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Lmo2 Gene Detail
Summary
  • Symbol
    Lmo2
  • Name
    LIM domain only 2
  • Synonyms
    Rbtn2, Rbtn-2, Rhom-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102811
    NCBI Gene: 16909
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:103788340-103812223 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 54.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    220 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102811
 protein coding gene Chr2:103788331-103812223 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026208
 protein coding gene Chr2:105978137-106003740 (+)
A/J MGP_AJ_G0026169
 protein coding gene Chr2:101599660-101632439 (+)
AKR/J MGP_AKRJ_G0026150
 protein coding gene Chr2:104341653-104365135 (+)
BALB/cJ MGP_BALBcJ_G0026178
 protein coding gene Chr2:101884876-101909293 (+)
C3H/HeJ MGP_C3HHeJ_G0025929
 protein coding gene Chr2:104688652-104711953 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026629
 protein coding gene Chr2:109512791-109539605 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024020
 protein coding gene Chr2:97262298-97285628 (+)
CAST/EiJ MGP_CASTEiJ_G0025394
 protein coding gene Chr2:105162444-105187496 (+)
CBA/J MGP_CBAJ_G0025907
 protein coding gene Chr2:113227061-113253333 (+)
DBA/2J MGP_DBA2J_G0026044
 protein coding gene Chr2:101151714-101180206 (+)
FVB/NJ MGP_FVBNJ_G0026006
 protein coding gene Chr2:100143738-100170052 (+)
LP/J MGP_LPJ_G0026147
 protein coding gene Chr2:106094320-106119743 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026032
 protein coding gene Chr2:117162838-117186238 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026683
 protein coding gene Chr2:104564426-104589280 (+)
PWK/PhJ MGP_PWKPhJ_G0025129
 protein coding gene Chr2:100665789-100688942 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024930
 protein coding gene Chr2:103776346-103801147 (+)
WSB/EiJ MGP_WSBEiJ_G0025461
 protein coding gene Chr2:105276276-105301196 (+)



Homology
more
  • Human Ortholog
    LMO2, LIM domain only 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LMO2, LIM domain only 2
  • Synonyms
    LMO-2, RBTN2, RBTNL1, RHOM2, TTG2
  • Links
    NCBI Gene ID: 4005
    neXtProt AC: NX_P25791
    UniProt: P25791

  • Chr Location
    11p13; chr11:33858576-33892076 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lmo2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 5 alleles in 4 genetic backgrounds
    31 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit lack of yolk sac erythropoiesis and die around embryonic day 10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1064
  • Tissues
    268
  • cDNA Data
    40
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16909 NCBI Gene Model | MGI Sequence Detail 23884 C57BL/6J ±  kb
    transcript NM_001420381 RefSeq | MGI Sequence Detail 2060 ZRU/MplStud  
    polypeptide P25801 UniProt | EBI | MGI Sequence Detail 158 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 2
      cDNA 40
      Primer pair 5
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13797, MGD-MRK-13800, MGD-MRK-19719
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 43
      Diseases 2
      Gene Ontology 15
      Phenotypes 21
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345473 Lee JG, et al., PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory