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Phenotypes Associated with This Genotype
Genotype
MGI:2680668
Allelic
Composition
Foxn1nu/Foxn1nu
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (106 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 100% mortality by 25 weeks (J:5043)
• most die within a few weeks of weaning (J:30772)
• some mice die within 1 week of birth
• 55% mortality within 2 weeks

endocrine/exocrine glands
• a much smaller and dorsoventrally flattened thymic rudiment is present at E14-E15
• a thymic rudiment comprised of vesicles and lacking lymphoid cells is present at P1-P2

growth/size/body

liver/biliary system
• liver lobes were atrophied and covered with red scars
• variable degrees of severity, typically increasing with age at time of death

reproductive system
• many sperm had coiled tails
• many females exhibited continuous dioestrus and metaoestrus phases
• severely reduced fertility

immune system
• a much smaller and dorsoventrally flattened thymic rudiment is present at E14-E15
• a thymic rudiment comprised of vesicles and lacking lymphoid cells is present at P1-P2
• the proportion of red to white pulp is greater than normal
• in some cases the Malpighian follicles are present but are fewer in number and smaller than in controls
• in some cases an unusually high number of megakaryocytes is seen in the red pulp
• virtual absence of small lymphocytes in the thymus dependent area and the post-capillary venules are often thin walled and empty

integument
• sparse hair growth around 5 weeks of age (J:5043)
• in some mice, cephalo-caudal migration of an irregular band of short sparse hair (J:5043)
• mice fail to grow a first coat of hair (J:30772)
• absent at birth
• older mice show repeated growth and loss of short and wavy vibrissae
• older mice show repeated growth and loss of short and wavy vibrissae
• reduction in skin thickness at 3 weeks of age, corresponding to the catagen stage of normal skin

behavior/neurological
• longer latency during the acquisition and reversal phases in a Morris water maze
• in the extinction phase spend more time in the training quadrant and are less able to recall data from the previous day's training
• replenishing mice with T cells from wild-type mice improves performance in a Morris water maze

cardiovascular system
• in the thymus dependent area of the lymph nodes the post-capillary venules are often thin walled and empty

hematopoietic system
• a much smaller and dorsoventrally flattened thymic rudiment is present at E14-E15
• a thymic rudiment comprised of vesicles and lacking lymphoid cells is present at P1-P2
• the proportion of red to white pulp is greater than normal
• in some cases the Malpighian follicles are present but are fewer in number and smaller than in controls
• in some cases an unusually high number of megakaryocytes is seen in the red pulp

cellular
• many sperm had coiled tails


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory