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Nqo1 Gene Detail
Summary
  • Symbol
    Nqo1
  • Name
    NAD(P)H dehydrogenase, quinone 1
  • Synonyms
    Dia4, NAD(P)H dehydrogenase (quinone), NMO1, Nmor1, NQO1, Ox-1, Ox1, QR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103187
    NCBI Gene: 18104
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:108114857-108129838 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 54.08 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    528 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103187
 protein coding gene Chr8:108114856-108139012 (-)
129S1/SvImJ ENSMUSG00200013643
 protein coding gene Chr8:102396501-102411495 (-)
A/J ENSMUSG00195016563
 protein coding gene Chr8:102718929-102733926 (-)
AKR/J ENSMUSG00220014406
 protein coding gene Chr8:102857926-102872921 (-)
BALB/cJ ENSMUSG00180019566
 protein coding gene Chr8:102724636-102739629 (-)
C3H/HeJ ENSMUSG00175024231
 protein coding gene Chr8:102781668-102796655 (-)
C57BL/6NJ ENSMUSG00215018846
 protein coding gene Chr8:102394520-102409502 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031535
 protein coding gene Chr8:98518896-98533856 (-)
CAST/EiJ ENSTCUG00005030392
 protein coding gene Chr8:102155717-102170722 (-)
CBA/J ENSMUSG00210031348
 protein coding gene Chr8:102708997-102723983 (-)
DBA/2J ENSMUSG00185004872
 protein coding gene Chr8:108817782-108832771 (-)
FVB/NJ ENSMUSG00205015389
 protein coding gene Chr8:101692620-101707613 (-)
JF1/MsJ ENSUMUG00000005672
 protein coding gene Chr8:111150947-111165935 (-)
LP/J ENSMUSG00230035120
 protein coding gene Chr8:112498001-112512991 (-)
NOD/ShiLtJ ENSMUSG00190021084
 protein coding gene Chr8:102843228-102858212 (-)
NZO/HlLtJ ENSMUSG00225020153
 protein coding gene Chr8:115848621-115863609 (-)
PWK/PhJ ENSLUMG00010025655
 protein coding gene Chr8:102628609-102643873 (-)
SPRET/EiJ ENSMSPG00010032603
 protein coding gene Chr8:104696490-104712963 (-)
WSB/EiJ ENSIUOG00005027650
 protein coding gene Chr8:103527860-103543048 (-)



Homology
more
  • Human Ortholog
    NQO1, NAD(P)H quinone dehydrogenase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NQO1, NAD(P)H quinone dehydrogenase 1
  • Synonyms
    DHQU, DIA4, DTD, NMOR1, NMORI, QR1
  • Links
    NCBI Gene ID: 1728
    UniProt: P15559

  • Chr Location
    16q22.1; chr16:69706996-69726668 (-)  GRCh38
Human Diseases
more
  • Diseases
    13 with human NQO1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted null mice display increased toxicity to menadione, insulin resistance, an altered intracellular redox status, as well as decreased pyridine nucleotide synthesis, gluconeogenesis and fatty acid metabolism, leading to reduced quantities of abdominal adipose tissue.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    18
  • cDNA Data
    33
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003849 Ensembl Gene Model | MGI Sequence Detail 14982 C57BL/6J ±  kb
    transcript ENSMUST00000003947 Ensembl | MGI Sequence Detail 1553 Not Applicable  
    polypeptide ENSMUSP00000003947 Ensembl | MGI Sequence Detail 274 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 1
      cDNA 35
      Primer pair 3
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13090, MGD-MRK-13092, MGD-MRK-19559, MGD-MRK-24055, MGI:2142727
    References
    more
    • Summaries
      All 196
      Developmental Gene Expression 35
      Gene Ontology 16
      Phenotypes 46
    • Earliest
      J:5757 Kumaki K, et al., Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse. J Biol Chem. 1977 Jan 10;252(1):157-65
    • Latest
      J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory