Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and transcription corepressor binding activity. Involved in several processes, including camera-type eye development; forebrain development; and lens fiber cell apoptotic process. Acts upstream of or within several processes, including forebrain development; lens induction in camera-type eye; and protein import into nucleus. Located in nucleus. Is expressed in several structures, including alimentary system; embryo ectoderm; limb; nervous system; and sensory organ. Used to study holoprosencephaly 2. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 2. Orthologous to human SIX3 (SIX homeobox 3).