEv * C57BL/6J	normal growth/size/body region phenotype	J:146865

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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