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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Stat6
signal transducer and activator of transcription 6
MGI:103034
70 phenotypes from 3 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Stat6tm1Aki/Stat6tm1Aki
C.129P2-Stat6tm1Aki Nfkbiztm1Aki 		acanthosis J:141704
skin inflammation J:141704
Stat6tm1Aki/Stat6tm1Aki
involves: 129P2/OlaHsd 		abnormal T-helper 2 physiology J:32561
decreased B cell proliferation J:32561
decreased IgE level J:32561
decreased IgG1 level J:32561
decreased T cell proliferation J:32561
decreased T-helper 2 cell number J:172134
increased IgA level J:32561
increased IgG level J:32561
Stat6tm1Gru/Stat6tm1Gru
129S2/SvPas-Stat6tm1Gru 		abnormal interleukin secretion J:31932
abnormal T-helper 2 cell differentiation J:31932
decreased IgE level J:31932
decreased interleukin-4 secretion J:31932
decreased interleukin-5 secretion J:31932
decreased T cell proliferation J:31932
Stat6tm1Gru/Stat6tm1Gru
C.129S2-Stat6tm1Gru 		abnormal airway responsiveness J:66222, J:74497
abnormal circulating interleukin level J:66222
abnormal circulating interleukin-4 level J:66222
abnormal circulating interleukin-5 level J:66222
abnormal cytotoxic T cell physiology J:65894
abnormal immune serum protein physiology J:66222
abnormal immunoglobulin level J:66222
abnormal leukocyte migration J:74497
abnormal leukocyte physiology J:74497
abnormal noradrenaline level J:178294
abnormal renal tubule morphology J:84825
abnormal respiratory epithelium morphology J:66222, J:74497
abnormal tumor susceptibility J:65894
decreased core body temperature J:178294
decreased fatty acids level J:178294
decreased IgE level J:66222, J:74497
decreased IgG1 level J:66222
decreased metastatic potential J:65894
impaired eosinophil recruitment J:66222
increased circulating creatine level J:84825
increased IgG2a level J:66222
Stat6tm1Gru/Stat6tm1Gru
C.129S2-Stat6tm1Gru/J 		abnormal CD4-positive T cell differentiation J:204829
abnormal CD8-positive, alpha beta T cell morphology J:125259
abnormal humoral immune response J:107370
decreased IgA level J:107370
decreased IgG3 level J:107370
decreased IgM level J:107370
decreased interleukin-4 secretion J:107370
decreased susceptibility to Herpesvirales infection J:107370
increased interferon-gamma secretion J:107370
increased interleukin-2 secretion J:107370
Stat6tm1Gru/Stat6tm1Gru
involves: 129S2/SvPas 		abnormal cytokine secretion J:112600
abnormal mammary gland epithelium morphology J:184505
abnormal mammary gland growth during pregnancy J:184505
abnormal mammary gland morphology J:184505
decreased mammary gland epithelial cell proliferation J:184505
Stat6tm1Gru/Stat6tm1Gru
involves: 129S2/SvPas * BALB/c 		abnormal acute inflammation J:85386
abnormal circulating alanine transaminase level J:85386
abnormal granulocyte physiology J:85386
abnormal macrophage physiology J:85386
abnormal mammary gland growth during pregnancy J:124116
normal immune system phenotype J:85386
impaired eosinophil chemotaxis J:85386
impaired neutrophil chemotaxis J:85386
increased circulating tumor necrosis factor level J:85386
normal liver/biliary system phenotype J:85386
Stat6tm1Gru/Stat6tm1Gru
involves: 129S2/SvPas * C57BL/6 		decreased core body temperature J:178294
Stat6tm1Jni/Stat6tm1Jni
involves: 129S/SvEv 		abnormal B cell physiology J:32607
abnormal B cell proliferation J:32607
abnormal class switch recombination J:32607
abnormal level of surface class II molecules J:32607
abnormal T-helper 1 cell differentiation J:32607
abnormal T-helper 2 cell differentiation J:32607
increased B cell apoptosis J:146533
increased cellular sensitivity to gamma-irradiation J:146533
Stat6tm1Jni/Stat6tm1Jni
involves: 129S/SvEv * C57BL/6 		abnormal mast cell morphology J:110429
abnormal T-helper 1 cell differentiation J:51096
decreased IgE level J:51096
decreased IgG1 level J:51096
decreased interleukin-4 secretion J:96338
decreased susceptibility to autoimmune diabetes J:96338
increased IgE level J:110429
increased IgG1 level J:110429
increased IgG2a level J:51096
increased interferon-gamma secretion J:51096, J:96338
increased interleukin-12 secretion J:51096
increased susceptibility to parasitic infection J:110429
skin lesions J:51096
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory