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Lmo2 Gene Detail
Summary
  • Symbol
    Lmo2
  • Name
    LIM domain only 2
  • Synonyms
    Rbtn2, Rbtn-2, Rhom-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102811
    NCBI Gene: 16909
  • Gene Overview
    MyGene.info: LMO2
Location & Maps
more
  • Sequence Map
    Chr2:103957986-103981874 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23889 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LMO2, LIM domain only 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LMO2, LIM domain only 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RBTN2, RBTNL1, RHOM2, TTG2
  • Links
    NCBI Gene ID: 4005
    neXtProt AC: NX_P25791

  • Chr Location
    11p13; chr11:33858576-33892289 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4072
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LMO2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lmo2 mouse models

Human Disease Mouse Models
       Leukemia, Acute Lymphoblastic; ALL   OMIM: 613065 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 5 alleles in 4 genetic backgrounds
    31 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Lmo2
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit lack of yolk sac erythropoiesis and die around embryonic day 10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014900 VEGA Gene Model | MGI Sequence Detail 23889 C57BL/6J ±  kb
transcript OTTMUST00000035397 VEGA | MGI Sequence Detail 1706 Not Applicable  
polypeptide OTTMUSP00000015819 VEGA | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    220 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    Genomic 2
    cDNA 38
    Primer pair 5
    Other 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13797, MGD-MRK-13800, MGD-MRK-19719
References
more
  • Summaries
    All 83
    Developmental Gene Expression 36
    Diseases 2
    Gene Ontology 12
    Phenotypes 18
  • Earliest
    J:15544 Boehm T, et al., The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4367-71
  • Latest
    J:214004 Cleveland SM, et al., LMO2 induces T-cell leukemia with epigenetic deregulation of CD4. Exp Hematol. 2014 Jul;42(7):581-93.e5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory