Gene Expression Literature Summary

• Symbol: Atrx
• Name: ATRX, chromatin remodeler
• ID: MGI:103067

30 matching records from 30 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E6.5	E7	E7.5	E8	E8.5	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14.5	E15.5	E16	E16.5	E17	E17.5	E	P
Immunohistochemistry (section)	3	2			1			1	1		1				1		1		4	2	3		1		2		10
In situ RNA (section)		1	1	1	1	1	2	2	2	2					1	1		1		1		1		1			1
Immunohistochemistry (whole mount)	1	1	1		1
In situ RNA (whole mount)		1					1		1				1	1	1		1		1	1	2		1
Western blot																	1		1	1	2						6
RT-PCR		1			1		1					1	2						1				1		1		6
cDNA clones																										1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Atrx  ATRX, chromatin remodeler   (Synonyms: 4833408C14Rik, alpha thalassemia/mental retardation syndrome X-linked, DXHXS6677E, Hp1bp2, HP1-BP38, Rad54, XH2, Xnp)
Results	Reference
1	J:225216 Alvarez-Saavedra M, De Repentigny Y, Lagali PS, Raghu Ram EV, Yan K, Hashem E, Ivanochko D, Huh MS, Yang D, Mears AJ, Todd MA, Corcoran CP, Bassett EA, Tokarew NJ, Kokavec J, Majumder R, Ioshikhes I, Wallace VA, Kothary R, Meshorer E, Stopka T, Skoultchi AI, Picketts DJ, Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation. Nat Commun. 2014;5:4181
3	J:269736 Ancelin K, Syx L, Borensztein M, Ranisavljevic N, Vassilev I, Briseno-Roa L, Liu T, Metzger E, Servant N, Barillot E, Chen CJ, Schule R, Heard E, Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation. Elife. 2016 Feb 2;5:e08851
4	J:171630 Bagheri-Fam S, Argentaro A, Svingen T, Combes AN, Sinclair AH, Koopman P, Harley VR, Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome. Hum Mol Genet. 2011 Jun 1;20(11):2213-24
5	J:95953 Berube NG, Mangelsdorf M, Jagla M, Vanderluit J, Garrick D, Gibbons RJ, Higgs DR, Slack RS, Picketts DJ, The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. J Clin Invest. 2005 Feb;115(2):258-67
3*	J:301026 Bogolyubova IO, Sailau ZK, Bogolyubov DS, The dynamics of DAXX protein distribution in the nucleus of mouse early embryos. Acta Histochem. 2019 May;121(4):522-529
5*	J:194052 Corbel C, Diabangouaya P, Gendrel AV, Chow JC, Heard E, Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells. Development. 2013 Feb;140(4):861-72
4*	J:115836 Garrick D, Sharpe JA, Arkell R, Dobbie L, Smith AJ, Wood WG, Higgs DR, Gibbons RJ, Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues. PLoS Genet. 2006 Apr;2(4):e58
2	J:204566 Gendrel AV, Tang YA, Suzuki M, Godwin J, Nesterova TB, Greally JM, Heard E, Brockdorff N, Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Mol Cell Biol. 2013 Aug;33(16):3150-65
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:341518 Guthmann M, Qian C, Gialdini I, Nakatani T, Ettinger A, Schauer T, Kukhtevich I, Schneider R, Lamb DC, Burton A, Torres-Padilla ME, A change in biophysical properties accompanies heterochromatin formation in mouse embryos. Genes Dev. 2023 Apr 1;37(7-8):336-350
4	J:316683 Huh MS, Ivanochko D, Hashem LE, Curtin M, Delorme M, Goodall E, Yan K, Picketts DJ, Stalled replication forks within heterochromatin require ATRX for protection. Cell Death Dis. 2016 May 12;7:e2220
11*	J:173600 Huyhn K, Renfree MB, Graves JA, Pask AJ, ATRX has a critical and conserved role in mammalian sexual differentiation. BMC Dev Biol. 2011;11:39
