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Symbol Name ID |
Six3
sine oculis-related homeobox 3 MGI:102764 |
| Darker colors indicate more annotations |
| Human Phenotypes | Iris coloboma |
Chorioretinal coloboma |
Optic atrophy |
Retinopathy |
Remnants of the hyaloid vascular system |
Cyclopia |
Deeply set eye |
Hypertelorism |
Hypotelorism |
Proptosis |
Anophthalmia |
Microphthalmia |
Ptosis |
| Disease(s) Associated with SIX3 | |||||||||||||
| holoprosencephaly | |||||||||||||
| holoprosencephaly 2 |
| Mouse Phenotypes | abnormal lens morphology |
abnormal lens development |
abnormal lens induction |
abnormal lens vesicle development |
abnormal lens fiber morphology |
aphakia |
cataract |
small lens |
abnormal optic vesicle formation |
absent optic vesicle |
anophthalmia |
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| Availability | Mouse Genotype | |||||||||||
| Six3tm1Gco/Six3tm1Gco | ||||||||||||
| Six3tm2Gco/Six3tm2.1Gco Tg(Pax6-cre,GFP)1Pgr/0 (conditional) |
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| Six3tm2Gco/Six3tm2.1Gco Tg(CAG-cre/Esr1*)5Amc/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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