Dnase1
Gene Detail

Symbol Name ID

Dnase1 deoxyribonuclease I MGI:103157

Synonyms

DNaseI, Dnl1

Feature Type

protein coding gene

Genetic Map

Chromosome 16

2.37 cM, cytoband A1-A3
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr16:4036942-4040024 bp, + strand From VEGA annotation of GRCm38   3083 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3826  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: deoxyribonuclease I
Gene Tree: Dnase1

Human homologs

Human Homolog		DNASE1, deoxyribonuclease I
NCBI Gene ID		1773
neXtProt AC		NX_P24855
Human Synonyms		DNL1, DRNI
Human Chr (Location)		16p13.3; chr16:3702940-3708096 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DNASE1

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Some heterozygote and homozygote null mice have autoimmune symptoms similar to systemic lupus erythematosus. These include enlarged lymph nodes, circulating auto-antibodies, kidney inflammation and premature death.

 
Human Diseases Modeled Using Mouse Dnase1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	apoptotic process, DNA catabolic process
Component	extracellular region, nucleus
Function	actin binding, deoxyribonuclease activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(211)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(213) cDNA(211) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000027161 (Evidence)
Ensembl Gene Model	ENSMUSG00000005980 (Evidence)
Entrez Gene	13419 (Evidence)
UniGene	440565
DFCI	TC1576582, TC1592268, TC1769749
DoTS	DT.101373437, DT.55243962, DT.94396515, DT.94396570, DT.97383908, DT.97383914
NIA Mouse Gene Index	U016756
EC	3.1.21.1
Consensus CDS Project	CCDS27913.1
International Mouse Knockout Project Status	Dnase1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027161	VEGA Gene Model | MGI Sequence Detail	3083	C57BL/6J
transcript	OTTMUST00000067185	VEGA | MGI Sequence Detail	1480	Not Applicable
polypeptide	OTTMUSP00000033767	VEGA | MGI Sequence Detail	284	Not Applicable

All sequences(68) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(13 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018057	Deoxyribonuclease I, active site
InterPro	IPR008185	Deoxyribonuclease I, eukaryotic
InterPro	IPR016202	Deoxyribonuclease I-like
InterPro	IPR005135	Endonuclease/exonuclease/phosphatase
Protein Ontology	PR:000006592	deoxyribonuclease-1

References

(Earliest) J:22846 Peitsch MC, et al., Genomic organisation and expression of mouse deoxyribonuclease I. Biochem Biophys Res Commun. 1995 Feb 6;207(1):62-8
(Latest) J:187124 Thiyagarajan D, et al., Silencing of renal DNaseI in murine lupus nephritis imposes exposure of large chromatin fragments and activation of Toll like receptors and the Clec4e. PLoS One. 2012;7(3):e34080
All references(41)

Other accession IDs

MGD-MRK-24023, MGI:2146484