Lmo2
Gene Detail

Symbol Name ID

Lmo2 LIM domain only 2 MGI:102811

Synonyms

Rbtn2, Rbtn-2, Rhom-2

Feature Type

protein coding gene

Genetic Map

Chromosome 2

54.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:103957986-103981874 bp, + strand From VEGA annotation of GRCm38   23889 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4072  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Lmo2

Human homologs

Human Homolog		LMO2, LIM domain only 2 (rhombotin-like 1)
NCBI Gene ID		4005
neXtProt AC		NX_P25791
Human Synonyms		RBTN2, RBTNL1, RHOM2, TTG2
Human Chr (Location)		11p13; chr11:33880122-33913836 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygotes for a targeted null mutation exhibit lack of yolk sac erythropoiesis and die around embryonic day 10.5.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	cellular response to thyroid hormone stimulus, embryonic hemopoiesis, ...
Component	nucleus, protein complex, ...
Function	bHLH transcription factor binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (32 records)
Data Summary: Results (292)    Tissues (232)    Images (77)
Theiler Stages: 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	260
Northern blot	18
RT-PCR	14

cDNA source data(38)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(47) Genomic(2) cDNA(38) Primer pair(5) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000014900 (Evidence)
Ensembl Gene Model	ENSMUSG00000032698 (Evidence)
Entrez Gene	16909 (Evidence)
UniGene	29266
DFCI	TC1579580, TC1593394, TC1606903, TC1644477
DoTS	DT.101172939, DT.101174124, DT.110746258, DT.532865, DT.94199863, DT.94199866
NIA Mouse Gene Index	U002187
PDB	1J2O, 2L6Y, 2L6Z, 2LXD
Consensus CDS Project	CCDS16482.2, CCDS50651.1, CCDS50652.1
International Mouse Knockout Project Status	Lmo2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014900	VEGA Gene Model | MGI Sequence Detail	23889	C57BL/6J
transcript	OTTMUST00000035397	VEGA | MGI Sequence Detail	1706	Not Applicable
polypeptide	OTTMUSP00000015819	VEGA | MGI Sequence Detail	228	Not Applicable

All sequences(73) RefSeq(8) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(23 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001781	Zinc finger, LIM-type
Protein Ontology	PR:000009863	rhombotin-2

References

(Earliest) J:15544 Boehm T, et al., The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4367-71
(Latest) J:191738 Harel I, et al., Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18839-44
All references(80)

Other accession IDs

MGD-MRK-13797, MGD-MRK-13800, MGD-MRK-19719