6	J:150959 Kalantry S, Purushothaman S, Bowen RB, Starmer J, Magnuson T, Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation. Nature. 2009 Jul 30;460(7255):647-51
3	J:158584 Kernohan KD, Jiang Y, Tremblay DC, Bonvissuto AC, Eubanks JH, Mann MR, Berube NG, ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain. Dev Cell. 2010 Feb 16;18(2):191-202
1	J:37212 Le Douarin B, Nielsen AL, Garnier JM, Ichinose H, Jeanmougin F, Losson R, Chambon P, A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J. 1996 Dec 2;15(23):6701-15
1	J:312431 Matsuura R, Nakajima T, Ichihara S, Sado T, Ectopic Splicing Disturbs the Function of Xist RNA to Establish the Stable Heterochromatin State. Front Cell Dev Biol. 2021;9:751154
5	J:145002 Medina CF, Mazerolle C, Wang Y, Berube NG, Coupland S, Gibbons RJ, Wallace VA, Picketts DJ, Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome. Hum Mol Genet. 2009 Mar 1;18(5):966-77
4	J:188393 Michod D, Bartesaghi S, Khelifi A, Bellodi C, Berliocchi L, Nicotera P, Salomoni P, Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation. Neuron. 2012 Apr 12;74(1):122-35
1	J:185555 Mugford JW, Yee D, Magnuson T, Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation. Development. 2012 Jun;139(12):2130-8
1*	J:150963 Pavlinkova G, Salbaum JM, Kappen C, Maternal diabetes alters transcriptional programs in the developing embryo. BMC Genomics. 2009;10:274
1*	J:86824 Payer B, Saitou M, Barton SC, Thresher R, Dixon JP, Zahn D, Colledge WH, Carlton MB, Nakano T, Surani MA, stella is a maternal effect gene required for normal early development in mice. Curr Biol. 2003 Dec 2;13(23):2110-7
4*	J:239322 Sailau ZK, Bogolyubov DS, Bogolyubova IO, Nuclear distribution of the chromatin-remodeling protein ATRX in mouse early embryogenesis. Acta Histochem. 2017 Jan;119(1):18-25
1	J:266555 Sakakibara Y, Nagao K, Blewitt M, Sasaki H, Obuse C, Sado T, Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice. Development. 2018 Sep 25;145(18):dev166462
1	J:243417 Sakata Y, Nagao K, Hoki Y, Sasaki H, Obuse C, Sado T, Defects in dosage compensation impact global gene regulation in the mouse trophoblast. Development. 2017 Aug 01;144(15):2784-2797
2*	J:227628 Sarkar MK, Gayen S, Kumar S, Maclary E, Buttigieg E, Hinten M, Kumari A, Harris C, Sado T, Kalantry S, An Xist-activating antisense RNA required for X-chromosome inactivation. Nat Commun. 2015;6:8564
4	J:142359 Seah C, Levy MA, Jiang Y, Mokhtarzada S, Higgs DR, Gibbons RJ, Berube NG, Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53. J Neurosci. 2008 Nov 19;28(47):12570-80
3	J:203136 Solomon LA, Russell BA, Watson LA, Beier F, Berube NG, Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly. Hum Mol Genet. 2013 Dec 15;22(24):5015-25
8*	J:21528 Stayton CL, Dabovic B, Gulisano M, Gecz J, Broccoli V, Giovanazzi S, Bossolasco M, Monaco L, Rastan S, Boncinelli E, Bianchi ME, Cloning and characterization of a new human Xq13 gene, encoding a putative helicase. Hum Mol Genet. 1994 Nov;3(11):1957-64
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
4	J:201463 Watson LA, Solomon LA, Li JR, Jiang Y, Edwards M, Shin-ya K, Beier F, Berube NG, Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest. 2013 May 1;123(5):2049-63