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Stat4 Gene Detail
Summary
  • Symbol
    Stat4
  • Name
    signal transducer and activator of transcription 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:103062
    NCBI Gene: 20849
  • Gene Overview
    MyGene.info: STAT4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:51987148-52107189 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      120042 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 26.67 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    STAT4, signal transducer and activator of transcription 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STAT4, signal transducer and activator of transcription 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SLEB11
  • Links
    NCBI Gene ID: 6775
    neXtProt AC: NX_Q14765
    UniProt: Q14765

  • Chr Location
    2q32.2-q32.3; chr2:191029576-191172684 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Stat4 mouse models; 1 with human STAT4 associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 7 genetic backgrounds
    8 phenotypes from multigenic genotypes
    187 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to altered cytokine production of T-cells, impaired IL-12 responses, enhanced Th2 cell development, decreased susceptibility to autoimmune diabetes, altered NK cell responses during viral infection, and increased susceptibility to Salmonella infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000046732 VEGA Gene Model | MGI Sequence Detail 120042 C57BL/6J ±  kb
    transcript OTTMUST00000121356 VEGA | MGI Sequence Detail 2662 Not Applicable  
    polypeptide OTTMUSP00000066904 VEGA | MGI Sequence Detail 748 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1129 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • PDB
    • InterPro Domains
      IPR008967 p53-like transcription factor, DNA-binding
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
      IPR029839 Signal transducer and activator of transcription 4
      IPR035856 STAT4, SH2 domain
      IPR013800 STAT transcription factor, all-alpha domain
      IPR015988 STAT transcription factor, coiled coil
      IPR013801 STAT transcription factor, DNA-binding
      IPR012345 STAT transcription factor, DNA-binding, N-terminal
      IPR036535 STAT transcription factor, N-terminal domain superfamily
      IPR013799 STAT transcription factor, protein interaction
      IPR001217 Transcription factor STAT
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 40
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23924
    References
    more
    • Summaries
      All 268
      Developmental Gene Expression 8
      Diseases 3
      Gene Ontology 14
      Phenotypes 187
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:251269 Taghavie-Moghadam PL, et al., STAT4 Regulates the CD8(+) Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr(-/-) Mice. J Immunol. 2017 Nov 15;199(10):3453-3465

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory