About   Help   FAQ
Gfi1 Gene Detail
Summary
  • Symbol
    Gfi1
  • Name
    growth factor independent 1
  • Synonyms
    Gfi-1, Pal1, Pal-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103170
    NCBI Gene: 14581
  • Gene Overview
    MyGene.info: GFI1
Location & Maps
more
  • Sequence Map
    Chr5:107716657-107726036 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9380 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 52.23 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    GFI1, growth factor independent 1 transcriptional repressor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GFI1, growth factor independent 1 transcriptional repressor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GFI-1, GFI1A, SCN2, ZNF163
  • Links
    NCBI Gene ID: 2672
    neXtProt AC: NX_Q99684

  • Chr Location
    1p22; chr1:92473043-92486876 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3854
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GFI1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Gfi1 mouse models; 2 with human GFI1 associations

Human Disease Mouse Models
       Neutropenia, Severe Congenital, 2, Autosomal Dominant; SCN2   OMIM: 613107 View 1 model
       Neutropenia, Nonimmune Chronic Idiopathic, of Adults   OMIM: 607847
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 9 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    15
  • Genomic Mutations
    3 involving Gfi1
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit loss of inner ear hair cells, ataxia, circling, and deafness. Mutants also show a block in granulocyte and neutrophil maturation, and are hypersensitive to endotoxin stimulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033123 VEGA Gene Model | MGI Sequence Detail 9380 C57BL/6J ±  kb
transcript OTTMUST00000082810 VEGA | MGI Sequence Detail 2860 Not Applicable  
polypeptide OTTMUSP00000062808 VEGA | MGI Sequence Detail 423 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    64 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000007941 zinc finger protein Gfi-1
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
    IPR029840 Zinc finger protein Gfi-1/1b
Molecular
Reagents
less
  • All nucleic 34
    Genomic 19
    cDNA 12
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13127, MGD-MRK-13128, MGD-MRK-24036, MGI:2141203, MGI:97474
References
more
  • Summaries
    All 125
    Developmental Gene Expression 18
    Diseases 1
    Gene Ontology 14
    Phenotypes 71
  • Earliest
    J:11213 van Lohuizen M, et al., Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging [see comments]. Cell. 1991 May 31;65(5):737-52
  • Latest
    J:217036 Sato A, et al., Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking. Leukemia. 2015 Jan;29(1):145-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory