Automated description from the Alliance of Genome Resources (Release 5.4.0)
Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of insulin secretion and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including digestive system development; negative regulation of apoptotic process; and regulation of DNA-templated transcription. Located in nuclear speck. Is expressed in several structures, including genitourinary system; gut; liver and biliary system; sensory organ; and skeleton. Used to study maturity-onset diabetes of the young; maturity-onset diabetes of the young type 4; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1).