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Fstl1
Gene Detail
Symbol

Name
ID
Fstl1
follistatin-like 1
MGI:102793
Synonyms
TSC-36
Feature Type
protein coding gene
Genetic Map
Chromosome 16
26.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:37776873-37836514 bp, + strand
From VEGA annotation of GRCm38

  59642 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5144  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: FSTL1
Gene Tree: Fstl1

Human
homologs
FSTL1, follistatin-like 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 11167
neXtProt AC: NX_Q12841

Human Synonyms: FRP, FSL1, MIR198

Human Chr (Location): 3q13.33; chr3:120394214-120451071 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Gene trapped(34) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality, soft and enlarged trachea, cyanosis, primary atelectasis, lung epithelial cell hyperplasia, over-expanded bronchiole, impaired pneumocyte differentiation and maturation, and decreased surfactant production.
 
Interactions
Fstl1 interacts with 268 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process response to starvation
Component extracellular exosome, extracellular region, ...
Function calcium ion binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (357)    Tissues (118)    Images (147)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 348
Northern blot 2
RT-PCR 7
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fstl1 ; ZFIN fstl1a, fstl1b    NEW 
Molecular
reagents
All nucleic(21) cDNA(16) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000025717 (Evidence)
Ensembl Gene Model ENSMUSG00000022816 (Evidence)
Entrez Gene 14314 (Evidence)
DoTS DT.537027, DT.537028, DT.87068948, DT.97375666
NIA Mouse Gene Index U017087
Consensus CDS Project CCDS37339.1
International Mouse Phenotyping Consortium Status Fstl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025717 VEGA Gene Model | MGI Sequence Detail 59642 C57BL/6J ±  kb
transcript OTTMUST00000063330 VEGA | MGI Sequence Detail 3789 Not Applicable 
polypeptide OTTMUSP00000031299 VEGA | MGI Sequence Detail 306 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(314 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand domain pair
InterPro IPR003645 Follistatin-like, N-terminal
InterPro IPR015369 Follistatin/Osteonectin EGF domain
InterPro IPR002350 Kazal domain
Protein Ontology PR:000007685 follistatin-related protein 1
References
(Earliest) J:15692 Shibanuma M, et al., Cloning from a mouse osteoblastic cell line of a set of transforming-growth-factor-beta 1-regulated genes, one of which seems to encode a follistatin-related polypeptide. Eur J Biochem. 1993 Oct 1;217(1):13-9
(Latest) J:209770 Geng Y, et al., Impaired elastin deposition in Fstl1-/- lung allograft under the renal capsule. PLoS One. 2013;8(11):e81368
All references(63)
Other
accession IDs
MGD-MRK-19701, MGI:2146409, MGI:2146619

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory