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Dnase1
Gene Detail
 Symbol
Name
ID
Dnase1
deoxyribonuclease I
MGI:103157
Synonyms DNaseI, Dnl1
Feature Type protein coding gene
Genetic Map
Chromosome 16
2.37 cM, cytoband A1-A3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:4036942-4040024 bp, + strand
From VEGA annotation of GRCm38

  3083 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3826  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: deoxyribonuclease I
Gene Tree: Dnase1

Human
homologs
Human Homolog DNASE1, deoxyribonuclease I
NCBI Gene ID 1773
neXtProt AC  NX_P24855
Human Synonyms  DNL1, DRNI
Human Chr (Location)  16p13.3; chr16:3640655-3662688 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DNASE1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Some heterozygote and homozygote null mice have autoimmune symptoms similar to systemic lupus erythematosus. These include enlarged lymph nodes, circulating auto-antibodies, kidney inflammation and premature death.
 
Human Diseases Modeled Using Mouse Dnase1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Dnase1 interacts with 47 markers (Mir16-1, Mir29a, Mir128-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process apoptotic process, DNA catabolic process, ...
Component extracellular region, extracellular vesicular exosome, ...
Function actin binding, deoxyribonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(211)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(213) cDNA(211) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027161 (Evidence)
Ensembl Gene ModelENSMUSG00000005980 (Evidence)
Entrez Gene13419 (Evidence)
UniGene440565
DFCITC1576582, TC1592268, TC1769749
DoTSDT.101373437, DT.55243962, DT.94396515, DT.94396570, DT.97383908, DT.97383914
NIA Mouse Gene IndexU016756
EC3.1.21.1
Consensus CDS ProjectCCDS27913.1
International Mouse Knockout Project StatusDnase1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027161 VEGA Gene Model | MGI Sequence Detail 3083 C57BL/6J ±  kb
transcript OTTMUST00000067185 VEGA | MGI Sequence Detail 1480 Not Applicable 
polypeptide OTTMUSP00000033767 VEGA | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(8) UniProt(8)
Polymorphisms SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018057 Deoxyribonuclease I, active site
InterPro IPR016202 Deoxyribonuclease I-like
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
Protein Ontology PR:000006592 deoxyribonuclease-1
References (Earliest) J:22846 Peitsch MC, et al., Genomic organisation and expression of mouse deoxyribonuclease I. Biochem Biophys Res Commun. 1995 Feb 6;207(1):62-8
(Latest) J:209292 Rossaint J, et al., Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation. Blood. 2014 Apr 17;123(16):2573-84
All references(44)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-24023, MGI:2146484

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory