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Nqo1
Gene Detail
Symbol

Name
ID
Nqo1
NAD(P)H dehydrogenase, quinone 1
MGI:103187
Synonyms
Dia4, NAD(P)H dehydrogenase (quinone), NMO1, Nmor1, NQO1, Ox1, Ox-1, QR1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
54.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr8:107388225-107403206 bp, - strand
From VEGA annotation of GRCm38

  14982 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NQO1
Protein SuperFamily: NAD(P)H dehydrogenase (quinone) 2
Gene Tree: Nqo1

Human
homologs
NQO1, NAD(P)H dehydrogenase, quinone 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1728
neXtProt AC: NX_P15559

Human Synonyms: DHQU, DIA4, DTD, NMOR1, NMORI, QR1

Human Chr (Location): 16q22.1; chr16:69709401-69726668 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NQO1

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(12) Targeted(6)
Incidental mutations (data from APF )
 
Targeted null mice display increased toxicity to menadione, insulin resistance, an altered intracellular redox status, as well as decreased pyridine nucleotide synthesis, gluconeogenesis and fatty acid metabolism, leading to reduced quantities of abdominal adipose tissue.
 
Interactions
Nqo1 interacts with 90 markers (Mir7-2, Mir7b, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process negative regulation of catalytic activity, oxidation-reduction process, ...
Component cytoplasm, cytosol, ...
Function identical protein binding, NAD(P)H dehydrogenase (quinone) activity, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (21)    Tissues (7)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 12
Northern blot 7
RT-PCR 2
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nqo1    NEW 
Molecular
reagents
All nucleic(35) Genomic(1) cDNA(33) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000022884 (Evidence)
Ensembl Gene Model ENSMUSG00000003849 (Evidence)
Entrez Gene 18104 (Evidence)
UniGene 252
DFCI TC1605949, TC1583756
DoTS DT.530763
NIA Mouse Gene Index U237128, U030215
EC 1.6.5.2
PDB 1DXQ
Consensus CDS Project CCDS40465.1
International Mouse Phenotyping Consortium Status Nqo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022884 VEGA Gene Model | MGI Sequence Detail 14982 C57BL/6J ±  kb
transcript OTTMUST00000055042 VEGA | MGI Sequence Detail 1553 Not Applicable 
polypeptide OTTMUSP00000026299 VEGA | MGI Sequence Detail 274 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003680 Flavodoxin-like fold
Protein Ontology PR:000011388 NAD(P)H dehydrogenase [quinone] 1
References
(Earliest) J:5757 Kumaki K, et al., Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse. J Biol Chem. 1977 Jan 10;252(1):157-65
(Latest) J:211507 Gang GT, et al., Protection of NAD(P)H:quinone oxidoreductase 1 against renal ischemia/reperfusion injury in mice. Free Radic Biol Med. 2014 Feb;67:139-49
All references(104)
Other
accession IDs
MGD-MRK-13090, MGD-MRK-13092, MGD-MRK-19559, MGD-MRK-24055, MGI:2142727

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory