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Six3
Gene Detail
Symbol

Name
ID
Six3
sine oculis-related homeobox 3
MGI:102764
Synonyms
E130112M24Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 17
55.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:85613608-85630791 bp, + strand
From VEGA annotation of GRCm38

  17184 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3947  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SIX3
Gene Tree: Six3

Human
homologs
SIX3, SIX homeobox 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6496
neXtProt AC: NX_O95343

Human Synonyms: HPE2

Human Chr (Location): 2p21; chr2:44941729-44966751 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SIX3

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene die at birth with anterior structures of the head and brain undeveloped.
 
Human Diseases Modeled in Mice Using Six3 (1)    Mutations Annotated to Human Diseases (4)   
Interactions
Six3 interacts with 373 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process apoptotic process involved in development, brain development, ...
Component nucleus
Function DNA binding, histone deacetylase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (204 records)
Data Summary: Results (653)    Tissues (324)    Images (190)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 599
Northern blot 1
RT-PCR 53
cDNA source data(14)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase six3 ; ZFIN six3a, six3b    NEW 
Molecular
reagents
All nucleic(34) cDNA(17) Primer pair(4) Other(13)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000040062 (Evidence)
Ensembl Gene Model ENSMUSG00000038805 (Evidence)
Entrez Gene 20473 (Evidence)
DFCI TC1594026, TC1586540, TC1631540, TC1596892, TC1696733
DoTS DT.110561278, DT.60104366, DT.55188618
NIA Mouse Gene Index U018302
Consensus CDS Project CCDS50203.1
International Mouse Phenotyping Consortium Status Six3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040062 VEGA Gene Model | MGI Sequence Detail 17184 C57BL/6J ±  kb
transcript OTTMUST00000083049 VEGA | MGI Sequence Detail 2838 Not Applicable 
polypeptide OTTMUSP00000044571 VEGA | MGI Sequence Detail 347 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000014898 homeobox protein SIX3
References
(Earliest) J:23775 Oliver G, et al., Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
(Latest) J:218837 Song H, et al., Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation. Dev Biol. 2015 Feb 15;398(2):280-91
All references(241)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-19669, MGI:1925249

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory