Gfi1^tm4Tmo
Targeted Allele Detail

Summary

• Symbol: Gfi1^tm4Tmo
• Name: growth factor independent 1 transcription repressor; targeted mutation 4, Tarik Moroy
• MGI ID: MGI:3695404
• Synonyms: Gfi1^P2A, Gfi1:P2A
• Gene: Gfi1 Location: Chr5:107864521-107873671 bp, - strand Genetic Position: Chr5, 52.23 cM
• Alliance: Gfi1^tm4Tmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116870
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A C to G transversion was inserted at position 4 of the coding sequence, resulting in the substitution of alanine for proline at codon 2 (P2A). (J:116870)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfi1 Mutation: 31 strains or lines available

References

• Original: J:116870 Fiolka K, et al., Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development. EMBO Rep. 2006 Mar;7(3):326-33
• All: 3 reference(s)