About   Help   FAQ
Gfi1
Gene Detail
Symbol

Name
ID
Gfi1
growth factor independent 1
MGI:103170
Synonyms
Gfi-1, Pal1, Pal-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
52.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr5:107716657-107726036 bp, - strand
From VEGA annotation of GRCm38

  9380 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3854  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gfi1

Human
homologs
Human Homolog GFI1, growth factor independent 1 transcription repressor
NCBI Gene ID 2672
neXtProt AC  NX_Q99684
Human Synonyms  GFI-1, GFI1A, SCN2, ZNF163
Human Chr (Location)  1p22; chr1:92474761-92486876 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human GFI1
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Chemically induced (ENU)(1) Targeted(15)
 
Homozygotes for targeted null mutations exhibit loss of inner ear hair cells, ataxia, circling, and deafness. Mutants also show a block in granulocyte and neutrophil maturation, and are hypersensitive to endotoxin stimulation.
 
Human Diseases Modeled Using Mouse Gfi1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Gfi1 interacts with 177 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process auditory receptor cell differentiation, cell fate commitment, ...
Component nuclear body, nuclear matrix, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (138)    Tissues (127)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RNA in situ 127
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(19) cDNA(12) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033123 (Evidence)
Ensembl Gene ModelENSMUSG00000029275 (Evidence)
Entrez Gene14581 (Evidence)
DFCITC1720322, TC1587097, TC1585577
DoTSDT.101724021, DT.489041, DT.94285281, DT.94285282
NIA Mouse Gene IndexU026521
Consensus CDS ProjectCCDS57371.1, CCDS59680.1
International Mouse Knockout Project StatusGfi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033123 VEGA Gene Model | MGI Sequence Detail 9380 C57BL/6J ±  kb
transcript OTTMUST00000082810 VEGA | MGI Sequence Detail 2860 Not Applicable 
polypeptide OTTMUSP00000062808 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(12) UniProt(13)
Polymorphisms
RFLP(1) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
InterPro IPR001878 Zinc finger, CCHC-type
Protein Ontology PR:000007941 zinc finger protein Gfi-1
References
(Earliest) J:11213 van Lohuizen M, et al., Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging [see comments]. Cell. 1991 May 31;65(5):737-52
(Latest) J:211047 Shi F, et al., beta-Catenin is required for hair-cell differentiation in the cochlea. J Neurosci. 2014 May 7;34(19):6470-9
All references(122)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13127, MGD-MRK-13128, MGD-MRK-24036, MGI:2141203, MGI:97474

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory