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Six3 Gene Detail
Summary
  • Symbol
    Six3
  • Name
    sine oculis-related homeobox 3
  • Synonyms
    E130112M24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:102764
    NCBI Gene: 20473
  • Gene Overview
    MyGene.info: SIX3
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:85613608-85626191 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 55.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102764
protein coding gene Chr17:85613608-85629302 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024088
protein coding gene Chr17:88866938-88882570 (+)
A/J MGP_AJ_G0024047
protein coding gene Chr17:86021842-86039819 (+)
AKR/J MGP_AKRJ_G0024016
protein coding gene Chr17:87423590-87439214 (+)
BALB/cJ MGP_BALBcJ_G0024048
protein coding gene Chr17:85865204-85880825 (+)
C3H/HeJ MGP_C3HHeJ_G0023813
protein coding gene Chr17:88301848-88317485 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024493
protein coding gene Chr17:91992077-92008576 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021932
protein coding gene Chr17:81215581-81231303 (+)
CAST/EiJ MGP_CASTEiJ_G0023292
protein coding gene Chr17:89108864-89124411 (+)
CBA/J MGP_CBAJ_G0023787
protein coding gene Chr17:95798090-95816249 (+)
DBA/2J MGP_DBA2J_G0023915
protein coding gene Chr17:84485545-84501180 (+)
FVB/NJ MGP_FVBNJ_G0023881
protein coding gene Chr17:83979300-83994973 (+)
LP/J MGP_LPJ_G0023999
protein coding gene Chr17:89624658-89643687 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023909
protein coding gene Chr17:95808908-95824557 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024538
protein coding gene Chr17:87935526-87951185 (+)
PWK/PhJ MGP_PWKPhJ_G0023037
protein coding gene Chr17:84083179-84099286 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022848
protein coding gene Chr17:84737470-84753120 (+)
WSB/EiJ MGP_WSBEiJ_G0023358
protein coding gene Chr17:88792553-88810485 (+)



Homology
more
  • Human Ortholog
    SIX3, SIX homeobox 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SIX3, SIX homeobox 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HPE2
  • Links
    NCBI Gene ID: 6496
    neXtProt AC: NX_O95343
    UniProt: O95343

  • Chr Location
    2p21; chr2:44941898-44946077 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3947
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SIX3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Six3 mouse models; 1 with human SIX3 associations

Human Disease Mouse Models
      
IDs
View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 5 alleles in 4 genetic backgrounds
    12 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene die at birth with anterior structures of the head and brain undeveloped.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20473 NCBI Gene Model | MGI Sequence Detail 12584 C57BL/6J ±  kb
    transcript NM_011381 RefSeq | MGI Sequence Detail 3680 C57BL/6  
    polypeptide Q62233 UniProt | EBI | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR001356 Homeobox domain
      IPR009057 Homeobox-like domain superfamily
      IPR031701 Homeobox protein SIX1, N-terminal SD domain
      IPR032949 Homeobox protein SIX3
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 18
      Primer pair 5
      Other 21

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-19669, MGI:1925249
    References
    more
    • Summaries
      All 272
      Developmental Gene Expression 232
      Diseases 2
      Gene Ontology 24
      Phenotypes 15
    • Earliest
      J:23775 Oliver G, et al., Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
    • Latest
      J:264647 O'Brien LL, et al., Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies. PLoS Genet. 2018 Jan;14(1):e1007181

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory