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Foxn1 Gene Detail
Summary
  • Symbol
    Foxn1
  • Name
    forkhead box N1
  • Synonyms
    D11Bhm185e, Hfh11, whn
  • Feature Type
    protein coding gene
  • IDs
    MGI:102949
    NCBI Gene: 15218
  • Gene Overview
    MyGene.info: FOXN1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78357577-78386558 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102949
protein coding gene Chr11:78357577-78387654 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018778
protein coding gene Chr11:79360724-79391427 (-)
A/J MGP_AJ_G0018744
protein coding gene Chr11:76320833-76354388 (-)
AKR/J MGP_AKRJ_G0018714
protein coding gene Chr11:78626394-78656772 (-)
BALB/cJ MGP_BALBcJ_G0018718
protein coding gene Chr11:76730440-76759728 (-)
C3H/HeJ MGP_C3HHeJ_G0018531
protein coding gene Chr11:78675517-78705409 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019169
protein coding gene Chr11:81830796-81859749 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016804
protein coding gene Chr11:73298666-73327563 (-)
CAST/EiJ MGP_CASTEiJ_G0018085
protein coding gene Chr11:79124245-79155037 (-)
CBA/J MGP_CBAJ_G0018501
protein coding gene Chr11:85415323-85429727 (-)
DBA/2J MGP_DBA2J_G0018610
protein coding gene Chr11:75901481-75930507 (-)
FVB/NJ MGP_FVBNJ_G0018600
protein coding gene Chr11:75487454-75517212 (-)
LP/J MGP_LPJ_G0018681
protein coding gene Chr11:79889198-79918052 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018626
protein coding gene Chr11:85813074-85842082 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019209
protein coding gene Chr11:78875476-78904492 (-)
PWK/PhJ MGP_PWKPhJ_G0017856
protein coding gene Chr11:76694030-76723688 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017647
protein coding gene Chr11:78486459-78515292 (-)
WSB/EiJ MGP_WSBEiJ_G0018138
protein coding gene Chr11:78701741-78733368 (-)



Homology
more
  • Human Ortholog
    FOXN1, forkhead box N1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FOXN1, forkhead box N1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKHL20, RONU, WHN
  • Links
    NCBI Gene ID: 8456
    neXtProt AC: NX_O15353
    UniProt: O15353

  • Chr Location
    17q11.2; chr17:28506211-28538900 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2664
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FOXN1
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Foxn1 mouse models; 1 with human FOXN1 associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    158 phenotypes from 21 alleles in 35 genetic backgrounds
    48 phenotypes from multigenic genotypes
    6 images
    475 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for different mutations have in genetically determined absence or loss of hair and failed hair keratinization, premature lethality (differing by genetic background) and absence of thymus, resulting in multiple immune abnormalities. Heterozygotes have enlarged thymuses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002057 Ensembl Gene Model | MGI Sequence Detail 28982 C57BL/6J ±  kb
    transcript ENSMUST00000108294 Ensembl | MGI Sequence Detail 3214 Not Applicable  
    polypeptide ENSMUSP00000103929 Ensembl | MGI Sequence Detail 648 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 19
      cDNA 15
      Primer pair 7
      Other 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12946, MGD-MRK-23783, MGD-MRK-35270, MGI:106810
    References
    more
    • Summaries
      All 620
      Developmental Gene Expression 53
      Diseases 5
      Gene Ontology 13
      Phenotypes 475
    • Earliest
      J:2484 Truslove GM, Genetical studies on the skeleton of the mouse. V. 'Interfrontal' and 'parted frontals'. J Genet. 1952;51:115-122
    • Latest
      J:265297 Miller CN, et al., Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development. Nature. 2018 Jul;559(7715):627-631

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory