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Pdx1
Gene Detail
 Symbol
Name
ID
Pdx1
pancreatic and duodenal homeobox 1
MGI:102851
Synonyms IDX-1, Ipf1, IPF-1, Mody4, pdx-1, STF-1
Feature Type protein coding gene
Genetic Map
Chromosome 5
86.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr5:147269959-147278008 bp, + strand
From VEGA annotation of GRCm38

  8050 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:175  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pdx1

Human
homologs
Human Homolog PDX1, pancreatic and duodenal homeobox 1
NCBI Gene ID 3651
neXtProt AC  NX_P52945
Human Synonyms  GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1
Human Chr (Location)  13q12.1; chr13:27920031-27926314 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human PDX1
Alleles
and
phenotypes
All alleles(14) : Targeted(13) Gene trapped(1)
 
Mice homozygous for a knock-out allele exhibit postnatal lethality, abnormal pancreatic and liver development, and increased plasma glucose levels. Mice heterozygous for a knock-out allele exhibit abnormal pancreatic development and abnormal glucose homeostasis.
 
Human Diseases Modeled Using Mouse Pdx1 (3)    Alleles Annotated to Human Diseases(3)   
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process cell differentiation, digestive tract development, ...
Component cell, cytoplasm, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (280 records)
Data Summary: Results (585)    Tissues (160)    Images (179)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 149
RNA in situ 143
In situ reporter (knock in) 10
Northern blot 9
RT-PCR 274
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(31) Genomic(1) cDNA(17) Primer pair(12) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000037552 (Evidence)
Ensembl Gene ModelENSMUSG00000029644 (Evidence)
Entrez Gene18609 (Evidence)
UniGene389714
DFCITC1588916
DoTSDT.40146522
Consensus CDS ProjectCCDS39398.1
International Mouse Knockout Project StatusPdx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037552 VEGA Gene Model | MGI Sequence Detail 8050 C57BL/6J ±  kb
transcript OTTMUST00000096808 VEGA | MGI Sequence Detail 4318 Not Applicable 
polypeptide OTTMUSP00000054127 VEGA | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR017995 Homeobox protein, antennapedia type
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000012523 pancreas/duodenum homeobox protein 1
References (Earliest) J:15273 Ohlsson H, et al., IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J. 1993 Nov;12(11):4251-9
(Latest) J:204870 Liu J, et al., Non-parallel recombination limits Cre-LoxP-based reporters as precise indicators of conditional genetic manipulation. Genesis. 2013 Jun;51(6):436-42
All references(393)
Other
accession IDs
MGD-MRK-11442, MGD-MRK-23684

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory