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Stat6
Gene Detail
Symbol

Name
ID
Stat6
signal transducer and activator of transcription 6
MGI:103034
Feature Type
protein coding gene
Genetic Map
Chromosome 10
74.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:127642986-127660957 bp, + strand
From VEGA annotation of GRCm38

  17972 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2373  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: signal transducer and transcription activator STAT5A
Gene Tree: Stat6

Human
homologs
Human Homolog STAT6, signal transducer and activator of transcription 6, interleukin-4 induced
NCBI Gene ID 6778
neXtProt AC  NX_P42226
Human Synonyms  D12S1644, IL-4-STAT, STAT6B, STAT6C
Human Chr (Location)  12q13; chr12:57095404-57111413 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired IL4 responses, including anti-IgM stimulated B cell proliferation, class switching to IgE, contact sensitivity, and Th2 cytokine production, and show increased resistance to certain infections.
 
Interactions
Stat6 interacts with 219 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cellular response to hydrogen peroxide, cellular response to reactive nitrogen species, ...
Component cytoplasm, membrane raft, ...
Function DNA binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (103)    Tissues (52)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 67
RT-PCR 36
cDNA source data(77)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(81) Genomic(2) cDNA(77) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031818 (Evidence)
Ensembl Gene ModelENSMUSG00000002147 (Evidence)
Entrez Gene20852 (Evidence)
UniGene121721
DFCITC1582237, TC1628199, TC1716056
Consensus CDS ProjectCCDS36082.1
International Mouse Knockout Project StatusStat6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031818 VEGA Gene Model | MGI Sequence Detail 17972 C57BL/6J ±  kb
transcript OTTMUST00000078897 VEGA | MGI Sequence Detail 3775 Not Applicable 
polypeptide OTTMUSP00000042008 VEGA | MGI Sequence Detail 837 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011992 EF-hand-like domain
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR000980 SH2 domain
InterPro IPR013800 STAT transcription factor, all-alpha
InterPro IPR015988 STAT transcription factor, coiled coil
InterPro IPR001217 STAT transcription factor, core
InterPro IPR013801 STAT transcription factor, DNA-binding
InterPro IPR012345 STAT transcription factor, DNA-binding, subdomain
InterPro IPR013799 STAT transcription factor, protein interaction
Protein Ontology PR:000002093 signal transducer and activator of transcription 6
References
(Earliest) J:25497 Quelle FW, et al., Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol Cell Biol. 1995 Jun;15(6):3336-43
(Latest) J:214773 Han NR, et al., TSLP induces mast cell development and aggravates allergic reactions through the activation of MDM2 and STAT6. J Invest Dermatol. 2014 Oct;134(10):2521-30
All references(434)
Other
accession IDs
MGD-MRK-23872

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory