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Lmo2
Gene Detail
Symbol

Name
ID
Lmo2
LIM domain only 2
MGI:102811
Synonyms
Rbtn2, Rbtn-2, Rhom-2
Feature Type
protein coding gene
Genetic Map
Chromosome 2
54.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:103957986-103981874 bp, + strand
From VEGA annotation of GRCm38

  23889 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4072  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LMO2
Gene Tree: Lmo2

Human
homologs
LMO2, LIM domain only 2 (rhombotin-like 1)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4005
neXtProt AC: NX_P25791

Human Synonyms: RBTN2, RBTNL1, RHOM2, TTG2

Human Chr (Location): 11p13; chr11:33858576-33892289 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(5) Transgenic(1)
Incidental mutations (data from CvDC )
 
Homozygotes for a targeted null mutation exhibit lack of yolk sac erythropoiesis and die around embryonic day 10.5.
 
Human Diseases Modeled in Mice Using Lmo2 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Lmo2 interacts with 118 markers (Mir7-1, Mir7b, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cellular response to thyroid hormone stimulus, embryonic hemopoiesis, ...
Component nucleus, protein complex, ...
Function bHLH transcription factor binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (305)    Tissues (241)    Images (82)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 262
Northern blot 29
RT-PCR 14
cDNA source data(38)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA LMO2 ; Xenbase lmo2 ; ZFIN lmo2    NEW 
Molecular
reagents
All nucleic(49) Genomic(2) cDNA(38) Primer pair(5) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000014900 (Evidence)
Ensembl Gene Model ENSMUSG00000032698 (Evidence)
Entrez Gene 16909 (Evidence)
UniGene 29266
DFCI TC1579580, TC1593394, TC1606903, TC1644477
DoTS DT.101172939, DT.101174124, DT.110746258, DT.532865, DT.94199863, DT.94199866
NIA Mouse Gene Index U002187
PDB 1J2O, 2L6Y, 2L6Z, 2LXD
Consensus CDS Project CCDS16482.2, CCDS50651.1, CCDS50652.1
International Mouse Phenotyping Consortium Status Lmo2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014900 VEGA Gene Model | MGI Sequence Detail 23889 C57BL/6J ±  kb
transcript OTTMUST00000035397 VEGA | MGI Sequence Detail 1706 Not Applicable 
polypeptide OTTMUSP00000015819 VEGA | MGI Sequence Detail 228 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(10) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(220 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009863 rhombotin-2
References
(Earliest) J:15544 Boehm T, et al., The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4367-71
(Latest) J:214004 Cleveland SM, et al., LMO2 induces T-cell leukemia with epigenetic deregulation of CD4. Exp Hematol. 2014 Jul;42(7):581-93.e5
All references(85)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13797, MGD-MRK-13800, MGD-MRK-19719

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory