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Gfi1 Gene Detail
Summary
  • Symbol
    Gfi1
  • Name
    growth factor independent 1
  • Synonyms
    Gfi-1, Pal1, Pal-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103170
    NCBI Gene: 14581
  • Gene Overview
    MyGene.info: GFI1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:107716657-107726036 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9380 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 52.23 cM
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    GFI1, growth factor independent 1 transcriptional repressor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GFI1, growth factor independent 1 transcriptional repressor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GFI-1, GFI1A, SCN2, ZNF163
  • Links
    NCBI Gene ID: 2672
    neXtProt AC: NX_Q99684
    UniProt: Q99684

  • Chr Location
    1p22.1; chr1:92473043-92486876 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3854
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GFI1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Gfi1 mouse models; 1 with human GFI1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    66 phenotypes from 9 alleles in 7 genetic backgrounds
    21 phenotypes from multigenic genotypes
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit loss of inner ear hair cells, ataxia, circling, and deafness. Mutants also show a block in granulocyte and neutrophil maturation, and are hypersensitive to endotoxin stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033123 VEGA Gene Model | MGI Sequence Detail 9380 C57BL/6J ±  kb
    transcript OTTMUST00000082810 VEGA | MGI Sequence Detail 2860 Not Applicable  
    polypeptide OTTMUSP00000062808 VEGA | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      64 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • InterPro Domains
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
      IPR029840 Zinc finger protein Gfi-1/1b
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 19
      cDNA 12
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13127, MGD-MRK-13128, MGD-MRK-24036, MGI:2141203, MGI:97474
    References
    more
    • Summaries
      All 158
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 13
      Phenotypes 83
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:260847 Wiwatpanit T, et al., Codeficiency of Lysosomal Mucolipins 3 and 1 in Cochlear Hair Cells Diminishes Outer Hair Cell Longevity and Accelerates Age-Related Hearing Loss. J Neurosci. 2018 Mar 28;38(13):3177-3189

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory