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Dnase1 Gene Detail
Summary
  • Symbol
    Dnase1
  • Name
    deoxyribonuclease I
  • Synonyms
    DNaseI, Dnl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103157
    NCBI Gene: 13419
  • Gene Overview
    MyGene.info: DNASE1
Location & Maps
more
  • Genetic Map
    Chromosome 16, 2.37 cM, cytoband A1-A3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    DNASE1, deoxyribonuclease I
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNASE1, deoxyribonuclease I
    Orthology source: HomoloGene
  • Synonyms
    DNL1, DRNI
  • Links
    NCBI Gene ID: 1773
    neXtProt AC: NX_P24855

  • Chr Location
    16p13.3; chr16:3611745-3662875 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Dnase1 mouse models; 1 with human DNASE1 associations

Human Disease Mouse Models
       Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Some heterozygote and homozygote null mice have autoimmune symptoms similar to systemic lupus erythematosus. These include enlarged lymph nodes, circulating auto-antibodies, kidney inflammation and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027161 VEGA Gene Model | MGI Sequence Detail 3083 C57BL/6J ±  kb
transcript OTTMUST00000067185 VEGA | MGI Sequence Detail 1480 Not Applicable  
polypeptide OTTMUSP00000033767 VEGA | MGI Sequence Detail 284 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    21 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 213
    cDNA 211
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-24023, MGI:2146484
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:22846 Peitsch MC, et al., Genomic organisation and expression of mouse deoxyribonuclease I. Biochem Biophys Res Commun. 1995 Feb 6;207(1):62-8
  • Latest
    J:209292 Rossaint J, et al., Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation. Blood. 2014 Apr 17;123(16):2573-84

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory