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Pdx1 Gene Detail
Summary
  • Symbol
    Pdx1
  • Name
    pancreatic and duodenal homeobox 1
  • Synonyms
    IDX-1, Ipf1, IPF-1, Mody4, pdx-1, STF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102851
    NCBI Gene: 18609
  • Gene Overview
    MyGene.info: PDX1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:147270131-147275149 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 86.84 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102851
protein coding gene Chr5:147269959-147275848 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030386
protein coding gene Chr5:152913263-152919116 (+)
A/J MGP_AJ_G0030359
protein coding gene Chr5:146438237-146444132 (+)
AKR/J MGP_AKRJ_G0030286
protein coding gene Chr5:150940231-150946096 (+)
BALB/cJ MGP_BALBcJ_G0030368
protein coding gene Chr5:147650896-147656775 (+)
C3H/HeJ MGP_C3HHeJ_G0030082
protein coding gene Chr5:151904262-151910129 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030823
protein coding gene Chr5:158515202-158521068 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028036
protein coding gene Chr5:140854798-140860614 (+)
CAST/EiJ MGP_CASTEiJ_G0029484
protein coding gene Chr5:151460069-151466010 (+)
CBA/J MGP_CBAJ_G0030060
protein coding gene Chr5:165121436-165127316 (+)
DBA/2J MGP_DBA2J_G0030204
protein coding gene Chr5:146122227-146128096 (+)
FVB/NJ MGP_FVBNJ_G0030158
protein coding gene Chr5:145318403-145324254 (+)
LP/J MGP_LPJ_G0030291
protein coding gene Chr5:153615356-153621247 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030194
protein coding gene Chr5:167403716-167409588 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030853
protein coding gene Chr5:150839700-150847214 (+)
PWK/PhJ MGP_PWKPhJ_G0029198
protein coding gene Chr5:145204606-145210639 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029034
protein coding gene Chr5:148167930-148173838 (+)
WSB/EiJ MGP_WSBEiJ_G0029561
protein coding gene Chr5:151647835-151653704 (+)



Homology
more
  • Human Ortholog
    PDX1, pancreatic and duodenal homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDX1, pancreatic and duodenal homeobox 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1
  • Links
    NCBI Gene ID: 3651
    neXtProt AC: NX_P52945
    UniProt: P52945

  • Chr Location
    13q12.2; chr13:27919982-27926314 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 175
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PDX1
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Pdx1 mouse models; 4 with human PDX1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    69 phenotypes from 9 alleles in 13 genetic backgrounds
    35 phenotypes from multigenic genotypes
    2 images
    96 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal lethality, abnormal pancreatic and liver development, and increased plasma glucose levels. Mice heterozygous for a knock-out allele exhibit abnormal pancreatic development and abnormal glucose homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18609 NCBI Gene Model | MGI Sequence Detail 5019 C57BL/6J ±  kb
    transcript NM_008814 RefSeq | MGI Sequence Detail 2039 C57BL/6  
    polypeptide P52946 UniProt | EBI | MGI Sequence Detail 284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 1
      cDNA 19
      Primer pair 16
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11442, MGD-MRK-23684
    References
    more
    • Summaries
      All 521
      Developmental Gene Expression 357
      Diseases 4
      Gene Ontology 32
      Phenotypes 96
    • Earliest
      J:15273 Ohlsson H, et al., IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J. 1993 Nov;12(11):4251-9
    • Latest
      J:266563 Jorgensen MC, et al., Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice. Development. 2018 Sep 3;145(17)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory