Nqo1
Gene Detail

Symbol Name ID

Nqo1 NAD(P)H dehydrogenase, quinone 1 MGI:103187

Synonyms

Dia4, NAD(P)H dehydrogenase (quinone), NMO1, Nmor1, NQO1, Ox1, Ox-1, QR1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

54.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr8:107388225-107403206 bp, - strand From VEGA annotation of GRCm38   14982 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: NAD(P)H dehydrogenase (quinone) 2
Gene Tree: Nqo1

Human homologs

Human Homolog		NQO1, NAD(P)H dehydrogenase, quinone 1
NCBI Gene ID		1728
neXtProt AC		NX_P15559
Human Synonyms		DHQU, DIA4, DTD, NMOR1, NMORI, QR1
Human Chr (Location)		16q22.1; chr16:69743304-69760533 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NQO1

Alleles and phenotypes

All alleles(18) : Targeted(6) Gene trapped(12)
 

Targeted null mice display increased toxicity to menadione, insulin resistance, an altered intracellular redox status, as well as decreased pyridine nucleotide synthesis, gluconeogenesis and fatty acid metabolism, leading to reduced quantities of abdominal adipose tissue.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	negative regulation of catalytic activity, oxidation-reduction process, ...
Component	cytoplasm, cytosol, ...
Function	NAD(P)H dehydrogenase (quinone) activity, oxidoreductase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (21)    Tissues (7)    Images (7)
Theiler Stages: 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	12
Northern blot	7
RT-PCR	2

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(35) Genomic(1) cDNA(33) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000022884 (Evidence)
Ensembl Gene Model	ENSMUSG00000003849 (Evidence)
Entrez Gene	18104 (Evidence)
UniGene	252
DFCI	TC1583756, TC1605949
DoTS	DT.530763
NIA Mouse Gene Index	U030215, U237128
EC	1.6.5.2
PDB	1DXQ
Consensus CDS Project	CCDS40465.1
International Mouse Knockout Project Status	Nqo1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022884	VEGA Gene Model | MGI Sequence Detail	14982	C57BL/6J
transcript	OTTMUST00000055042	VEGA | MGI Sequence Detail	1553	Not Applicable
polypeptide	OTTMUSP00000026299	VEGA | MGI Sequence Detail	274	Not Applicable

All sequences(26) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(22 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003680	Flavodoxin-like fold
Protein Ontology	PR:000011388	NAD(P)H dehydrogenase [quinone] 1

References

(Earliest) J:5757 Kumaki K, et al., Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse. J Biol Chem. 1977 Jan 10;252(1):157-65
(Latest) J:193416 Xu J, et al., NAD(P)H:quinone oxidoreductase 1 (NQO1) competes with 20S proteasome for binding with C/EBPalpha leading to its stabilization and protection against radiation-induced myeloproliferative disease. J Biol Chem. 2012 Dec 7;287(50):41608-18
All references(99)

Other accession IDs

MGD-MRK-13090, MGD-MRK-13092, MGD-MRK-19559, MGD-MRK-24055, MGI:2142727