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Atrx Gene Detail
Summary
  • Symbol
    Atrx
  • Name
    ATRX, chromatin remodeler
  • Synonyms
    4833408C14Rik, alpha thalassemia/mental retardation syndrome X-linked, DXHXS6677E, Hp1bp2, HP1-BP38, Rad54, XH2, Xnp
  • Feature Type
    protein coding gene
  • IDs
    MGI:103067
    NCBI Gene: 22589
  • Gene Overview
    MyGene.info: ATRX
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    ChrX:105797615-105929403 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      131789 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 47.26 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ATRX, ATRX, chromatin remodeler
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATRX, ATRX, chromatin remodeler
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JMS, MRX52, RAD54, RAD54L, XH2, XNP, ZNF-HX
  • Links
    NCBI Gene ID: 546
    neXtProt AC: NX_P46100
    UniProt: P46100

  • Chr Location
    Xq21.1; chrX:77504878-77786269 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 416
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ATRX
  • Gene Tree
    Atrx
Human Diseases
more
  • Diseases
    1 with Atrx mouse models; 1 with human ATRX associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 5 alleles in 6 genetic backgrounds
    10 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a floxed allele activated in different tissues at different time points can serve as a model of alpha-thalassemia/mental retardation syndrome, nondeletion type, X-linked.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    229
  • Tissues
    203
  • cDNA Data
    35
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000018268 VEGA Gene Model | MGI Sequence Detail 131789 C57BL/6J ±  kb
    transcript OTTMUST00000044133 VEGA | MGI Sequence Detail 10275 Not Applicable  
    polypeptide OTTMUSP00000019840 VEGA | MGI Sequence Detail 2476 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      384 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 2
      cDNA 37
      Primer pair 2

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGD-MRK-16212, MGD-MRK-18764, MGD-MRK-23929, MGD-MRK-38415, MGI:109370, MGI:1914653, MGI:2147885
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 23
      Diseases 2
      Gene Ontology 20
      Phenotypes 31
    • Earliest
      J:16603 Gecz J, et al., Cloning and expression of the murine homologue of a putative human X-linked nuclear protein gene closely linked to PGK1 in Xq13.3. Hum Mol Genet. 1994 Jan;3(1):39-44
    • Latest
      J:260738 Danussi C, et al., Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nat Commun. 2018 Mar 13;9(1):1057
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/16/2018
    MGI 6.12     		The Jackson Laboratory