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Six3
Gene Detail
 Symbol
Name
ID
Six3
sine oculis-related homeobox 3
MGI:102764
BioType Conflict
Synonyms E130112M24Rik
Feature Type protein coding gene
Genetic Map
Chromosome 17
55.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:85620834-85626191 bp, + strand
From NCBI annotation of GRCm38

  5358 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3947  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Human
homologs
Human Homolog SIX3, SIX homeobox 3
NCBI Gene ID 6496
neXtProt AC  NX_O95343
Human Synonyms  HPE2
Human Chr (Location)  2p21; chr2:44941898-44946077 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human SIX3
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene die at birth with anterior structures of the head and brain undeveloped.
 
Human Diseases Modeled Using Mouse Six3 (1)    Alleles Annotated to Human Diseases(4)   
Interactions
Six3 interacts with 374 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process brain development, camera-type eye development, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (192 records)
Data Summary: Results (653)    Tissues (302)    Images (188)
Theiler Stages: 9, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 599
Northern blot 1
RT-PCR 53
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(17) Primer pair(4) Other(13)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000040062 (Evidence), OTTMUSG00000044493 (Evidence)
Ensembl Gene ModelENSMUSG00000038805 (Evidence), ENSMUSG00000098933 (Evidence)
Entrez Gene20473 (Evidence)
DFCITC1586540, TC1594026, TC1596892, TC1631540, TC1696733
DoTSDT.110561278, DT.55188618, DT.60104366
NIA Mouse Gene IndexU018302
Consensus CDS ProjectCCDS50203.1
International Mouse Knockout Project StatusSix3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20473 NCBI Gene Model | MGI Sequence Detail 5358 C57BL/6J ±  kb
transcript NM_011381 RefSeq | MGI Sequence Detail 3680 C57BL/6 
polypeptide Q62233 UniProt | EBI | MGI Sequence Detail 333 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000014898 homeobox protein SIX3
Graphical View of Protein Domain Structure
References (Earliest) J:23775 Oliver G, et al., Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
(Latest) J:208421 Klimova L, et al., Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development. 2014 Mar;141(6):1292-302
All references(224)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-19669, MGI:1925249

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory