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Acvr2a
Gene Detail
 Symbol
Name
ID
Acvr2a
activin receptor IIA
MGI:102806
Synonyms ActRIIa, Acvr2, tActRII
Feature Type protein coding gene
Genetic Map
Chromosome 2
28.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:48814109-48903269 bp, + strand
From VEGA annotation of GRCm38

  89161 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20391  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: type II serine/threonine-protein kinase receptor, Activin/BMP types
Gene Tree: Acvr2a

Human
homologs
Human Homolog ACVR2A, activin A receptor, type IIA
NCBI Gene ID 92
neXtProt AC  NX_P27037
Human Synonyms  ACTRII, ACVR2
Human Chr (Location)  2q22.3; chr2:147844517-147930827 (+)  GRCh38
Alleles
and
phenotypes
All alleles(17) : Gene trapped(11) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
While most mice homozygous for targeted mutations that inactivate this gene appear normal, a few display skeletal and facial abnormalities. As adults, follicle-stimulating hormone is suppressed, affecting reproduction.
 
Human Diseases Modeled Using Mouse Acvr2a (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process activin receptor signaling pathway, anterior/posterior pattern specification, ...
Component cell surface, cytoplasm, ...
Function activin-activated receptor activity, activin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (160)    Tissues (122)    Images (25)
Theiler Stages: 4, 7, 8, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 123
Northern blot 13
RT-PCR 24
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(34) Genomic(7) cDNA(18) Primer pair(7) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000012394 (Evidence)
Ensembl Gene ModelENSMUSG00000052155 (Evidence)
Entrez Gene11480 (Evidence)
NIA Mouse Gene IndexU001727
EC2.7.11.30
PDB1BTE, 2GOO, 1LX5
Consensus CDS ProjectCCDS16021.1
International Mouse Knockout Project StatusAcvr2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012394 VEGA Gene Model | MGI Sequence Detail 89161 C57BL/6J ±  kb
transcript OTTMUST00000029496 VEGA | MGI Sequence Detail 5686 Not Applicable 
polypeptide OTTMUSP00000013280 VEGA | MGI Sequence Detail 513 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(196 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000333 Activin type II/Transforming growth factor-beta II receptor
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR000472 TGF-beta receptor/activin receptor, type I/II
Protein Ontology PR:000000070 activin receptor type-2A
References (Earliest) J:11226 Mathews LS, et al., Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell. 1991 Jun 14;65(6):973-82
(Latest) J:208630 Wang H, et al., Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5735-40
All references(96)
Other
accession IDs
MGD-MRK-19714

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory