Automated description from the Alliance of Genome Resources (Release 9.0.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; protein phosphorylation; and regulation of gene expression. Is active in cytoplasm and nucleus. Is expressed in several structures, including 2-cell stage conceptus; 4-cell stage embryo; axial skeleton; cranium; and genitourinary system. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; autoimmune disease of musculoskeletal system (multiple); liver disease (multiple); myositis (multiple); and scleroderma (multiple). Orthologous to human STAT4 (signal transducer and activator of transcription 4).
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