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Stat4 Gene Detail
Summary
  • Symbol
    Stat4
  • Name
    signal transducer and activator of transcription 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:103062
    NCBI Gene: 20849
  • Gene Overview
    MyGene.info: STAT4
Location & Maps
more
  • Sequence Map
    Chr1:51987148-52107189 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      120042 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 26.67 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    STAT4, signal transducer and activator of transcription 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STAT4, signal transducer and activator of transcription 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SLEB11
  • Links
    NCBI Gene ID: 6775
    neXtProt AC: NX_Q14765

  • Chr Location
    2q32.2-q32.3; chr2:191029576-191246172 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Stat4 mouse models; 1 with human STAT4 associations

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100 View 4 models
       Systemic Lupus Erythematosus, Susceptibility to, 11; SLEB11   OMIM: 612253
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 7 genetic backgrounds
    8 phenotypes from multigenic genotypes
    181 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Stat4
  • Incidental Mutations
Homozygous inactivation of this gene leads to altered cytokine production of T-cells, impaired IL-12 responses, enhanced Th2 cell development, decreased susceptibility to autoimmune diabetes, altered NK cell responses during viral infection, and increased susceptibility to Salmonella infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046732 VEGA Gene Model | MGI Sequence Detail 120042 C57BL/6J ±  kb
transcript OTTMUST00000121356 VEGA | MGI Sequence Detail 2662 Not Applicable  
polypeptide OTTMUSP00000066904 VEGA | MGI Sequence Detail 748 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1129 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000002090 signal transducer and activator of transcription 4
  • PDB
  • InterPro Domains
    IPR011992 EF-hand domain pair
    IPR008967 p53-like transcription factor, DNA-binding
    IPR000980 SH2 domain
    IPR029839 Signal transducer and activator of transcription 4
    IPR013800 STAT transcription factor, all-alpha domain
    IPR015988 STAT transcription factor, coiled coil
    IPR013801 STAT transcription factor, DNA-binding
    IPR012345 STAT transcription factor, DNA-binding, subdomain
    IPR013799 STAT transcription factor, protein interaction
    IPR001217 Transcription factor STAT
Molecular
Reagents
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  • All nucleic 42
    cDNA 40
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-23924
References
more
  • Summaries
    All 244
    Developmental Gene Expression 8
    Diseases 3
    Gene Ontology 11
    Phenotypes 181
  • Earliest
    J:18621 Zhong Z, et al., Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4806-10
  • Latest
    J:223378 Harbour SN, et al., Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis. Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7061-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory