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Stat4
Gene Detail
Symbol

Name
ID
Stat4
signal transducer and activator of transcription 4
MGI:103062
Feature Type
protein coding gene
Genetic Map
Chromosome 1
26.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:51987148-52107189 bp, + strand
From VEGA annotation of GRCm38

  120042 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20679  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: signal transducer and transcription activator STAT5A
Gene Tree: Stat4

Human
homologs
Human Homolog STAT4, signal transducer and activator of transcription 4
NCBI Gene ID 6775
neXtProt AC  NX_Q14765
Human Synonyms  SLEB11
Human Chr (Location)  2q32.2-q32.3; chr2:191029576-191172671 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human STAT4
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Chemically induced (ENU)(1) Gene trapped(10) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to altered cytokine production of T-cells, impaired IL-12 responses, enhanced Th2 cell development, decreased susceptibility to autoimmune diabetes, altered NK cell responses during viral infection, and increased susceptibility to Salmonella infection.
 
Human Diseases Modeled Using Mouse Stat4 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Stat4 interacts with 50 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell proliferation, cellular response to organic substance, ...
Component cytoplasm, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (130)    Tissues (62)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 86
RT-PCR 44
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) cDNA(40) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000046732 (Evidence)
Ensembl Gene ModelENSMUSG00000062939 (Evidence)
Entrez Gene20849 (Evidence)
UniGene1550
DFCITC1579531, TC1616768
DoTSDT.110921457, DT.50315592, DT.91558281
NIA Mouse Gene IndexU000262
PDB1BGF
Consensus CDS ProjectCCDS14943.1
International Mouse Knockout Project StatusStat4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046732 VEGA Gene Model | MGI Sequence Detail 120042 C57BL/6J ±  kb
transcript OTTMUST00000121357 VEGA | MGI Sequence Detail 2982 Not Applicable 
polypeptide OTTMUSP00000066905 VEGA | MGI Sequence Detail 748 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(1138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011992 EF-hand-like domain
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR000980 SH2 domain
InterPro IPR013800 STAT transcription factor, all-alpha
InterPro IPR015988 STAT transcription factor, coiled coil
InterPro IPR001217 STAT transcription factor, core
InterPro IPR013801 STAT transcription factor, DNA-binding
InterPro IPR012345 STAT transcription factor, DNA-binding, subdomain
InterPro IPR013799 STAT transcription factor, protein interaction
Protein Ontology PR:000002090 signal transducer and activator of transcription 4
References
(Earliest) J:18621 Zhong Z, et al., Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4806-10
(Latest) J:211092 Wang Y, et al., STAT4 knockout mice are more susceptible to concanavalin A-induced T-cell hepatitis. Am J Pathol. 2014 Jun;184(6):1785-94
All references(245)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-23924

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory