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Six3
Gene Detail
Symbol

Name
ID
Six3
sine oculis-related homeobox 3
MGI:102764
Synonyms
E130112M24Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 17
55.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:85613608-85629302 bp, + strand
From VEGA annotation of GRCm38

  15695 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3947  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Human
homologs
Human Homolog SIX3, SIX homeobox 3
NCBI Gene ID 6496
neXtProt AC  NX_O95343
Human Synonyms  HPE2
Human Chr (Location)  2p21; chr2:44941898-44946077 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human SIX3
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene die at birth with anterior structures of the head and brain undeveloped.
 
Human Diseases Modeled Using Mouse Six3 (1)    Alleles Annotated to Human Diseases(4)   
Interactions
Six3 interacts with 374 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process apoptotic process involved in development, brain development, ...
Component nucleus
Function DNA binding, histone deacetylase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (199 records)
Data Summary: Results (653)    Tissues (324)    Images (190)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 599
Northern blot 1
RT-PCR 53
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(17) Primer pair(4) Other(13)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000040062 (Evidence)
Ensembl Gene ModelENSMUSG00000098933 (Evidence), ENSMUSG00000038805 (Evidence)
Entrez Gene20473 (Evidence)
DFCITC1596892, TC1594026, TC1586540, TC1631540, TC1696733
DoTSDT.55188618, DT.110561278, DT.60104366
NIA Mouse Gene IndexU018302
Consensus CDS ProjectCCDS50203.1
International Mouse Knockout Project StatusSix3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040062 VEGA Gene Model | MGI Sequence Detail 15695 C57BL/6J ±  kb
transcript OTTMUST00000083049 VEGA | MGI Sequence Detail 2838 Not Applicable 
polypeptide OTTMUSP00000044571 VEGA | MGI Sequence Detail 347 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000014898 homeobox protein SIX3
References
(Earliest) J:23775 Oliver G, et al., Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
(Latest) J:213512 Werber M, et al., The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development. 2014 Jun;141(11):2325-30
All references(237)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-19669, MGI:1925249

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory