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Fstl1
Gene Detail
 Symbol
Name
ID
Fstl1
follistatin-like 1
MGI:102793
Synonyms TSC-36
Feature Type protein coding gene
Genetic Map
Chromosome 16
26.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:37776873-37836514 bp, + strand
From VEGA annotation of GRCm38

  59642 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5144  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Fstl1

Human
homologs
Human Homolog FSTL1, follistatin-like 1
NCBI Gene ID 11167
neXtProt AC  NX_Q12841
Human Synonyms  FRP, FSL1, MIR198
Human Chr (Location)  3q13.33; chr3:120394214-120451071 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(34) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality, soft and enlarged trachea, cyanosis, primary atelectasis, lung epithelial cell hyperplasia, over-expanded bronchiole, impaired pneumocyte differentiation and maturation, and decreased surfactant production.
 
Interactions
Fstl1 interacts with 269 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process response to starvation
Component extracellular region, extracellular space, ...
Function calcium ion binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (357)    Tissues (118)    Images (147)
Theiler Stages: 11, 13, 15, 17, 20, 21, 22, 23, 24, 27, 28
Assay TypeResults
RNA in situ 348
Northern blot 2
RT-PCR 7
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(15) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000025717 (Evidence)
Ensembl Gene ModelENSMUSG00000022816 (Evidence)
Entrez Gene14314 (Evidence)
DoTSDT.537027, DT.537028, DT.87068948, DT.97375666
NIA Mouse Gene IndexU017087
Consensus CDS ProjectCCDS37339.1
International Mouse Knockout Project StatusFstl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025717 VEGA Gene Model | MGI Sequence Detail 59642 C57BL/6J ±  kb
transcript OTTMUST00000063330 VEGA | MGI Sequence Detail 3789 Not Applicable 
polypeptide OTTMUSP00000031299 VEGA | MGI Sequence Detail 306 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(314 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR003645 Follistatin-like, N-terminal
InterPro IPR015369 Follistatin/Osteonectin EGF domain
InterPro IPR002350 Kazal domain
Protein Ontology PR:000007685 follistatin-related protein 1
References (Earliest) J:15692 Shibanuma M, et al., Cloning from a mouse osteoblastic cell line of a set of transforming-growth-factor-beta 1-regulated genes, one of which seems to encode a follistatin-related polypeptide. Eur J Biochem. 1993 Oct 1;217(1):13-9
(Latest) J:209770 Geng Y, et al., Impaired elastin deposition in Fstl1-/- lung allograft under the renal capsule. PLoS One. 2013;8(11):e81368
All references(64)
Other
accession IDs
MGD-MRK-19701, MGI:2146409, MGI:2146619

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory