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Pdx1
Gene Detail
Symbol

Name
ID
Pdx1
pancreatic and duodenal homeobox 1
MGI:102851
Synonyms
IDX-1, Ipf1, IPF-1, Mody4, pdx-1, STF-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
86.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr5:147269959-147278008 bp, + strand
From VEGA annotation of GRCm38

  8050 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:175  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PDX1
Gene Tree: Pdx1

Human
homologs
PDX1, pancreatic and duodenal homeobox 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3651
neXtProt AC: NX_P52945

Human Synonyms: GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1

Human Chr (Location): 13q12.1; chr13:27919994-27926314 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human PDX1

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(1) Targeted(15)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit postnatal lethality, abnormal pancreatic and liver development, and increased plasma glucose levels. Mice heterozygous for a knock-out allele exhibit abnormal pancreatic development and abnormal glucose homeostasis.
 
Human Diseases Modeled in Mice Using Pdx1 (3)    Mutations Annotated to Human Diseases (3)   
Interactions
Pdx1 interacts with 238 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process cell differentiation, detection of glucose, ...
Component cytoplasm, intracellular, ...
Function chromatin binding, core promoter sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (305 records)
Data Summary: Results (608)    Tissues (165)    Images (197)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 156
RNA in situ 148
In situ reporter (knock in) 18
Northern blot 9
RT-PCR 277
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PDX1 ; Xenbase pdx1 ; ZFIN pdx1    NEW 
Molecular
reagents
All nucleic(33) Genomic(1) cDNA(18) Primer pair(13) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000037552 (Evidence)
Ensembl Gene Model ENSMUSG00000029644 (Evidence)
Entrez Gene 18609 (Evidence)
UniGene 389714
DFCI TC1588916
DoTS DT.40146522
Consensus CDS Project CCDS39398.1
International Mouse Phenotyping Consortium Status Pdx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037552 VEGA Gene Model | MGI Sequence Detail 8050 C57BL/6J ±  kb
transcript OTTMUST00000096808 VEGA | MGI Sequence Detail 4318 Not Applicable 
polypeptide OTTMUSP00000054127 VEGA | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR017995 Homeobox protein, antennapedia type
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000012523 pancreas/duodenum homeobox protein 1
References
(Earliest) J:15273 Ohlsson H, et al., IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J. 1993 Nov;12(11):4251-9
(Latest) J:220744 Xu EE, et al., SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models. Diabetologia. 2015 May;58(5):1013-23
All references(428)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-11442, MGD-MRK-23684

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory