Phenotypes Associated with This Genotype

Genotype
MGI:6400352

• Allelic Composition: Dnase1^tm2092.1Arte/Dnase1^tm2092.1Arte
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to systemic lupus erythematosus ( J:277126 )

• mice spontaneously develop a systemic lupus erythematosus-like disease with elevated autoantibody production by 9 months and kidney damage by 12 months of age

increased autoantibody level ( J:277126 )

• mice show increased anti-sM autoantibodies, with females showing higher levels than males

increased anti-nuclear antigen antibody level ( J:277126 )

• mice show increased levels of anti-nuclear antibodies in the blood at 9 months of age

• mice show increased levels of anti-nucleosome antibodies at 9 months of age, with females producing higher levels than males

increased anti-double stranded DNA antibody level ( J:277126 )

• females show an increase in anti-dsDNA autoantibodies in the circulation

increased anti-histone antibody level ( J:277126 )

• males show an increase in anti-histone antibodies in the circulation

glomerulonephritis ( J:277126 )

• 80% of females and 60% of males exhibit glomerulonephritis at 12 months of age compared to 32% and 16% of wild-type females and males, respectively

• mice with glomerulonephritis show deposition of IgG and C3 in glomeruli

renal/urinary system

abnormal kidney morphology ( J:277126 )

• 12 month old mice exhibit kidney damage, showing accumulation of immune cells around blood vessels (perivascular infiltration), damaged glomerulus, and immune complex deposition in kidneys

• females show more severely damaged kidneys than males

glomerulonephritis ( J:277126 )

• 80% of females and 60% of males exhibit glomerulonephritis at 12 months of age compared to 32% and 16% of wild-type females and males, respectively

• mice with glomerulonephritis show deposition of IgG and C3 in glomeruli

homeostasis/metabolism

increased circulating creatinine level ( J:277126 )

• serum creatinine levels are increased in 12 month old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:277126