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Dnase1
Gene Detail
Symbol

Name
ID
Dnase1
deoxyribonuclease I
MGI:103157
Synonyms
DNaseI, Dnl1
Feature Type
protein coding gene
Genetic Map
Chromosome 16
2.37 cM, cytoband A1-A3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:4036942-4040024 bp, + strand
From VEGA annotation of GRCm38

  3083 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3826  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DNASE1
Protein SuperFamily: deoxyribonuclease I
Gene Tree: Dnase1

Human
homologs
DNASE1, deoxyribonuclease I
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1773
neXtProt AC: NX_P24855

Human Synonyms: DNL1, DRNI

Human Chr (Location): 16p13.3; chr16:3611745-3662875 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DNASE1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Some heterozygote and homozygote null mice have autoimmune symptoms similar to systemic lupus erythematosus. These include enlarged lymph nodes, circulating auto-antibodies, kidney inflammation and premature death.
 
Human Diseases Modeled in Mice Using Dnase1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Dnase1 interacts with 47 markers (Mir16-1, Mir29a, Mir128-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process apoptotic process, DNA catabolic process, ...
Component extracellular exosome, extracellular region, ...
Function actin binding, deoxyribonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(211)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100492611 ; ZFIN dnase1    NEW 
Molecular
reagents
All nucleic(213) cDNA(211) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027161 (Evidence)
Ensembl Gene Model ENSMUSG00000005980 (Evidence)
Entrez Gene 13419 (Evidence)
UniGene 440565
DFCI TC1769749, TC1576582, TC1592268
DoTS DT.94396570, DT.101373437, DT.94396515, DT.55243962, DT.97383914, DT.97383908
NIA Mouse Gene Index U016756
EC 3.1.21.1
Consensus CDS Project CCDS27913.1
International Mouse Phenotyping Consortium Status Dnase1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027161 VEGA Gene Model | MGI Sequence Detail 3083 C57BL/6J ±  kb
transcript OTTMUST00000067185 VEGA | MGI Sequence Detail 1480 Not Applicable 
polypeptide OTTMUSP00000033767 VEGA | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(8) UniProt(8)
Polymorphisms
SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018057 Deoxyribonuclease I, active site
InterPro IPR016202 Deoxyribonuclease I-like
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
Protein Ontology PR:000006592 deoxyribonuclease-1
References
(Earliest) J:22846 Peitsch MC, et al., Genomic organisation and expression of mouse deoxyribonuclease I. Biochem Biophys Res Commun. 1995 Feb 6;207(1):62-8
(Latest) J:209292 Rossaint J, et al., Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation. Blood. 2014 Apr 17;123(16):2573-84
All references(46)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-24023, MGI:2146484

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory