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Foxn1
Gene Detail
 Symbol
Name
ID
Foxn1
forkhead box N1
MGI:102949
Synonyms D11Bhm185e, Hfh11, whn
Feature Type protein coding gene
Genetic Map
Chromosome 11
46.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr11:78357577-78386558 bp, - strand
From VEGA annotation of GRCm38

  28982 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Foxn1

Human
homologs
Human Homolog FOXN1, forkhead box N1
NCBI Gene ID 8456
neXtProt AC  NX_O15353
Human Synonyms  FKHL20, RONU, WHN
Human Chr (Location)  17q11-q12; chr17:28506260-28538157 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FOXN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(4) Spontaneous(7) Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for different mutations have in genetically determined absence or loss of hair and failed hair keratinization, premature lethality (differing by genetic background) and absence of thymus, resulting in multiple immune abnormalities. Heterozygotes have enlarged thymuses.
 
Human Diseases Modeled Using Mouse Foxn1 (2)    Alleles Annotated to Human Diseases(3)    Phenotype Images(6)
Interactions
Foxn1 interacts with 214 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell proliferation, embryo development, ...
Component nucleus
Function DNA binding, DNA binding, bending, ...
External Resources: FuncBase
Expression
Literature Summary: (43 records)
Data Summary: Results (165)    Tissues (81)    Images (52)
Theiler Stages: 12, 14, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 94
In situ reporter (knock in) 3
Northern blot 12
Western blot 6
RT-PCR 40
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) Genomic(18) cDNA(15) Primer pair(7) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000000142 (Evidence)
Ensembl Gene ModelENSMUSG00000002057 (Evidence)
Entrez Gene15218 (Evidence)
DFCITC1589791, TC1712018, TC1725890
DoTSDT.524482
NIA Mouse Gene IndexU033130
Consensus CDS ProjectCCDS25102.1
International Mouse Knockout Project StatusFoxn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000142 VEGA Gene Model | MGI Sequence Detail 28982 C57BL/6J ±  kb
transcript OTTMUST00000000457 VEGA | MGI Sequence Detail 3214 Not Applicable 
polypeptide OTTMUSP00000000197 VEGA | MGI Sequence Detail 648 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(14) UniProt(3)
Polymorphisms PCR(3) : SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007636 forkhead box protein N1
References (Earliest) J:2484 Truslove GM, Genetical studies on the skeleton of the mouse. V. 'Interfrontal' and 'parted frontals'. J Genet. 1952;51:115-122
(Latest) J:210245 Huang W, et al., Dendritic cell-MHC class II and Itk regulate functional development of regulatory innate memory CD4+ T cells in bone marrow transplantation. J Immunol. 2014 Apr 1;192(7):3435-41
All references(526)
Disease annotation references (7)
Other
accession IDs
MGD-MRK-12946, MGD-MRK-23783, MGD-MRK-35270, MGI:106810

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory