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Stat4 Gene Detail
Summary
  • Symbol
    Stat4
  • Name
    signal transducer and activator of transcription 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:103062
    NCBI Gene: 20849
  • Gene Overview
    MyGene.info: STAT4
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:51987148-52107189 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 26.67 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1129 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103062
protein coding gene Chr1:51987106-52107189 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016005
protein coding gene Chr1:51489328-51615367 (+)
A/J MGP_AJ_G0015987
protein coding gene Chr1:49767891-49888040 (+)
AKR/J MGP_AKRJ_G0015943
protein coding gene Chr1:50813358-50940648 (+)
BALB/cJ MGP_BALBcJ_G0015944
protein coding gene Chr1:49579658-49702948 (+)
C3H/HeJ MGP_C3HHeJ_G0015776
protein coding gene Chr1:51217508-51346069 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016395
protein coding gene Chr1:53664175-53788748 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014129
protein coding gene Chr1:41969035-42087567 (-)
CAST/EiJ MGP_CASTEiJ_G0015357
protein coding gene Chr1:50694650-50824019 (+)
CBA/J MGP_CBAJ_G0015747
protein coding gene Chr1:55086923-55219958 (+)
DBA/2J MGP_DBA2J_G0015848
protein coding gene Chr1:49020524-49139372 (+)
FVB/NJ MGP_FVBNJ_G0015850
protein coding gene Chr1:48486030-48604398 (+)
LP/J MGP_LPJ_G0015919
protein coding gene Chr1:51972149-52112981 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015870
protein coding gene Chr1:58117357-58249472 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016443
protein coding gene Chr1:50944377-51070511 (+)
PWK/PhJ MGP_PWKPhJ_G0015143
protein coding gene Chr1:48898082-49020483 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014923
protein coding gene Chr1:50599081-50725288 (+)
WSB/EiJ MGP_WSBEiJ_G0015420
protein coding gene Chr1:50758577-50883154 (+)



Homology
more
  • Human Ortholog
    STAT4, signal transducer and activator of transcription 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STAT4, signal transducer and activator of transcription 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SLEB11
  • Links
    NCBI Gene ID: 6775
    neXtProt AC: NX_Q14765
    UniProt: Q14765

  • Chr Location
    2q32.2-q32.3; chr2:191029576-191172684 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Stat4 mouse models; 1 with human STAT4 associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 7 genetic backgrounds
    8 phenotypes from multigenic genotypes
    188 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to altered cytokine production of T-cells, impaired IL-12 responses, enhanced Th2 cell development, decreased susceptibility to autoimmune diabetes, altered NK cell responses during viral infection, and increased susceptibility to Salmonella infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062939 Ensembl Gene Model | MGI Sequence Detail 120042 C57BL/6J ±  kb
    transcript ENSMUST00000168302 Ensembl | MGI Sequence Detail 2662 Not Applicable  
    polypeptide ENSMUSP00000130713 Ensembl | MGI Sequence Detail 748 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • PDB
    • InterPro Domains
      IPR008967 p53-like transcription factor, DNA-binding
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
      IPR029839 Signal transducer and activator of transcription 4
      IPR035856 STAT4, SH2 domain
      IPR013800 STAT transcription factor, all-alpha domain
      IPR015988 STAT transcription factor, coiled coil
      IPR013801 STAT transcription factor, DNA-binding
      IPR012345 STAT transcription factor, DNA-binding, N-terminal
      IPR036535 STAT transcription factor, N-terminal domain superfamily
      IPR013799 STAT transcription factor, protein interaction
      IPR001217 Transcription factor STAT
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 41
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23924
    References
    more
    • Summaries
      All 270
      Developmental Gene Expression 9
      Diseases 3
      Gene Ontology 14
      Phenotypes 188
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:265084 Mikami Y, et al., NCR(+) ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice. Eur J Immunol. 2018 Jul;48(7):1174-1180

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory