Six3
Gene Detail

Symbol Name ID

Six3 sine oculis-related homeobox 3 MGI:102764

Synonyms

E130112M24Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 17

55.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:85613608-85631813 bp, + strand From VEGA annotation of GRCm38   18206 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3947  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Six3

Human homologs

Human Homolog		SIX3, SIX homeobox 3
NCBI Gene ID		6496
neXtProt AC		NX_O95343
Human Synonyms		HPE2
Human Chr (Location)		2p21; chr2:45169037-45173216 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SIX3

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for disruptions of this gene die at birth with anterior structures of the head and brain undeveloped.

 
Human Diseases Modeled Using Mouse Six3 (1)    Alleles Annotated to Human Diseases(4)   

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	brain development, camera-type eye development, ...
Component	nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (181 records)
Data Summary: Results (522)    Tissues (263)    Images (142)
Theiler Stages: 9, 11, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	493
Northern blot	1
RT-PCR	28

cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(28) cDNA(17) Primer pair(2) Other(9)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000040062 (Evidence)
Ensembl Gene Model	ENSMUSG00000038805 (Evidence)
Entrez Gene	20473 (Evidence)
DFCI	TC1586540, TC1594026, TC1596892, TC1631540, TC1696733
DoTS	DT.110561278, DT.55188618, DT.60104366
NIA Mouse Gene Index	U018302
Consensus CDS Project	CCDS50203.1
International Mouse Knockout Project Status	Six3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000040062	VEGA Gene Model | MGI Sequence Detail	18206	C57BL/6J
transcript	OTTMUST00000104035	VEGA | MGI Sequence Detail	1337	Not Applicable
polypeptide	OTTMUSP00000058171	VEGA | MGI Sequence Detail	354	Not Applicable

All sequences(41) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(4 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000014898	homeobox protein SIX3

References

(Earliest) J:23775 Oliver G, et al., Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
(Latest) J:195145 Amaniti EM, et al., Gli3 is required in Emx1(+) progenitors for the development of the corpus callosum. Dev Biol. 2013 Apr 15;376(2):113-24
All references(212)

Other accession IDs

MGD-MRK-19669, MGI:1925249