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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Gfi1
growth factor independent 1 transcription repressor
MGI:103170
68 phenotypes from 10 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Gfi1Gen/Gfi1+
C57BL/6J-Gfi1Gen
abnormal myelopoiesis J:182679
abnormal NK cell differentiation J:182679
abnormal NK cell physiology J:182679
absent neutrophils J:182679
decreased NK cell degranulation J:182679
normal immune system phenotype J:182679
Gfi1tm1.1Wep/Gfi1tm1.1Wep
B6.129-Gfi1tm1.1Wep
arrested T cell differentiation J:117105
decreased B cell number J:117105
decreased body size J:117105
small thymus J:117105
thymus hypoplasia J:117105
Gfi1tm1Sho/Gfi1tm1Sho
involves: 129S1/Sv * C57BL/6J
abnormal cochlear hair cell development J:80025
abnormal cochlear hair cell morphology J:80025
abnormal cochlear OHC efferent innervation pattern J:80025
abnormal outer hair cell stereociliary bundle morphology J:80025
abnormal vestibular hair cell morphology J:80025
absent startle reflex J:80025
ataxia J:80025
circling J:80025
cochlear ganglion degeneration J:80025
cochlear hair cell degeneration J:80025
cochlear inner hair cell degeneration J:80025
cochlear outer hair cell degeneration J:80025
deafness J:80025
decreased body size J:80025
decreased cochlear outer hair cell number J:80025
degeneration of organ of Corti supporting cells J:80025
head tilt J:80025
hyperactivity J:80025
increased vestibular hair cell number J:80025
organ of Corti degeneration J:80025
postnatal growth retardation J:80025
premature death J:80025
Gfi1tm1Tmo/Gfi1tm1Tmo
involves: 129S1/Sv * 129X1/SvJ
decreased B cell number J:192927
decreased granulocyte number J:192927
decreased neutrophil cell number J:192927
decreased thymocyte number J:192927
increased hematopoietic stem cell number J:192927
increased monocyte cell number J:192927
Gfi1tm1Tmo/Gfi1tm1Tmo
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal cochlear inner hair cell morphology J:92833
abnormal cochlear outer hair cell morphology J:92833
abnormal cytokine secretion J:75143
abnormal granulocyte differentiation J:75143
abnormal inner hair cell stereociliary bundle morphology J:92833
abnormal monocyte differentiation J:75143
abnormal myelopoiesis J:75143
abnormal outer hair cell stereociliary bundle morphology J:92833
abnormal T cell differentiation J:75143
abnormal vestibular system physiology J:92833
cochlear outer hair cell degeneration J:92833
deafness J:92833
decreased B cell number J:75143
decreased body weight J:75143
decreased granulocyte number J:75143
decreased lymphocyte cell number J:75143
decreased neutrophil cell number J:75143
decreased T cell number J:75143
decreased thymocyte number J:75143
increased interleukin-1 beta secretion J:75143
increased interleukin-10 secretion J:75143
increased susceptibility to endotoxin shock J:75143
increased tumor necrosis factor secretion J:75143
premature death J:75143
short inner hair cell stereocilia J:92833
Gfi1tm1Wep/Gfi1tm1Wep
B6.129-Gfi1tm1Wep
abnormal definitive hematopoiesis J:117105
abnormal T cell proliferation J:117105
decreased body size J:117105
Gfi1tm1Wep/Gfi1tm1Wep
Tg(Cd4-cre)1Cwi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
abnormal T cell proliferation J:117105
abnormal T cell subpopulation ratio J:117105
abnormal T-helper 2 physiology J:117105
Gfi1tm2.1(GFP/cre/ERT2)Gan/Gfi1+
B6.Cg-Gfi1tm2.1(GFP/cre/ERT2)Gan/Gan
no abnormal phenotype detected J:297267
Gfi1tm2.1(GFP/cre/ERT2)Gan/Gfi1tm2.1(GFP/cre/ERT2)Gan
B6.Cg-Gfi1tm2.1(GFP/cre/ERT2)Gan/Gan
normal hearing/vestibular/ear phenotype J:297267
no abnormal phenotype detected J:297267
Gfi1tm2Tmo/Gfi1tm2Tmo
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal T cell differentiation J:93337
decreased neutrophil cell number J:93337
decreased thymocyte number J:93337
Gfi1tm3(Gfib1)Tmo/Gfi1tm3(Gfib1)Tmo
involves: 129S1/Sv * 129X1/SvJ
abnormal cochlear inner hair cell morphology J:116870
abnormal cochlear outer hair cell morphology J:116870
abnormal monocyte morphology J:116870
absent outer hair cell stereocilia J:116870
absent pinna reflex J:116870
cochlear outer hair cell degeneration J:116870
deafness J:116870
decreased granulocyte number J:116870
head bobbing J:116870
normal hematopoietic system phenotype J:116870
increased or absent threshold for auditory brainstem response J:116870
Gfi1tm4Tmo/Gfi1tm4Tmo
involves: 129S1/Sv * 129X1/SvJ
abnormal cochlear inner hair cell morphology J:116870
abnormal cochlear outer hair cell morphology J:116870
abnormal lymphopoiesis J:116870
abnormal monocyte morphology J:116870
abnormal neutrophil morphology J:116870
abnormal T cell differentiation J:116870
abnormal vestibular system physiology J:116870
absent outer hair cell stereocilia J:116870
absent pinna reflex J:116870
cochlear outer hair cell degeneration J:116870
deafness J:116870
decreased double-negative T cell number J:116870
decreased lymphocyte cell number J:116870
decreased neutrophil cell number J:116870
decreased thymocyte number J:116870
Gfi1tm6.1(GFI1)Tmo/Gfi1tm6.1(GFI1)Tmo
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
normal hematopoietic system phenotype J:192927

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory