Foxn1
Gene Detail

Symbol Name ID

Foxn1 forkhead box N1 MGI:102949

Synonyms

D11Bhm185e, Hfh11, whn

Feature Type

protein coding gene

Genetic Map

Chromosome 11

46.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)

Sequence Map

Chr11:78357577-78386558 bp, - strand From VEGA annotation of GRCm38   28982 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Foxn1

Human homologs

Human Homolog		FOXN1, forkhead box N1
NCBI Gene ID		8456
neXtProt AC		NX_O15353
Human Synonyms		FKHL20, RONU, WHN
Human Chr (Location)		17q11-q12; chr17:26850959-26865175 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FOXN1

Alleles and phenotypes

All alleles(24) : Targeted(13) Gene trapped(4) Spontaneous(7)
 

Homozygotes for different mutations have in genetically determined absence or loss of hair and failed hair keratinization, premature lethality (differing by genetic background) and absence of thymus, resulting in multiple immune abnormalities. Heterozygotes have enlarged thymuses.

 
Human Diseases Modeled Using Mouse Foxn1 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	cell proliferation, embryo development, ...
Component	nucleus, transcription factor complex
Function	DNA binding, DNA binding, bending, ...

External Resources: FuncBase

Expression

Literature Summary: (43 records)
Data Summary: Results (162)    Tissues (81)    Images (49)
Theiler Stages: 12, 14, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	91
In situ reporter (knock in)	3
Northern blot	12
Western blot	6
RT-PCR	40

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) Genomic(18) cDNA(15) Primer pair(7) Other(4)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000000142 (Evidence)
Ensembl Gene Model	ENSMUSG00000002057 (Evidence)
Entrez Gene	15218 (Evidence)
DFCI	TC1589791, TC1712018, TC1725890
DoTS	DT.524482
NIA Mouse Gene Index	U033130
Consensus CDS Project	CCDS25102.1
International Mouse Knockout Project Status	Foxn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000142	VEGA Gene Model | MGI Sequence Detail	28982	C57BL/6J
transcript	OTTMUST00000000457	VEGA | MGI Sequence Detail	3214	Not Applicable
polypeptide	OTTMUSP00000000197	VEGA | MGI Sequence Detail	648	Not Applicable

All sequences(30) RefSeq(4) UniProt(3)

Polymorphisms

PCR(3) : SNPs(12 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000007636	forkhead box protein N1

References

(Earliest) J:2484 Truslove GM, Genetical studies on the skeleton of the mouse. V. 'Interfrontal' and 'parted frontals'. J Genet. 1952;51:115-122
(Latest) J:195507 Seeley EJ, et al., Noradrenergic Neurons Regulate Monocyte Trafficking and Mortality during Gram-Negative Peritonitis in Mice. J Immunol. 2013 May 1;190(9):4717-24
All references(463)

Other accession IDs

MGD-MRK-12946, MGD-MRK-23783, MGD-MRK-35270, MGI:106810