Stat4
Gene Detail

Symbol Name ID

Stat4 signal transducer and activator of transcription 4 MGI:103062

Feature Type

protein coding gene

Genetic Map

Chromosome 1

26.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr1:52008244-52107184 bp, + strand From NCBI annotation of GRCm38   98941 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20679  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: signal transducer and transcription activator STAT5A
Gene Tree: Stat4

Human homologs

Human Homolog		STAT4, signal transducer and activator of transcription 4
NCBI Gene ID		6775
neXtProt AC		NX_Q14765
Human Synonyms		SLEB11
Human Chr (Location)		2q32.2-q32.3; chr2:191894302-192016322 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human STAT4

Alleles and phenotypes

All alleles(14) : Targeted(4) Gene trapped(10)
 

Homozygous inactivation of this gene leads to altered cytokine production of T-cells, impaired IL-12 responses, enhanced Th2 cell development, decreased susceptibility to autoimmune diabetes, altered NK cell responses during viral infection, and increased susceptibility to Salmonella infection.

 
Human Diseases Modeled Using Mouse Stat4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell proliferation, cellular response to organic substance, ...
Component	cytoplasm, nucleus
Function	calcium ion binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (137)    Tissues (66)    Images (21)
Theiler Stages: 2, 3, 4, 5, 17, 21, 23, 28

Assay Type	Results
RNA in situ	86
RT-PCR	51

cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) cDNA(40) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000062939 (Evidence)
Entrez Gene	20849 (Evidence)
UniGene	1550
DFCI	TC1579531, TC1616768
DoTS	DT.110921457, DT.50315592, DT.91558281
NIA Mouse Gene Index	U000262
PDB	1BGF
Consensus CDS Project	CCDS14943.1
International Mouse Knockout Project Status	Stat4

Sequences

Length	Strain/Species
genomic	20849	NCBI Gene Model | MGI Sequence Detail	98941	C57BL/6J
transcript	NM_011487	RefSeq | MGI Sequence Detail	2981	C57BL/6
polypeptide	P42228	UniProt | EBI | MGI Sequence Detail	749	Not Applicable

All sequences(28) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(621 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR000980	SH2 domain
InterPro	IPR013800	STAT transcription factor, all-alpha
InterPro	IPR015988	STAT transcription factor, coiled coil
InterPro	IPR001217	STAT transcription factor, core
InterPro	IPR013801	STAT transcription factor, DNA-binding
InterPro	IPR012345	STAT transcription factor, DNA-binding, subdomain
InterPro	IPR013799	STAT transcription factor, protein interaction
Protein Ontology	PR:000002090	signal transducer and activator of transcription 4

Graphical View of Protein Domain Structure

References

(Earliest) J:18621 Zhong Z, et al., Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4806-10
(Latest) J:194747 Bell BD, et al., The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol. 2013 Apr;14(4):364-71
All references(226)

Other accession IDs

MGD-MRK-23924